LOCUS       XP_074234903             536 aa            linear   MAM 06-JUN-2025
DEFINITION  suppressor of cytokine signaling 5 [Camelus bactrianus].
ACCESSION   XP_074234903
VERSION     XP_074234903.1
DBLINK      BioProject: PRJNA1263396
DBSOURCE    REFSEQ: accession XM_074378802.1
KEYWORDS    RefSeq.
SOURCE      Camelus bactrianus (Bactrian camel)
  ORGANISM  Camelus bactrianus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Tylopoda;
            Camelidae; Camelus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_133553) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_048773025.1-RS_2025_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/04/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Camelus bactrianus"
                     /isolate="YW-2024"
                     /db_xref="taxon:9837"
                     /chromosome="15"
                     /sex="female"
                     /tissue_type="blood"
                     /dev_stage="adult"
                     /geo_loc_name="China: Inner Mongolia"
                     /collection_date="2022-06-30"
                     /breed="Bactrian camel"
     Protein         1..536
                     /product="suppressor of cytokine signaling 5"
                     /calculated_mol_wt=61169
     Region          145..193
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          370..470
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(388,406,427,429)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198248"
     Site            order(428,458)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198248"
     Region          479..534
                     /region_name="SOCS_SOCS5"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS5-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. SOCS5
                     inhibits Th2 differentiation by inhibiting...; cd03739"
                     /db_xref="CDD:239708"
     Site            order(480..485,491,498,504,509)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239708"
     CDS             1..536
                     /gene="SOCS5"
                     /coded_by="XM_074378802.1:259..1869"
                     /db_xref="GeneID:105079027"
ORIGIN      
        1 mdkvgkmwnn fkyrcqnlfs heggsrsenm dmntnrclsv keknisvgds apqqqssplr
       61 envalqlgls paknssrrnq ncateipqiv eisiekdnds citpgarlar rdsysrhapw
      121 ggkkkhscst ktqssldtdk kfgrtrsglq rrerrygvss vhdmdsissr tvgsrslrqr
      181 lqdtvglcfp mrtynkqskp lfsnkrkihl selmlekcpf pagsdlaqkw hlikqhtapv
      241 sphstffdtf dpslvstede edrlrerrrl sieegvdppp naqihtfeat aqvnplyklg
      301 pklapgmtei ngdssaipqa ncdseedttt lclqsrrqkq rqvsgdshah isrqgawkvh
      361 tqidyihclv pdllqitgnp cywgvmdrye aeallegkpe gtfllrdsaq edylfsvsfr
      421 rynrslhari eqwnhnfsfd ahdpcvfhss tvtgllehyk dpsscmffep lltislnrtf
      481 pfslqyicra vicrcttydg idglplpsml qdflkeyhyk qkvrvrwler epvkak
//