KEGG   Suncus etruscus (white-toothed pygmy shrew): 126012035
Entry
126012035         CDS       T09902                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
setr  Suncus etruscus (white-toothed pygmy shrew)
Pathway
setr00562  Inositol phosphate metabolism
setr01100  Metabolic pathways
setr01521  EGFR tyrosine kinase inhibitor resistance
setr01522  Endocrine resistance
setr01524  Platinum drug resistance
setr04012  ErbB signaling pathway
setr04014  Ras signaling pathway
setr04015  Rap1 signaling pathway
setr04024  cAMP signaling pathway
setr04062  Chemokine signaling pathway
setr04066  HIF-1 signaling pathway
setr04068  FoxO signaling pathway
setr04070  Phosphatidylinositol signaling system
setr04071  Sphingolipid signaling pathway
setr04072  Phospholipase D signaling pathway
setr04081  Hormone signaling
setr04140  Autophagy - animal
setr04145  Phagocytosis
setr04150  mTOR signaling pathway
setr04151  PI3K-Akt signaling pathway
setr04152  AMPK signaling pathway
setr04210  Apoptosis
setr04211  Longevity regulating pathway
setr04213  Longevity regulating pathway - multiple species
setr04218  Cellular senescence
setr04360  Axon guidance
setr04370  VEGF signaling pathway
setr04380  Osteoclast differentiation
setr04510  Focal adhesion
setr04517  IgSF CAM signaling
setr04518  Integrin signaling
setr04550  Signaling pathways regulating pluripotency of stem cells
setr04611  Platelet activation
setr04613  Neutrophil extracellular trap formation
setr04620  Toll-like receptor signaling pathway
setr04625  C-type lectin receptor signaling pathway
setr04630  JAK-STAT signaling pathway
setr04650  Natural killer cell mediated cytotoxicity
setr04660  T cell receptor signaling pathway
setr04662  B cell receptor signaling pathway
setr04664  Fc epsilon RI signaling pathway
setr04666  Fc gamma R-mediated phagosome formation
setr04668  TNF signaling pathway
setr04670  Leukocyte transendothelial migration
setr04722  Neurotrophin signaling pathway
setr04725  Cholinergic synapse
setr04750  Inflammatory mediator regulation of TRP channels
setr04810  Regulation of actin cytoskeleton
setr04910  Insulin signaling pathway
setr04914  Progesterone-mediated oocyte maturation
setr04915  Estrogen signaling pathway
setr04917  Prolactin signaling pathway
setr04919  Thyroid hormone signaling pathway
setr04923  Regulation of lipolysis in adipocytes
setr04926  Relaxin signaling pathway
setr04929  GnRH secretion
setr04930  Type II diabetes mellitus
setr04931  Insulin resistance
setr04932  Non-alcoholic fatty liver disease
setr04933  AGE-RAGE signaling pathway in diabetic complications
setr04935  Growth hormone synthesis, secretion and action
setr04960  Aldosterone-regulated sodium reabsorption
setr04973  Carbohydrate digestion and absorption
setr05010  Alzheimer disease
setr05017  Spinocerebellar ataxia
setr05020  Prion disease
setr05100  Bacterial invasion of epithelial cells
setr05132  Salmonella infection
setr05135  Yersinia infection
setr05142  Chagas disease
setr05146  Amoebiasis
setr05160  Hepatitis C
setr05161  Hepatitis B
setr05162  Measles
setr05163  Human cytomegalovirus infection
setr05164  Influenza A
setr05165  Human papillomavirus infection
setr05166  Human T-cell leukemia virus 1 infection
setr05167  Kaposi sarcoma-associated herpesvirus infection
setr05168  Herpes simplex virus 1 infection
setr05169  Epstein-Barr virus infection
setr05170  Human immunodeficiency virus 1 infection
setr05171  Coronavirus disease
setr05200  Pathways in cancer
setr05203  Viral carcinogenesis
setr05205  Proteoglycans in cancer
setr05206  MicroRNAs in cancer
setr05207  Chemical carcinogenesis - receptor activation
setr05208  Chemical carcinogenesis - reactive oxygen species
setr05210  Colorectal cancer
setr05211  Renal cell carcinoma
setr05212  Pancreatic cancer
setr05213  Endometrial cancer
setr05214  Glioma
setr05215  Prostate cancer
setr05218  Melanoma
setr05220  Chronic myeloid leukemia
setr05221  Acute myeloid leukemia
setr05222  Small cell lung cancer
setr05223  Non-small cell lung cancer
setr05224  Breast cancer
setr05225  Hepatocellular carcinoma
setr05226  Gastric cancer
setr05230  Central carbon metabolism in cancer
setr05231  Choline metabolism in cancer
setr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
setr05415  Diabetic cardiomyopathy
setr05417  Lipid and atherosclerosis
setr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:setr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    126012035 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    126012035 (PIK3CB)
   04014 Ras signaling pathway
    126012035 (PIK3CB)
   04015 Rap1 signaling pathway
    126012035 (PIK3CB)
   04370 VEGF signaling pathway
    126012035 (PIK3CB)
   04630 JAK-STAT signaling pathway
    126012035 (PIK3CB)
   04668 TNF signaling pathway
    126012035 (PIK3CB)
   04066 HIF-1 signaling pathway
    126012035 (PIK3CB)
   04068 FoxO signaling pathway
    126012035 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    126012035 (PIK3CB)
   04072 Phospholipase D signaling pathway
    126012035 (PIK3CB)
   04071 Sphingolipid signaling pathway
    126012035 (PIK3CB)
   04024 cAMP signaling pathway
    126012035 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    126012035 (PIK3CB)
   04152 AMPK signaling pathway
    126012035 (PIK3CB)
   04150 mTOR signaling pathway
    126012035 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    126012035 (PIK3CB)
   04517 IgSF CAM signaling
    126012035 (PIK3CB)
   04518 Integrin signaling
    126012035 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    126012035 (PIK3CB)
   04140 Autophagy - animal
    126012035 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    126012035 (PIK3CB)
   04218 Cellular senescence
    126012035 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    126012035 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    126012035 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    126012035 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    126012035 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    126012035 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    126012035 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    126012035 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    126012035 (PIK3CB)
   04660 T cell receptor signaling pathway
    126012035 (PIK3CB)
   04662 B cell receptor signaling pathway
    126012035 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    126012035 (PIK3CB)
   04666 Fc gamma R-mediated phagosome formation
    126012035 (PIK3CB)
   04670 Leukocyte transendothelial migration
    126012035 (PIK3CB)
   04062 Chemokine signaling pathway
    126012035 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    126012035 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    126012035 (PIK3CB)
   04929 GnRH secretion
    126012035 (PIK3CB)
   04915 Estrogen signaling pathway
    126012035 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    126012035 (PIK3CB)
   04917 Prolactin signaling pathway
    126012035 (PIK3CB)
   04926 Relaxin signaling pathway
    126012035 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    126012035 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    126012035 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    126012035 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    126012035 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    126012035 (PIK3CB)
   04722 Neurotrophin signaling pathway
    126012035 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    126012035 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    126012035 (PIK3CB)
   04380 Osteoclast differentiation
    126012035 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    126012035 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    126012035 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    126012035 (PIK3CB)
   05206 MicroRNAs in cancer
    126012035 (PIK3CB)
   05205 Proteoglycans in cancer
    126012035 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    126012035 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    126012035 (PIK3CB)
   05203 Viral carcinogenesis
    126012035 (PIK3CB)
   05230 Central carbon metabolism in cancer
    126012035 (PIK3CB)
   05231 Choline metabolism in cancer
    126012035 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    126012035 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    126012035 (PIK3CB)
   05212 Pancreatic cancer
    126012035 (PIK3CB)
   05225 Hepatocellular carcinoma
    126012035 (PIK3CB)
   05226 Gastric cancer
    126012035 (PIK3CB)
   05214 Glioma
    126012035 (PIK3CB)
   05221 Acute myeloid leukemia
    126012035 (PIK3CB)
   05220 Chronic myeloid leukemia
    126012035 (PIK3CB)
   05218 Melanoma
    126012035 (PIK3CB)
   05211 Renal cell carcinoma
    126012035 (PIK3CB)
   05215 Prostate cancer
    126012035 (PIK3CB)
   05213 Endometrial cancer
    126012035 (PIK3CB)
   05224 Breast cancer
    126012035 (PIK3CB)
   05222 Small cell lung cancer
    126012035 (PIK3CB)
   05223 Non-small cell lung cancer
    126012035 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    126012035 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    126012035 (PIK3CB)
   05161 Hepatitis B
    126012035 (PIK3CB)
   05160 Hepatitis C
    126012035 (PIK3CB)
   05171 Coronavirus disease
    126012035 (PIK3CB)
   05164 Influenza A
    126012035 (PIK3CB)
   05162 Measles
    126012035 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    126012035 (PIK3CB)
   05163 Human cytomegalovirus infection
    126012035 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    126012035 (PIK3CB)
   05169 Epstein-Barr virus infection
    126012035 (PIK3CB)
   05165 Human papillomavirus infection
    126012035 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    126012035 (PIK3CB)
   05135 Yersinia infection
    126012035 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    126012035 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    126012035 (PIK3CB)
   05142 Chagas disease
    126012035 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    126012035 (PIK3CB)
   05017 Spinocerebellar ataxia
    126012035 (PIK3CB)
   05020 Prion disease
    126012035 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    126012035 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    126012035 (PIK3CB)
   05415 Diabetic cardiomyopathy
    126012035 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    126012035 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    126012035 (PIK3CB)
   04931 Insulin resistance
    126012035 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    126012035 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    126012035 (PIK3CB)
   01524 Platinum drug resistance
    126012035 (PIK3CB)
   01522 Endocrine resistance
    126012035 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:setr04131]
    126012035 (PIK3CB)
Enzymes [BR:setr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     126012035 (PIK3CB)
Membrane trafficking [BR:setr04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    126012035 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381 LepB_N
Other DBs
NCBI-GeneID: 126012035
NCBI-ProteinID: XP_049631776
Position
6:98578346..98652942
AA seq 1070 aa
MCFCVTMSPAMADTLDIWAVDSQIAADGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFHLLMEIDSYMFACVNQTAVYEELEDESRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRVKMRKFSEEKLHSLVGLSWIDWLKQTYPPEH
ETSVLENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHIFENSNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEISGKNDYVWNETLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGDSILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKHPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGYMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQNAYREALSGLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttctgtgtcacaatgtctcctgctatggcagacacccttgacatctgggcagtg
gattcacagatagcagcagatggctccattcctgtggatttccttttgcccactggaatc
tatatacagttggaggtacctcgggaagccaccatttcctatattaaacagatgttgtgg
aagcaagttcacaactaccccatgtttcaccttctgatggaaatcgactcctatatgttt
gcatgtgtgaatcaaactgctgtctacgaggagctcgaggatgaatctagaaggctctgc
gacgtcagacctttccttccagttctaaaattagtgacaagaagttgtgatccaggggaa
aaattagactcaaaaatcggagtcctgataggaaaaggtctacatgaatttgatgctttg
aaagatccagaagtgaatgagtttcgtgtaaaaatgcgcaaattcagtgaggaaaagcta
cattcacttgtaggattgtcttggattgattggctaaagcagacataccccccagagcat
gaaacatctgtcctcgaaaacttagaagataaactttatggaggaaagcttattgtggct
gttcactttgaaaactgtcaggatgtatttagctttcaagtatctcctaatatgaatcct
attaaagtaaatgaattggcaatccaaaaacgtttgactattcatggaaaagaagatgaa
gtcagtccatatgattatgtgttacaagtcagcgggagagtggaatatgtgttcggtgat
cacccattaattcaattccagtatatacggaactgtgtaatgaacaggaccttgccccat
tttatacttgtggaatgctgcaaaattaagaagatgtatgaacaggaaatgattgctata
gaggctgccataaatcgaaattcgtctaatcttcctcttcctttaccaccaaagaaaaca
cgaattatatctcatatttttgaaaatagtaatcctttccaaattgtcttggttaagggg
aataaacttaacacagaagaaactgtaaaagttcacgtcagggctggtctttttcatggt
actgaactcttatgcaaaaccattgtaagctcagaaatatcagggaaaaatgactacgtt
tggaatgaaacactggaatttgatattaatacttgtgacctgccaagaatggctcgatta
tgttttgctgtttatgcagttttggataaagtgaaaacgaagaaatcaactaaaactatt
aatccctctaaatatcaaaccatcaggaaggctgggaaagtgcattatcctgtagcctgg
gtaaataccatggtttttgactttaaaggacagctgcggtctggagatagcatattgcat
agttggtcttcgtttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
actaatccatacactgaaaatgcaacagctttacatattaagttcccagagaataaaaag
catccctattactaccctccctttgataagatcatcgaaaaggcagctgaaatcgcaagc
agtgacagtgctaatgtatcaagtcgaggcggaaaaaaatttcttgctgtactcaaagaa
atcttggacagggatcccttgtctcagttgtgtgagaatgaaatggatcttatttggact
ttgaggcaagactgtagagagaatttcccacagtcactgccaaaattactgctatcaatc
aagtggaataaacttgaagatgttgcccagcttcaggcgcttcttcaaatttggcctaaa
ttgcccccacgagaggctttggagcttctggatttcaactacccagaccagtatgtgcga
gaatatgcggtaggctgtctccgacaaatgagtgatgaagagctctcccagtatcttctc
cagctggtgcaagtcttgaagtatgagccttttcttgactgcgccctctctaggttcctg
ctagaaagagcacttgctaaccggaggataggccagtttttgttttggcaccttaggtca
gaagtgcacatccctgctgtttcagtccagtttggtgtcatcctggaggcgtactgccgg
ggcagtgtagggtacatgaaagtgctgtccaaacaggttgaagcactcaataagttaaaa
actttaaacagtttgatcaaactgaatgcggtgaagctaaacagagccaaagggaaagaa
gccatgcacacttgtttgaagcagaatgcgtaccgggaagccctctcaggtctgcagtcg
cctctgaacccctgtgtgatcctctccgaactctatgttgaaaagtgtaaatacatggat
tccaaaatgaaacccttgtggctagtctacaacaacaaggtgtttggtgaggattcagtc
ggagtcatttttaaaaatggtgatgatttacgacaagatatgctaacactgcaaatgctt
cgcttaatggatttactctggaaagaagctggactggatcttcggatgctgccttacggc
tgtcttgcaactggagaccgctctggcctcatcgaggttgtgagcacctcggaaacaatc
gctgacattcagctgaacagtagcaacgtggctgctgcagcagccttcaataaagacgcc
cttctgaactggctgaaggagtacaattccggggatgacctggaccgagccattgaggag
tttactctgtcctgtgccggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgataacatcatggtcaagaagactgggcagctcttccacattgacttcggacat
attcttggaaatttcaagtccaaatttggcattaaaagggaacgagtgccttttattctc
acctatgatttcattcatgtgattcaacaaggaaaaacgggaaacacagaaaagtttggc
cggttccggcagtgctgtgaggatgcgtacctgattttgcggaggcacgggaatctcttt
atcactctctttgcattgatgctgactgcagggctgcctgaactcacatcagtcaaggac
atacaatatcttaaggattctcttgcattagggaagagtgaagaagaagcactcaaacaa
ttcaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacggtccggaaagattaccggtcctaa

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (11)   

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