LOCUS       XP_042799231             441 aa            linear   MAM 11-AUG-2021
DEFINITION  suppressor of cytokine signaling 4 [Panthera leo].
ACCESSION   XP_042799231
VERSION     XP_042799231.1
DBLINK      BioProject: PRJNA751610
DBSOURCE    REFSEQ: accession XM_042943297.1
KEYWORDS    RefSeq.
SOURCE      Panthera leo (lion)
  ORGANISM  Panthera leo
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
            Pantherinae; Panthera.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_056684.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Panthera leo Annotation Release 100
            Annotation Version          :: 100
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 9.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Panthera leo"
                     /isolate="Ple1"
                     /db_xref="taxon:9689"
                     /chromosome="B3"
                     /sex="male"
                     /cell_type="Fibroblast"
                     /tissue_type="Fibroblasts"
                     /dev_stage="adult"
     Protein         1..441
                     /product="suppressor of cytokine signaling 4"
                     /calculated_mol_wt=50311
     Region          58..109
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          276..376
                     /region_name="SH2_SOCS4"
                     /note="Src homology 2 (SH2) domain found in suppressor of
                     cytokine signaling (SOCS) proteins; cd10385"
                     /db_xref="CDD:198248"
     Site            order(284,286)
                     /site_type="other"
                     /note="Elongin-C binding interface [polypeptide binding]"
                     /db_xref="CDD:198248"
     Site            order(294,312,314,322,335)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198248"
     Site            order(345,347,365)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198248"
     Region          385..440
                     /region_name="SOCS_SOCS4"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS4-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. The general
                     function of the SOCS box is the...; cd03738"
                     /db_xref="CDD:239707"
     Site            order(386..391,397,404,410,415)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239707"
     CDS             1..441
                     /gene="SOCS4"
                     /coded_by="XM_042943297.1:633..1958"
                     /db_xref="GeneID:122222731"
ORIGIN      
        1 maessennsk nvdvrpktsr srsadrkdgy vwsgkklsws kksescsdae tvnaiektev
       61 plrsqerkhs cssieldldh scghrflgrs lkqklqdavg qcfpikncsg rhssglpskr
      121 kihiselmld kcpfpprsdl afrwhfikrh tapinpksse wvstdlaqse lrdgqlkqrr
      181 nveeevncfs htdvqpcvit tnnascrggp vtgsvmnlvs nnsiedsdmd sddeiitlct
      241 ssrkrnkpkw emdeeilqle tppkyhtqid yvhclvpdll qinnnpcywg vmdkyaaeal
      301 legkpegtfl lrdsaqedyl fsvsfrrysr slharieqwn hnfsfdahdp cvfhspditg
      361 llehykdpsa cmffepllst plirtfpfsl qhicrtvicn cttydgidal pipssmklyl
      421 keyhykskvr vlridapeqq c
//