KEGG   Saimiri boliviensis boliviensis (Bolivian squirrel monkey): 101027982
Entry
101027982         CDS       T04350                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
sbq  Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Pathway
sbq00562  Inositol phosphate metabolism
sbq01100  Metabolic pathways
sbq01521  EGFR tyrosine kinase inhibitor resistance
sbq01522  Endocrine resistance
sbq01524  Platinum drug resistance
sbq04012  ErbB signaling pathway
sbq04014  Ras signaling pathway
sbq04015  Rap1 signaling pathway
sbq04024  cAMP signaling pathway
sbq04062  Chemokine signaling pathway
sbq04066  HIF-1 signaling pathway
sbq04068  FoxO signaling pathway
sbq04070  Phosphatidylinositol signaling system
sbq04071  Sphingolipid signaling pathway
sbq04072  Phospholipase D signaling pathway
sbq04081  Hormone signaling
sbq04140  Autophagy - animal
sbq04145  Phagocytosis
sbq04150  mTOR signaling pathway
sbq04151  PI3K-Akt signaling pathway
sbq04152  AMPK signaling pathway
sbq04210  Apoptosis
sbq04211  Longevity regulating pathway
sbq04213  Longevity regulating pathway - multiple species
sbq04218  Cellular senescence
sbq04360  Axon guidance
sbq04370  VEGF signaling pathway
sbq04380  Osteoclast differentiation
sbq04510  Focal adhesion
sbq04517  IgSF CAM signaling
sbq04518  Integrin signaling
sbq04550  Signaling pathways regulating pluripotency of stem cells
sbq04611  Platelet activation
sbq04613  Neutrophil extracellular trap formation
sbq04620  Toll-like receptor signaling pathway
sbq04625  C-type lectin receptor signaling pathway
sbq04630  JAK-STAT signaling pathway
sbq04650  Natural killer cell mediated cytotoxicity
sbq04660  T cell receptor signaling pathway
sbq04662  B cell receptor signaling pathway
sbq04664  Fc epsilon RI signaling pathway
sbq04666  Fc gamma R-mediated phagosome formation
sbq04668  TNF signaling pathway
sbq04670  Leukocyte transendothelial migration
sbq04722  Neurotrophin signaling pathway
sbq04725  Cholinergic synapse
sbq04750  Inflammatory mediator regulation of TRP channels
sbq04810  Regulation of actin cytoskeleton
sbq04910  Insulin signaling pathway
sbq04914  Progesterone-mediated oocyte maturation
sbq04915  Estrogen signaling pathway
sbq04917  Prolactin signaling pathway
sbq04919  Thyroid hormone signaling pathway
sbq04923  Regulation of lipolysis in adipocytes
sbq04926  Relaxin signaling pathway
sbq04929  GnRH secretion
sbq04930  Type II diabetes mellitus
sbq04931  Insulin resistance
sbq04932  Non-alcoholic fatty liver disease
sbq04933  AGE-RAGE signaling pathway in diabetic complications
sbq04935  Growth hormone synthesis, secretion and action
sbq04960  Aldosterone-regulated sodium reabsorption
sbq04973  Carbohydrate digestion and absorption
sbq05010  Alzheimer disease
sbq05017  Spinocerebellar ataxia
sbq05020  Prion disease
sbq05100  Bacterial invasion of epithelial cells
sbq05132  Salmonella infection
sbq05135  Yersinia infection
sbq05142  Chagas disease
sbq05146  Amoebiasis
sbq05160  Hepatitis C
sbq05161  Hepatitis B
sbq05162  Measles
sbq05163  Human cytomegalovirus infection
sbq05164  Influenza A
sbq05165  Human papillomavirus infection
sbq05166  Human T-cell leukemia virus 1 infection
sbq05167  Kaposi sarcoma-associated herpesvirus infection
sbq05168  Herpes simplex virus 1 infection
sbq05169  Epstein-Barr virus infection
sbq05170  Human immunodeficiency virus 1 infection
sbq05171  Coronavirus disease
sbq05200  Pathways in cancer
sbq05203  Viral carcinogenesis
sbq05205  Proteoglycans in cancer
sbq05206  MicroRNAs in cancer
sbq05207  Chemical carcinogenesis - receptor activation
sbq05208  Chemical carcinogenesis - reactive oxygen species
sbq05210  Colorectal cancer
sbq05211  Renal cell carcinoma
sbq05212  Pancreatic cancer
sbq05213  Endometrial cancer
sbq05214  Glioma
sbq05215  Prostate cancer
sbq05218  Melanoma
sbq05220  Chronic myeloid leukemia
sbq05221  Acute myeloid leukemia
sbq05222  Small cell lung cancer
sbq05223  Non-small cell lung cancer
sbq05224  Breast cancer
sbq05225  Hepatocellular carcinoma
sbq05226  Gastric cancer
sbq05230  Central carbon metabolism in cancer
sbq05231  Choline metabolism in cancer
sbq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
sbq05415  Diabetic cardiomyopathy
sbq05417  Lipid and atherosclerosis
sbq05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:sbq00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101027982 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101027982 (PIK3CB)
   04014 Ras signaling pathway
    101027982 (PIK3CB)
   04015 Rap1 signaling pathway
    101027982 (PIK3CB)
   04370 VEGF signaling pathway
    101027982 (PIK3CB)
   04630 JAK-STAT signaling pathway
    101027982 (PIK3CB)
   04668 TNF signaling pathway
    101027982 (PIK3CB)
   04066 HIF-1 signaling pathway
    101027982 (PIK3CB)
   04068 FoxO signaling pathway
    101027982 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    101027982 (PIK3CB)
   04072 Phospholipase D signaling pathway
    101027982 (PIK3CB)
   04071 Sphingolipid signaling pathway
    101027982 (PIK3CB)
   04024 cAMP signaling pathway
    101027982 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    101027982 (PIK3CB)
   04152 AMPK signaling pathway
    101027982 (PIK3CB)
   04150 mTOR signaling pathway
    101027982 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101027982 (PIK3CB)
   04517 IgSF CAM signaling
    101027982 (PIK3CB)
   04518 Integrin signaling
    101027982 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    101027982 (PIK3CB)
   04140 Autophagy - animal
    101027982 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    101027982 (PIK3CB)
   04218 Cellular senescence
    101027982 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101027982 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    101027982 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101027982 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101027982 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    101027982 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    101027982 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    101027982 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    101027982 (PIK3CB)
   04660 T cell receptor signaling pathway
    101027982 (PIK3CB)
   04662 B cell receptor signaling pathway
    101027982 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    101027982 (PIK3CB)
   04666 Fc gamma R-mediated phagosome formation
    101027982 (PIK3CB)
   04670 Leukocyte transendothelial migration
    101027982 (PIK3CB)
   04062 Chemokine signaling pathway
    101027982 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101027982 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    101027982 (PIK3CB)
   04929 GnRH secretion
    101027982 (PIK3CB)
   04915 Estrogen signaling pathway
    101027982 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    101027982 (PIK3CB)
   04917 Prolactin signaling pathway
    101027982 (PIK3CB)
   04926 Relaxin signaling pathway
    101027982 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    101027982 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    101027982 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101027982 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101027982 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    101027982 (PIK3CB)
   04722 Neurotrophin signaling pathway
    101027982 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101027982 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    101027982 (PIK3CB)
   04380 Osteoclast differentiation
    101027982 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    101027982 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    101027982 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101027982 (PIK3CB)
   05206 MicroRNAs in cancer
    101027982 (PIK3CB)
   05205 Proteoglycans in cancer
    101027982 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    101027982 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    101027982 (PIK3CB)
   05203 Viral carcinogenesis
    101027982 (PIK3CB)
   05230 Central carbon metabolism in cancer
    101027982 (PIK3CB)
   05231 Choline metabolism in cancer
    101027982 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101027982 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101027982 (PIK3CB)
   05212 Pancreatic cancer
    101027982 (PIK3CB)
   05225 Hepatocellular carcinoma
    101027982 (PIK3CB)
   05226 Gastric cancer
    101027982 (PIK3CB)
   05214 Glioma
    101027982 (PIK3CB)
   05221 Acute myeloid leukemia
    101027982 (PIK3CB)
   05220 Chronic myeloid leukemia
    101027982 (PIK3CB)
   05218 Melanoma
    101027982 (PIK3CB)
   05211 Renal cell carcinoma
    101027982 (PIK3CB)
   05215 Prostate cancer
    101027982 (PIK3CB)
   05213 Endometrial cancer
    101027982 (PIK3CB)
   05224 Breast cancer
    101027982 (PIK3CB)
   05222 Small cell lung cancer
    101027982 (PIK3CB)
   05223 Non-small cell lung cancer
    101027982 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101027982 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    101027982 (PIK3CB)
   05161 Hepatitis B
    101027982 (PIK3CB)
   05160 Hepatitis C
    101027982 (PIK3CB)
   05171 Coronavirus disease
    101027982 (PIK3CB)
   05164 Influenza A
    101027982 (PIK3CB)
   05162 Measles
    101027982 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    101027982 (PIK3CB)
   05163 Human cytomegalovirus infection
    101027982 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101027982 (PIK3CB)
   05169 Epstein-Barr virus infection
    101027982 (PIK3CB)
   05165 Human papillomavirus infection
    101027982 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101027982 (PIK3CB)
   05135 Yersinia infection
    101027982 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    101027982 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101027982 (PIK3CB)
   05142 Chagas disease
    101027982 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101027982 (PIK3CB)
   05017 Spinocerebellar ataxia
    101027982 (PIK3CB)
   05020 Prion disease
    101027982 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101027982 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    101027982 (PIK3CB)
   05415 Diabetic cardiomyopathy
    101027982 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101027982 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    101027982 (PIK3CB)
   04931 Insulin resistance
    101027982 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101027982 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101027982 (PIK3CB)
   01524 Platinum drug resistance
    101027982 (PIK3CB)
   01522 Endocrine resistance
    101027982 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:sbq04131]
    101027982 (PIK3CB)
Enzymes [BR:sbq01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101027982 (PIK3CB)
Membrane trafficking [BR:sbq04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101027982 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 LepB_N DUF4381
Other DBs
NCBI-GeneID: 101027982
NCBI-ProteinID: XP_003931023
UniProt: A0A2K6SKI4
Position
Unknown
AA seq 1070 aa
MCFGFIMPPAMADILDIWAVDSQIASDGTIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDGLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENSQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
ISPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVVNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIIYHVWENNNPFQIILVKGNKLNTEETVKVHVRAGLFHG
TELLCKTVVSSEVSGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKAKTKKSTKAI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcggtttcataatgcctcctgctatggcagacatccttgacatctgggcggtg
gattcacagatagcatctgatggcaccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaattacccaatgttcaaccttcttatggaaattgactcctatatgttt
gcatgtgtgaatcagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgatccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctccatgaatttgatggcttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagcgaggaaaagatc
ctgtcacttgtgggattatcttggatggactggctaaaacaaacatatccaccagagcat
gaaccatccatccctgaaaacttagaagataaactttatggaggaaagctcattgtagct
gttcattttgaaaactcccaggatgtgtttagctttcaagtatctccgaatatgaatcct
ataaaagtaaatgaattggcaatccagaaacgtttgactattcatgggaaggaagatgaa
attagcccctatgattatgtgttgcaagtcagtgggagagtagaatatgtttttggtgat
catccactaattcagttccagtatatccggaactgtgtagtgaacaggaccctgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaggaaatgattgccata
gaggctgccataaatagaaattcatctaatcttcctcttccattaccaccaaagaaaaca
cgaattatttatcatgtttgggaaaataacaaccctttccaaattatcttggttaaggga
aataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgagctcctgtgtaaaacagtcgtaagctctgaggtatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatatcaatacttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgcagttttggataaagcaaaaacaaagaaatcaacgaaagctatt
aatccctctaaatatcagaccatcaggaaagctggaaaagtgcattatcctgtagcctgg
gtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatattacac
agctggtcttcatttccagatgaacttgaagaaatgttgaatccaatgggaactgttcag
acaaatccatatactgaaaatgcaacagctttgcatattaaatttccagagaataaaaaa
caaccttattattaccctcccttcgataagattattgaaaaggcagctgagattgcaagc
agtgatagtgctaatgtgtcaagtcgaggaggaaaaaagtttcttcctgtattgaaagaa
atcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggact
ttgcgacaagactgccgagagaatttcccacagtcactgccaaagttactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcactgcttcagatttggcctaaa
ctgcccccgcgggaggccctggagcttctggatttcaactatccagaccagtacgttcga
gaatatgctgtaggctgcctgcgacagatgagtgatgaagaactttctcaatatctttta
caactggtgcaagttttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttgctaatcggaggatagggcagtttctattttggcatcttaggtcg
gaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatactgccgg
ggaagtgtggggcacatgaaagtgctttccaagcaggttgaagccctcaataagttaaaa
actttaaatagtttaatcaaactgaatgcagtgaagttaaacagagccaaagggaaggag
gccatgcacacctgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtca
cccctgaacccatgtgttatcctctcggaactctatgttgaaaaatgcaaatacatggat
tccaaaatgaagcctttgtggctggtgtacaataacaaggtatttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccaaatgttg
cgcttgatggatttactctggaaagaagctggtttggatcttcggatgttgccttacggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgctgcagccttcaacaaagatgcc
cttctgaattggctcaaagaatacaattctggggatgacctggaccgagccattgaggaa
tttactctgtcctgtgctggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgattttggacat
attcttggaaatttcaaatcaaagtttggcattaaaagggagcgagtgccttttattctt
acctatgatttcatccatgtcattcagcaaggaaaaacaggaaatacagaaaagtttggc
cggttccgtcagtgttgtgaggatgcatatctgattttacgacggcatgggaatctcttc
atcactctctttgcattgatgttgactgcagggcttcctgaactcacatcagtcaaggat
atacagtatcttaaggactctcttgcattagggaagagtgaagaagaagcactcaaacag
tttaaacaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   RefSeq(pep) (7)   
DNA sequence (7)   
   RefSeq(nuc) (7)   
Protein domain (7)   
   Pfam (7)   
All databases (25)   

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