KEGG   Talpa occidentalis (Iberian mole): 119241117
Entry
119241117         CDS       T07495                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
tod  Talpa occidentalis (Iberian mole)
Pathway
tod01521  EGFR tyrosine kinase inhibitor resistance
tod01522  Endocrine resistance
tod01524  Platinum drug resistance
tod04012  ErbB signaling pathway
tod04014  Ras signaling pathway
tod04015  Rap1 signaling pathway
tod04024  cAMP signaling pathway
tod04062  Chemokine signaling pathway
tod04066  HIF-1 signaling pathway
tod04068  FoxO signaling pathway
tod04070  Phosphatidylinositol signaling system
tod04071  Sphingolipid signaling pathway
tod04072  Phospholipase D signaling pathway
tod04081  Hormone signaling
tod04140  Autophagy - animal
tod04145  Phagocytosis
tod04150  mTOR signaling pathway
tod04151  PI3K-Akt signaling pathway
tod04152  AMPK signaling pathway
tod04210  Apoptosis
tod04211  Longevity regulating pathway
tod04213  Longevity regulating pathway - multiple species
tod04218  Cellular senescence
tod04360  Axon guidance
tod04370  VEGF signaling pathway
tod04380  Osteoclast differentiation
tod04510  Focal adhesion
tod04517  IgSF CAM signaling
tod04518  Integrin signaling
tod04550  Signaling pathways regulating pluripotency of stem cells
tod04611  Platelet activation
tod04613  Neutrophil extracellular trap formation
tod04620  Toll-like receptor signaling pathway
tod04625  C-type lectin receptor signaling pathway
tod04630  JAK-STAT signaling pathway
tod04650  Natural killer cell mediated cytotoxicity
tod04660  T cell receptor signaling pathway
tod04662  B cell receptor signaling pathway
tod04664  Fc epsilon RI signaling pathway
tod04666  Fc gamma R-mediated phagosome formation
tod04668  TNF signaling pathway
tod04670  Leukocyte transendothelial migration
tod04722  Neurotrophin signaling pathway
tod04725  Cholinergic synapse
tod04750  Inflammatory mediator regulation of TRP channels
tod04810  Regulation of actin cytoskeleton
tod04910  Insulin signaling pathway
tod04914  Progesterone-mediated oocyte maturation
tod04915  Estrogen signaling pathway
tod04917  Prolactin signaling pathway
tod04919  Thyroid hormone signaling pathway
tod04923  Regulation of lipolysis in adipocytes
tod04926  Relaxin signaling pathway
tod04929  GnRH secretion
tod04930  Type II diabetes mellitus
tod04931  Insulin resistance
tod04932  Non-alcoholic fatty liver disease
tod04933  AGE-RAGE signaling pathway in diabetic complications
tod04935  Growth hormone synthesis, secretion and action
tod04960  Aldosterone-regulated sodium reabsorption
tod04973  Carbohydrate digestion and absorption
tod05010  Alzheimer disease
tod05017  Spinocerebellar ataxia
tod05020  Prion disease
tod05100  Bacterial invasion of epithelial cells
tod05135  Yersinia infection
tod05142  Chagas disease
tod05146  Amoebiasis
tod05160  Hepatitis C
tod05161  Hepatitis B
tod05162  Measles
tod05163  Human cytomegalovirus infection
tod05164  Influenza A
tod05165  Human papillomavirus infection
tod05166  Human T-cell leukemia virus 1 infection
tod05167  Kaposi sarcoma-associated herpesvirus infection
tod05168  Herpes simplex virus 1 infection
tod05169  Epstein-Barr virus infection
tod05170  Human immunodeficiency virus 1 infection
tod05171  Coronavirus disease
tod05200  Pathways in cancer
tod05203  Viral carcinogenesis
tod05205  Proteoglycans in cancer
tod05206  MicroRNAs in cancer
tod05207  Chemical carcinogenesis - receptor activation
tod05208  Chemical carcinogenesis - reactive oxygen species
tod05210  Colorectal cancer
tod05211  Renal cell carcinoma
tod05212  Pancreatic cancer
tod05213  Endometrial cancer
tod05214  Glioma
tod05215  Prostate cancer
tod05218  Melanoma
tod05220  Chronic myeloid leukemia
tod05221  Acute myeloid leukemia
tod05222  Small cell lung cancer
tod05223  Non-small cell lung cancer
tod05224  Breast cancer
tod05225  Hepatocellular carcinoma
tod05226  Gastric cancer
tod05230  Central carbon metabolism in cancer
tod05231  Choline metabolism in cancer
tod05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tod05415  Diabetic cardiomyopathy
tod05417  Lipid and atherosclerosis
tod05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tod00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    119241117 (PIK3R2)
   04014 Ras signaling pathway
    119241117 (PIK3R2)
   04015 Rap1 signaling pathway
    119241117 (PIK3R2)
   04370 VEGF signaling pathway
    119241117 (PIK3R2)
   04630 JAK-STAT signaling pathway
    119241117 (PIK3R2)
   04668 TNF signaling pathway
    119241117 (PIK3R2)
   04066 HIF-1 signaling pathway
    119241117 (PIK3R2)
   04068 FoxO signaling pathway
    119241117 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    119241117 (PIK3R2)
   04072 Phospholipase D signaling pathway
    119241117 (PIK3R2)
   04071 Sphingolipid signaling pathway
    119241117 (PIK3R2)
   04024 cAMP signaling pathway
    119241117 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    119241117 (PIK3R2)
   04152 AMPK signaling pathway
    119241117 (PIK3R2)
   04150 mTOR signaling pathway
    119241117 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    119241117 (PIK3R2)
   04517 IgSF CAM signaling
    119241117 (PIK3R2)
   04518 Integrin signaling
    119241117 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    119241117 (PIK3R2)
   04140 Autophagy - animal
    119241117 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    119241117 (PIK3R2)
   04218 Cellular senescence
    119241117 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119241117 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    119241117 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119241117 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    119241117 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    119241117 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    119241117 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    119241117 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    119241117 (PIK3R2)
   04660 T cell receptor signaling pathway
    119241117 (PIK3R2)
   04662 B cell receptor signaling pathway
    119241117 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    119241117 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    119241117 (PIK3R2)
   04670 Leukocyte transendothelial migration
    119241117 (PIK3R2)
   04062 Chemokine signaling pathway
    119241117 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119241117 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    119241117 (PIK3R2)
   04929 GnRH secretion
    119241117 (PIK3R2)
   04915 Estrogen signaling pathway
    119241117 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    119241117 (PIK3R2)
   04917 Prolactin signaling pathway
    119241117 (PIK3R2)
   04926 Relaxin signaling pathway
    119241117 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    119241117 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    119241117 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    119241117 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    119241117 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    119241117 (PIK3R2)
   04722 Neurotrophin signaling pathway
    119241117 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    119241117 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    119241117 (PIK3R2)
   04380 Osteoclast differentiation
    119241117 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    119241117 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    119241117 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119241117 (PIK3R2)
   05206 MicroRNAs in cancer
    119241117 (PIK3R2)
   05205 Proteoglycans in cancer
    119241117 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    119241117 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    119241117 (PIK3R2)
   05203 Viral carcinogenesis
    119241117 (PIK3R2)
   05230 Central carbon metabolism in cancer
    119241117 (PIK3R2)
   05231 Choline metabolism in cancer
    119241117 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119241117 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119241117 (PIK3R2)
   05212 Pancreatic cancer
    119241117 (PIK3R2)
   05225 Hepatocellular carcinoma
    119241117 (PIK3R2)
   05226 Gastric cancer
    119241117 (PIK3R2)
   05214 Glioma
    119241117 (PIK3R2)
   05221 Acute myeloid leukemia
    119241117 (PIK3R2)
   05220 Chronic myeloid leukemia
    119241117 (PIK3R2)
   05218 Melanoma
    119241117 (PIK3R2)
   05211 Renal cell carcinoma
    119241117 (PIK3R2)
   05215 Prostate cancer
    119241117 (PIK3R2)
   05213 Endometrial cancer
    119241117 (PIK3R2)
   05224 Breast cancer
    119241117 (PIK3R2)
   05222 Small cell lung cancer
    119241117 (PIK3R2)
   05223 Non-small cell lung cancer
    119241117 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119241117 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    119241117 (PIK3R2)
   05161 Hepatitis B
    119241117 (PIK3R2)
   05160 Hepatitis C
    119241117 (PIK3R2)
   05171 Coronavirus disease
    119241117 (PIK3R2)
   05164 Influenza A
    119241117 (PIK3R2)
   05162 Measles
    119241117 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    119241117 (PIK3R2)
   05163 Human cytomegalovirus infection
    119241117 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119241117 (PIK3R2)
   05169 Epstein-Barr virus infection
    119241117 (PIK3R2)
   05165 Human papillomavirus infection
    119241117 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    119241117 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    119241117 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    119241117 (PIK3R2)
   05142 Chagas disease
    119241117 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119241117 (PIK3R2)
   05017 Spinocerebellar ataxia
    119241117 (PIK3R2)
   05020 Prion disease
    119241117 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119241117 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    119241117 (PIK3R2)
   05415 Diabetic cardiomyopathy
    119241117 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    119241117 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    119241117 (PIK3R2)
   04931 Insulin resistance
    119241117 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    119241117 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119241117 (PIK3R2)
   01524 Platinum drug resistance
    119241117 (PIK3R2)
   01522 Endocrine resistance
    119241117 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tod04131]
    119241117 (PIK3R2)
Membrane trafficking [BR:tod04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    119241117 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 SH3_9 ODF2_C Ribosomal_L22e ATG11
Other DBs
NCBI-GeneID: 119241117
NCBI-ProteinID: XP_037362058
Position
Unknown
AA seq 724 aa
MAGSEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVSEGSERCPQNVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLILPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSEFLYRPELPAARTDWTLSDLEQLDMAALSDCVKSFLLA
LPTPLLTPEAVAEAHRVLRESSGPVGPALEPPTLTLHHALTLRFLLQHLGRVARRSPSPN
LALRALGTTFGPLLLQAPPPAAGGAPDGTEPSPDFPVLLVEKLLQEHLEEQEVAPPALPP
KPPKAKPAPQVLTNGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGE
YTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLLYP
VSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAF
NETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQ
ELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQ
YALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGD
TKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPP
PATR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atggctggctctgagggcttccagtaccgtgcgctctacccattccgccgggagcggcca
gaggacctggagctgctgccaggtgatgtgctggtggtgagccgggcagccttgcaggca
ctgggggtatctgagggcagtgagcgctgcccacagaacgtgggctggatgcccggtctc
aatgagcgcacacggcagcgaggcgacttccctggcacctacgtcgagttcctggggcct
gtagctctggccaggcctggccctcgtccccgtggcccccgcccactgcctgctaggccc
cgagatgggccccccgagccaggcctcatactccctgacctgcctgaacagttctcccca
cctgacgtggcaccccccctcttagtgaagcttgtggaggccattgagcggacaggactg
gacagcgaattcctgtacagaccggagctgcctgccgcacgcacagattggaccctgagt
gatctcgagcagttggacatggcagccctatcagactgcgtcaaaagcttcctgctggca
cttcccacacccctcctgacacctgaggctgtggctgaggctcaccgggtcctccgggag
tcctcagggccagtggggccagcactggagcccccaacgctgaccctgcaccatgccctc
acgctgcgcttcctgcttcagcacctgggccgggtggccagacgatccccatccccaaac
ctggccctgcgagccctgggcaccaccttcgggccactgctgctgcaggccccaccacca
gcagcagggggcgcgccagatgggactgagcctagccccgacttccctgtgttgctggtg
gagaagttgcttcaggaacatctggaggaacaagaggtcgcacccccagcactgccgcct
aaaccccctaaggcaaagccagccccccaagtcctcaccaatgggggaagcccaccctcc
ctgcaggatgccgagtggtactggggtgacatctccagggaggaggtaaatgagaaactc
cgggacacacctgatggcaccttcctggtccgagatgcatccagcaagatccagggggag
tacacgctgaccctcaggaaaggtgggaataacaagctgatcaaggtcttccaccgagat
gggcactatggcttctcagagcctctcaccttctgctctgtggtggacctcatcacccac
taccgccatgagtcgctggcccagtacaacgccaaactggacacgcggctgctgtacccc
gtgtccaagtaccagcaggaccagatcgtcaaggaggacagtgtggaggcagtgggcgcc
cagctcaaagtctaccaccagcagtaccaggacaagagccgcgagtatgaccagctctac
gaggaatacacacgcacctcccaagaactgcagatgaagcgcacagcaatcgaggccttt
aatgagaccatcaagatctttgaagagcagggtcagacacaagagaagtgcagcaaggag
tatctggaacgctttcggcgtgagggcaatgagaaagagatgcagaggatcctgctgaac
tctgagcggctcaagtcccgcattgctgagatccacgagagccgcacaaaactggagcag
gagctgcgggcacaggcctcagacaaccgggagatcgacaagcgcatgaacagcctcaag
ccagacctcatgcagctgcgcaagatccgagatcagtacctcgtgtggctcacccagaaa
ggtgcccgacagaagaaaatcaatgagtggttgggaatcaaaaacgagactgaagaccag
tatgcactgatggaggatgaggatgatcttccccaccacgaggagcgcacgtggtatgtg
ggcaagatcaaccgcacccaggctgaggaaatgctgagtgggaagcgggacggcaccttc
ctcatccgtgagagcagccagcggggctgctatgcctgctctgtggtggtggacggtgac
accaaacactgcgtcatctaccgcacagccacgggctttggcttcgcagagccctacaac
ctgtacgggtcgctgaaggagctggtgctgcactaccagcacgcctcgctggtgcagcac
aacgacgccctcaccgtgacgcttgcccatccagtgcgcgcccctggccccgggccccca
cccgccacccgctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (9)   
   Pfam (9)   
All databases (15)   

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