KEGG   PATHWAY: sac04122
Entry
sac04122                    Pathway                                

Name
Sulfur relay system - Staphylococcus aureus subsp. aureus COL (MRSA)
Description
Ubiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein modification evolved from prokaryotic sulfurtransfer systems. Molybdenum cofactor (Moco) and thiamin are sulfur-containing cofactors whose biosynthesis includes a key sulfur transfer step that uses unique sulfur carrier proteins, MoaD and ThiS. Ubiquitin, MoaD, and ThiS are all structurally related proteins whose C-termini are activated through adenylation by homologous E1-like enzymes. s2T biosynthesis may share similar chemistry with Moco and thiamin synthesis. In Saccharomyces cerevisiae, Urm1 and Uba4 function as part of a ubl protein conjugation system, though they have sequence homology to bacterial sulfur-transfer enzymes and the ability to function in sulfur transfer.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
sac04122  Sulfur relay system
sac04122

Organism
Staphylococcus aureus subsp. aureus COL (MRSA) [GN:sac]
Gene
SACOL1677  aminotransferase, class V [KO:K04487] [EC:2.8.1.7]
SACOL1765  aminotransferase, class V [KO:K04487] [EC:2.8.1.7]
SACOL1676  trmU; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase [KO:K00566] [EC:2.8.1.13]
SACOL2264  moaE; molybdenum cofactor biosynthesis protein E [KO:K03635] [EC:2.8.1.12]
SACOL2261  moaA; molybdenum cofactor biosynthesis protein A [KO:K03639] [EC:4.1.99.22]
SACOL2263  moaD; molybdopterin converting factor, subunit 1 [KO:K03636]
SACOL2269  molybdopterin biosynthesis MoeB protein, putative [KO:K21029] [EC:2.7.7.80]
SACOL2267  moaC; molybdenum cofactor biosynthesis protein C [KO:K03637] [EC:4.6.1.17]
SACOL2268  moaB; molybdenum cofactor biosynthesis protein B [KO:K03638] [EC:2.7.7.75]
SACOL1764  thiI; thiamine biosynthesis protein ThiI [KO:K03151] [EC:2.8.1.4]
Compound
C00019  S-Adenosyl-L-methionine
C00041  L-Alanine
C00044  GTP
C00097  L-Cysteine
C00378  Thiamine
C00868  tRNA uridine
C00979  O-Acetyl-L-serine
C05924  Molybdopterin
C17322  tRNA containing 2-thiouridine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
Reference
  Authors
Noma A, Sakaguchi Y, Suzuki T
  Title
Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions.
  Journal
Nucleic Acids Res 37:1335-52 (2009)
DOI:10.1093/nar/gkn1023
Reference
  Authors
Iyer LM, Burroughs AM, Aravind L
  Title
The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains.
  Journal
Genome Biol 7:R60 (2006)
DOI:10.1186/gb-2006-7-7-r60
Reference
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Related
pathway
sac00270  Cysteine and methionine metabolism
sac00730  Thiamine metabolism
sac00790  Folate biosynthesis
KO pathway
ko04122   

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