LOCUS       XP_054826130             432 aa            linear   VRT 05-APR-2023
DEFINITION  suppressor of cytokine signaling 4 [Eublepharis macularius].
ACCESSION   XP_054826130
VERSION     XP_054826130.1
DBLINK      BioProject: PRJNA949696
DBSOURCE    REFSEQ: accession XM_054970155.1
KEYWORDS    RefSeq.
SOURCE      Eublepharis macularius
  ORGANISM  Eublepharis macularius
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Lepidosauria; Squamata; Bifurcata; Gekkota; Eublepharidae;
            Eublepharinae; Eublepharis.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_072791) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_028583425.1-RS_2023_03
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 03/30/2023
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Eublepharis macularius"
                     /isolate="TG4126"
                     /isolation_source="laboratory cross"
                     /db_xref="taxon:481883"
                     /chromosome="2"
                     /tissue_type="blood"
                     /dev_stage="juvenile"
                     /collection_date="2020"
                     /collected_by="Tony Gamble"
     Protein         1..432
                     /product="suppressor of cytokine signaling 4"
                     /calculated_mol_wt=49167
     Region          61..111
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          267..367
                     /region_name="SH2_SOCS4"
                     /note="Src homology 2 (SH2) domain found in suppressor of
                     cytokine signaling (SOCS) proteins; cd10385"
                     /db_xref="CDD:198248"
     Site            order(275,277)
                     /site_type="other"
                     /note="Elongin-C binding interface [polypeptide binding]"
                     /db_xref="CDD:198248"
     Site            order(285,303,305,313,326)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198248"
     Site            order(336,338,356)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198248"
     Region          376..431
                     /region_name="SOCS"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; cl02533"
                     /db_xref="CDD:470605"
     Site            order(377..382,388,395,401)
                     /site_type="active"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     CDS             1..432
                     /gene="SOCS4"
                     /coded_by="XM_054970155.1:1439..2737"
                     /db_xref="GeneID:129323632"
ORIGIN      
        1 maenkerdnk ntdvrpktsr srsadrkdgy vwsrkklsws krsdsssdae tastsgkstf
       61 glrnqerkhs cssteldler scghrflgrs lkqklqdavg qcfpikncss rhssalpskr
      121 kihiselmld tcpfpprsel afrwhlikrh tapiqqkses wlsveschse gkdgdvesad
      181 gggpvvlqac dfssgascrc sprdesaasr pmknreesdm dsddevvtlc tssrkrnkpr
      241 wdpddellql esppkyhtqi dyvhclvpdl lqinnnpcyw gvmdkyaaea lldgkpegtf
      301 llrdsaqedy lfsvsfrrys rslharieqw nhnfsfdahd pcvfhspdit gllehykdps
      361 scmffeplls tplnrtfpfs lqhicrtvic nyttydgida lpvppsvkly lkeyhykskv
      421 rvlridapeq qt
//