LOCUS       XP_054677803             536 aa            linear   VRT 02-APR-2023
DEFINITION  suppressor of cytokine signaling 5 [Grus americana].
ACCESSION   XP_054677803
VERSION     XP_054677803.1
DBLINK      BioProject: PRJNA950963
DBSOURCE    REFSEQ: accession XM_054821828.1
KEYWORDS    RefSeq.
SOURCE      Grus americana (Whooping crane)
  ORGANISM  Grus americana
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Neoaves; Gruiformes; Gruidae;
            Grus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_072854) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_028858705.1-RS_2023_03
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 03/31/2023
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Grus americana"
                     /isolate="bGruAme1"
                     /db_xref="taxon:9117"
                     /chromosome="3"
                     /sex="male"
                     /tissue_type="blood"
                     /dev_stage="adult"
                     /geo_loc_name="USA: Baraboo, Wisconsin"
                     /lat_lon="43.5477 N 89.7563 W"
                     /collection_date="2019-12-03"
                     /collected_by="Barry Kinney Hartup"
     Protein         1..536
                     /product="suppressor of cytokine signaling 5"
                     /calculated_mol_wt=61248
     Region          145..195
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          370..470
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(388,406,427,429)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198173"
     Site            order(428,458)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198173"
     Region          479..535
                     /region_name="SOCS_SOCS5"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS5-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. SOCS5
                     inhibits Th2 differentiation by inhibiting...; cd03739"
                     /db_xref="CDD:239708"
     Site            order(480..485,491,498,504,509)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239708"
     CDS             1..536
                     /gene="SOCS5"
                     /coded_by="XM_054821828.1:126..1736"
                     /db_xref="GeneID:129204969"
ORIGIN      
        1 mdkvgkmwnn fkyrcqnlfs heggsqnenv vvtssscssa kekaiqitdl aqqqpnsplr
       61 enialqlgls psknparrnq ncvteipqiv eisiekends cvttgarlar rdsysrhapw
      121 ggkkkhscst ktqssldtek rfgrtrsglq rrerrygvss vhdmdavsnr tvgsrslrqr
      181 lqdtvglcfp mrtyskqskp lfsnkrkihl selmlekcpf pagsdlaqkw hlikqhtapv
      241 sphstffdtf dpslvstede edrlrerrrl sieegvdppp naqihtfeat aqvnplyklg
      301 pklapgmtel tgdknitppg ncdseedttt lclqsrrqkq rqmsgeshgh isrqgawkvh
      361 tqidyihclv pdllqitgnp cywgvmdrye aeallegkpe gtfllrdsaq edylfsvsfr
      421 rynrslhari eqwnhnfsfd ahdpcvfhss tvtgllehyk dpsscmffep lltvslnrtf
      481 pfslqyicra vicrcttydg iddlplpsml qdflkeyhyk qkvrvrwler epiktk
//