KEGG   Trichechus manatus latirostris (Florida manatee): 101344242
Entry
101344242         CDS       T05135                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
tmu  Trichechus manatus latirostris (Florida manatee)
Pathway
tmu00562  Inositol phosphate metabolism
tmu01100  Metabolic pathways
tmu04015  Rap1 signaling pathway
tmu04020  Calcium signaling pathway
tmu04022  cGMP-PKG signaling pathway
tmu04062  Chemokine signaling pathway
tmu04070  Phosphatidylinositol signaling system
tmu04071  Sphingolipid signaling pathway
tmu04072  Phospholipase D signaling pathway
tmu04081  Hormone signaling
tmu04082  Neuroactive ligand signaling
tmu04261  Adrenergic signaling in cardiomyocytes
tmu04270  Vascular smooth muscle contraction
tmu04310  Wnt signaling pathway
tmu04371  Apelin signaling pathway
tmu04540  Gap junction
tmu04611  Platelet activation
tmu04613  Neutrophil extracellular trap formation
tmu04621  NOD-like receptor signaling pathway
tmu04713  Circadian entrainment
tmu04720  Long-term potentiation
tmu04723  Retrograde endocannabinoid signaling
tmu04724  Glutamatergic synapse
tmu04725  Cholinergic synapse
tmu04726  Serotonergic synapse
tmu04728  Dopaminergic synapse
tmu04730  Long-term depression
tmu04742  Taste transduction
tmu04750  Inflammatory mediator regulation of TRP channels
tmu04911  Insulin secretion
tmu04912  GnRH signaling pathway
tmu04915  Estrogen signaling pathway
tmu04916  Melanogenesis
tmu04918  Thyroid hormone synthesis
tmu04919  Thyroid hormone signaling pathway
tmu04921  Oxytocin signaling pathway
tmu04922  Glucagon signaling pathway
tmu04924  Renin secretion
tmu04925  Aldosterone synthesis and secretion
tmu04926  Relaxin signaling pathway
tmu04927  Cortisol synthesis and secretion
tmu04928  Parathyroid hormone synthesis, secretion and action
tmu04929  GnRH secretion
tmu04933  AGE-RAGE signaling pathway in diabetic complications
tmu04934  Cushing syndrome
tmu04935  Growth hormone synthesis, secretion and action
tmu04961  Endocrine and other factor-regulated calcium reabsorption
tmu04970  Salivary secretion
tmu04971  Gastric acid secretion
tmu04972  Pancreatic secretion
tmu04973  Carbohydrate digestion and absorption
tmu05010  Alzheimer disease
tmu05016  Huntington disease
tmu05017  Spinocerebellar ataxia
tmu05022  Pathways of neurodegeneration - multiple diseases
tmu05142  Chagas disease
tmu05143  African trypanosomiasis
tmu05146  Amoebiasis
tmu05163  Human cytomegalovirus infection
tmu05200  Pathways in cancer
tmu05415  Diabetic cardiomyopathy
tmu05417  Lipid and atherosclerosis
Module
tmu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:tmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101344242
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101344242
   04310 Wnt signaling pathway
    101344242
   04371 Apelin signaling pathway
    101344242
   04020 Calcium signaling pathway
    101344242
   04070 Phosphatidylinositol signaling system
    101344242
   04072 Phospholipase D signaling pathway
    101344242
   04071 Sphingolipid signaling pathway
    101344242
   04022 cGMP-PKG signaling pathway
    101344242
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    101344242
   04081 Hormone signaling
    101344242
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101344242
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101344242
   04613 Neutrophil extracellular trap formation
    101344242
   04621 NOD-like receptor signaling pathway
    101344242
   04062 Chemokine signaling pathway
    101344242
  09152 Endocrine system
   04911 Insulin secretion
    101344242
   04922 Glucagon signaling pathway
    101344242
   04929 GnRH secretion
    101344242
   04912 GnRH signaling pathway
    101344242
   04915 Estrogen signaling pathway
    101344242
   04921 Oxytocin signaling pathway
    101344242
   04926 Relaxin signaling pathway
    101344242
   04935 Growth hormone synthesis, secretion and action
    101344242
   04918 Thyroid hormone synthesis
    101344242
   04919 Thyroid hormone signaling pathway
    101344242
   04928 Parathyroid hormone synthesis, secretion and action
    101344242
   04916 Melanogenesis
    101344242
   04924 Renin secretion
    101344242
   04925 Aldosterone synthesis and secretion
    101344242
   04927 Cortisol synthesis and secretion
    101344242
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101344242
   04270 Vascular smooth muscle contraction
    101344242
  09154 Digestive system
   04970 Salivary secretion
    101344242
   04971 Gastric acid secretion
    101344242
   04972 Pancreatic secretion
    101344242
   04973 Carbohydrate digestion and absorption
    101344242
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101344242
  09156 Nervous system
   04724 Glutamatergic synapse
    101344242
   04725 Cholinergic synapse
    101344242
   04728 Dopaminergic synapse
    101344242
   04726 Serotonergic synapse
    101344242
   04720 Long-term potentiation
    101344242
   04730 Long-term depression
    101344242
   04723 Retrograde endocannabinoid signaling
    101344242
  09157 Sensory system
   04742 Taste transduction
    101344242
   04750 Inflammatory mediator regulation of TRP channels
    101344242
  09159 Environmental adaptation
   04713 Circadian entrainment
    101344242
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101344242
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    101344242
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101344242
   05142 Chagas disease
    101344242
   05143 African trypanosomiasis
    101344242
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101344242
   05016 Huntington disease
    101344242
   05017 Spinocerebellar ataxia
    101344242
   05022 Pathways of neurodegeneration - multiple diseases
    101344242
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101344242
   05415 Diabetic cardiomyopathy
    101344242
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101344242
   04934 Cushing syndrome
    101344242
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tmu04131]
    101344242
Enzymes [BR:tmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101344242
Membrane trafficking [BR:tmu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101344242
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101344242
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 GP24_25 DUF8110
Other DBs
NCBI-GeneID: 101344242
NCBI-ProteinID: XP_023594005
UniProt: A0A2Y9RFD8
Position
Unknown
AA seq 1226 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEESSSRNLVTLRVDPNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLITVVAGPDPVNTTFLNF
MAVQDDTAKIWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLDIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNKQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQTLLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHPPSTGVPDS
SVRKRPLEQSNSALSEISAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPRKSLGD
EGLRQGPDALGSADREYEEEDEEEEEQTDPKKLTSDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKALEQLKESPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRVLPVSAIRSGYHYVCLRNEANQPLCLPALLV
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGENEAGPETSQEPQSQQLGA
HLPLNATLSQLEMSASRTQVSVTSSTSSSLSSPGQRDDLVASILSEVAPTPLDELRGHKA
LVKLRSRQERDLRELLKKQQRKALAFSRRLLNNLAQVRAEGRSRRRGGSAEEDKDEQEEV
KRYQEFQKRQIQSLLELREAQVDAEADRRLEHLRQAQHRLREVVLEAHMTQLKRLKELNE
REKKDLQKILDRKRHNSISEAKTREKYKKEVELTEINRRHITESVNSIRRLEEAQKQRHD
CLVAAQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRQSLLGETPEGLGDGHLVACA
SNGHAPGSSSHLSGTDSENQEENTKL
NT seq 3681 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggagtcttctagtcggaacctg
gttaccctgcgcgtggaccccaatggcttctttctgtactggacgggacccaacatggag
gtggacacactggacatcagctccatccgggacacgcggactggtcgctacgcccgccta
cccaaggaccccaagatccgggaggtgctgggctttgggggtcccgatgcccggctggag
gagaagctgataacggtggtggctgggccagacccggtgaacacgacgttcttgaacttc
atggccgtgcaggatgacacagccaagatctggtccgaggagctgttcaagctggctatg
aacatcctggctcagaacgcctcccggaacaccttcctacgcaaagcatacacgaagctg
aagctgcaggtgaaccaggatgggcgaatccctgtcaagaacatcctgaagatgttctca
gcagacaagaagcgggtggagaccgcgctggaatcctgcggcctcaatttcaaccggagt
gagtccatccggcctgacgagttttccttggacatctttgagcggttcctgaacaagctg
tgtctgcggccggacatcgacaagatcctgctggagataggtgccaaggggaagccgtac
ctgacactggagcagctcatggacttcatcaaccagaagcagcgtgacccgagactcaac
gaagtgctgtacccaccgctgcggccctcgcaggcgcggctgctcatcgagaagtatgag
cccaacaagcagttcctggagcgagaccagatgtccatggagggctttagccgctacctg
ggaggcgaggagaatggcattctgcccctggaggccctggacctgagcgcggacatgacc
cagcccctgagcgcctatttcatcaactcctcacacaacacctatctcaccgcggggcag
ctggctgggacttcgtcggtggagatgtaccggcagacgctgctgtggggctgccgctgc
gtggagctggacgtgtggaaggggcggccgcccgaggaggagcccttcatcacccacggc
ttcaccatgaccacagaagtgccactgcgtgatgtgctcgaggccatcgctgagaccgcc
ttcaagacctcaccctaccccgtcatcctctccttcgagaaccacgtggactcggcaaag
cagcaggccaagatggctgagtactgccgctctatcttcggggacgcactgctcattgac
ccgctggacaagtacccgctggccccgggcgtccccctgcctagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagaggcacccacccagcactggcgtccccgacagc
tcggtgcgcaagcggccgctggagcagagcaactcggccctgagtgagatctctgctgcc
actgagccctcctcgccccagctcgggtcccccagctccgacagctgtccaggcctgagc
aatggggaggaggtggggcttgagaagcccagcctggagcctcggaagtctctaggggac
gaggggctgcgccagggtcctgatgctcttgggtctgctgaccgtgagtacgaggaggaa
gatgaggaagaggaggagcagacggaccccaaaaagctgacctcagatgagggcacggcc
agcagtgaggttaatgccactgaggaaatgtcaacgctggtcaactacattgagcctgtc
aagttcaagtcctttgaggctgctcgaaagaggaacaagtgctttgagatgtcatccttt
gtggagaccaaggctctggagcaactgaaggagagccccatggagtttgtggaatacaac
aagcagcagctcagccgaatctaccccaagggcacccgcgtggactcgtccaactacatg
ccccagctcttctggaatgtgggctgccagctcgtcgcgctcaacttccagaccctggat
gtggcgatgcagctcaatgcaggcgtgtttgagtacaatgggcgcagcggttacctgctg
aagcctgagttcatgcggcggccggacaagtccttcgaccccttcactgaagtcattgtg
gacggcattgtggccaacgccttacgggtcaaggtgatctcggggcagttcctgtctgac
aggaaggtgggaatctacgtggaggtggacatgtttggcctccctgttgacacgcgccgc
aagtaccgcacgcggacctcacaggggaactcgttcaatcccgtgtgggatgaggagccc
ttcgacttccccaaggtggtgctgcctacgctggcttcactccgcattgcggcctttgag
gagggcggcaagttcgtggggcaccgggttctgcccgtctctgccatccgctcagggtac
cactatgtctgcctgcggaatgaggctaaccagccgctgtgtctgccagccctgcttgtc
tacacggaggcctctgactacatccccgatgaccatcaggactacgcggaggccctgatc
aaccccatcaagcacgtcagcctgatggaccagagggccaagcagctggctgccctcatt
ggggagaatgaggctggccctgagacgagccaggagccccagtctcagcagctgggggcc
cacctgcccctgaatgccacactcagccaactggaaatgtctgccagccggacccaagtc
tctgtcacctcctctaccagttcctccctcagcagcccaggccagcgggatgatctcgtt
gccagcatcctctcagaggtggccccgaccccgctggatgagctccgaggccacaaggcg
ctggtgaagcttcggagccggcaggagcgagacctgcgggagctgctcaagaagcagcag
cggaaggcgctagccttctcccgccgtttgctcaacaacctggcgcaggtccgggccgag
ggcaggagccggcgccgaggggggtctgctgaggaggataaagatgagcaggaggaggtg
aaacggtaccaggagttccagaagaggcagatacagagtctgctggagctgagggaggcc
caggtggatgcggaggctgatcgcaggctggagcatctgagacaggctcagcatcggctc
agggaggttgtccttgaggcacacatgactcagctcaagaggctgaaggagctgaacgag
agagagaagaaggatctgcagaagatcctggacaggaaacgccataacagtatctcagag
gccaaaacaagggagaaatataagaaggaggtggaactgacagagattaatcgtcggcac
atcacggagtccgtcaactccatccgccggctggaggaggcccagaagcagcggcacgac
tgcctggtggctgcgcaacagcaggtcctacagcagctggcggaagaggagcccaagctg
ctggcccagctggcccaggagtgtcaggagcagcgggcgaggctgccccaggagatccgc
cagagcctgctgggcgagacaccggaggggctgggggacgggcatctggtggcctgtgcc
agcaatggtcacgcacccgggagcagcagccacctgtctggcactgactcggagaaccag
gaggagaacacgaagctctga

  All links  
Gene (13)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (9)   
   Pfam (9)   
All databases (25)   

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