KEGG   PATHWAY: sens03440
Entry
sens03440                   Pathway                                

Name
Homologous recombination - Salmonella enterica subsp. enterica serovar Agona 24249
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
sens03440  Homologous recombination
sens03440

Other DBs
GO: 0000724
Organism
Salmonella enterica subsp. enterica serovar Agona 24249 [GN:sens]
Gene
Q786_14720  ssDNA exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Q786_20880  single-stranded DNA-binding protein [KO:K03111]
Q786_18805  recF; recombinase F [KO:K03629]
Q786_12765  recO; DNA repair protein RecO [KO:K03584]
Q786_02395  recR; recombinase RecR [KO:K06187]
Q786_13600  recA; recombinase RecA [KO:K03553]
Q786_19605  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Q786_05725  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
Q786_05730  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
Q786_05710  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
Q786_18310  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
Q786_14475  recB; exonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
Q786_14485  recC; exonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
Q786_14470  recD; exonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
Q786_01215  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
Q786_18810  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
Q786_02385  DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Q786_03165  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
Q786_09255  DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
Q786_01380  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
Q786_05825  DNA polymerase III subunit theta [KO:K02345] [EC:2.7.7.7]
Q786_22055  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
Q786_20105  primosome assembly protein PriA [KO:K04066] [EC:3.6.4.-]
Q786_21635  primosomal replication protein N [KO:K02686]
Q786_02370  primosomal replication protein N'' [KO:K04067]
Q786_22505  primosomal protein DnaI [KO:K02317]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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