KEGG   Ursus americanus (American black bear): 123799710
Entry
123799710         CDS       T07931                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar00562  Inositol phosphate metabolism
uar01100  Metabolic pathways
uar04015  Rap1 signaling pathway
uar04020  Calcium signaling pathway
uar04022  cGMP-PKG signaling pathway
uar04062  Chemokine signaling pathway
uar04070  Phosphatidylinositol signaling system
uar04071  Sphingolipid signaling pathway
uar04072  Phospholipase D signaling pathway
uar04081  Hormone signaling
uar04082  Neuroactive ligand signaling
uar04261  Adrenergic signaling in cardiomyocytes
uar04270  Vascular smooth muscle contraction
uar04310  Wnt signaling pathway
uar04371  Apelin signaling pathway
uar04540  Gap junction
uar04611  Platelet activation
uar04613  Neutrophil extracellular trap formation
uar04621  NOD-like receptor signaling pathway
uar04713  Circadian entrainment
uar04720  Long-term potentiation
uar04723  Retrograde endocannabinoid signaling
uar04724  Glutamatergic synapse
uar04725  Cholinergic synapse
uar04726  Serotonergic synapse
uar04728  Dopaminergic synapse
uar04730  Long-term depression
uar04742  Taste transduction
uar04750  Inflammatory mediator regulation of TRP channels
uar04911  Insulin secretion
uar04912  GnRH signaling pathway
uar04915  Estrogen signaling pathway
uar04916  Melanogenesis
uar04918  Thyroid hormone synthesis
uar04919  Thyroid hormone signaling pathway
uar04921  Oxytocin signaling pathway
uar04922  Glucagon signaling pathway
uar04924  Renin secretion
uar04925  Aldosterone synthesis and secretion
uar04926  Relaxin signaling pathway
uar04927  Cortisol synthesis and secretion
uar04928  Parathyroid hormone synthesis, secretion and action
uar04929  GnRH secretion
uar04933  AGE-RAGE signaling pathway in diabetic complications
uar04934  Cushing syndrome
uar04935  Growth hormone synthesis, secretion and action
uar04961  Endocrine and other factor-regulated calcium reabsorption
uar04970  Salivary secretion
uar04971  Gastric acid secretion
uar04972  Pancreatic secretion
uar04973  Carbohydrate digestion and absorption
uar05010  Alzheimer disease
uar05016  Huntington disease
uar05017  Spinocerebellar ataxia
uar05022  Pathways of neurodegeneration - multiple diseases
uar05142  Chagas disease
uar05143  African trypanosomiasis
uar05146  Amoebiasis
uar05163  Human cytomegalovirus infection
uar05200  Pathways in cancer
uar05415  Diabetic cardiomyopathy
uar05417  Lipid and atherosclerosis
Module
uar_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:uar00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123799710 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    123799710 (PLCB1)
   04310 Wnt signaling pathway
    123799710 (PLCB1)
   04371 Apelin signaling pathway
    123799710 (PLCB1)
   04020 Calcium signaling pathway
    123799710 (PLCB1)
   04070 Phosphatidylinositol signaling system
    123799710 (PLCB1)
   04072 Phospholipase D signaling pathway
    123799710 (PLCB1)
   04071 Sphingolipid signaling pathway
    123799710 (PLCB1)
   04022 cGMP-PKG signaling pathway
    123799710 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    123799710 (PLCB1)
   04081 Hormone signaling
    123799710 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    123799710 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123799710 (PLCB1)
   04613 Neutrophil extracellular trap formation
    123799710 (PLCB1)
   04621 NOD-like receptor signaling pathway
    123799710 (PLCB1)
   04062 Chemokine signaling pathway
    123799710 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    123799710 (PLCB1)
   04922 Glucagon signaling pathway
    123799710 (PLCB1)
   04929 GnRH secretion
    123799710 (PLCB1)
   04912 GnRH signaling pathway
    123799710 (PLCB1)
   04915 Estrogen signaling pathway
    123799710 (PLCB1)
   04921 Oxytocin signaling pathway
    123799710 (PLCB1)
   04926 Relaxin signaling pathway
    123799710 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    123799710 (PLCB1)
   04918 Thyroid hormone synthesis
    123799710 (PLCB1)
   04919 Thyroid hormone signaling pathway
    123799710 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    123799710 (PLCB1)
   04916 Melanogenesis
    123799710 (PLCB1)
   04924 Renin secretion
    123799710 (PLCB1)
   04925 Aldosterone synthesis and secretion
    123799710 (PLCB1)
   04927 Cortisol synthesis and secretion
    123799710 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    123799710 (PLCB1)
   04270 Vascular smooth muscle contraction
    123799710 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    123799710 (PLCB1)
   04971 Gastric acid secretion
    123799710 (PLCB1)
   04972 Pancreatic secretion
    123799710 (PLCB1)
   04973 Carbohydrate digestion and absorption
    123799710 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    123799710 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    123799710 (PLCB1)
   04725 Cholinergic synapse
    123799710 (PLCB1)
   04728 Dopaminergic synapse
    123799710 (PLCB1)
   04726 Serotonergic synapse
    123799710 (PLCB1)
   04720 Long-term potentiation
    123799710 (PLCB1)
   04730 Long-term depression
    123799710 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    123799710 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    123799710 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    123799710 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    123799710 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123799710 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    123799710 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    123799710 (PLCB1)
   05142 Chagas disease
    123799710 (PLCB1)
   05143 African trypanosomiasis
    123799710 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123799710 (PLCB1)
   05016 Huntington disease
    123799710 (PLCB1)
   05017 Spinocerebellar ataxia
    123799710 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    123799710 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123799710 (PLCB1)
   05415 Diabetic cardiomyopathy
    123799710 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    123799710 (PLCB1)
   04934 Cushing syndrome
    123799710 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:uar04131]
    123799710 (PLCB1)
Enzymes [BR:uar01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     123799710 (PLCB1)
Membrane trafficking [BR:uar04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    123799710 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    123799710 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 123799710
NCBI-ProteinID: XP_045664838
Position
Unknown
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSAIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIDELKQQKSFVKLQKKHYKEMKDLVKRHHRKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQTDLEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSLASEPGKMNHKPPSS
EELEGDNPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcagcccggagtgcacgctttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactctgctattgtcactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaataaggag
acggagctgttagatctcagccttgtcaaggatgcgagatgtgggaagcatgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacattgggcacctggagcat
cgcatgataacagtggtgtatgggcctgacttggttaacatctcccacttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtcaagagatgcatttctggaaaaagcctatactaagcttaag
ctgcaagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaacgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctgaacaatctttgc
cctcgacctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccatacctt
accgtcgatcagatgatggactttatcaatcttaagcagagagatccccggctaaatgaa
atactttatccacctttaaagcaagaacaagtccaagtattgattgagaagtatgagccc
aacaatagcctcgccaaaaaaggacagatatcagtggatggctttatgcgctatctaagt
ggagaagaaaatggagtcgtttcgcctgagaaactggatttgaatgaagatatgtctcag
cccctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctggaaactcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagttggactgctggaagggacggactgctgaagaggaaccagtcatcacccatgggttc
accatgacaactgaaatatccttcaaggaagtgatagaagcaatcgctgagtgtgcattt
aagacatcaccttttccaattctgctttcatttgagaaccacgtagattctccaaagcag
caagccaagatggcggagtattgccgactgatctttggagatgctcttctcatggaacca
ctggaaaaatacccactggaatctggagttcctcttccaagtcctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcgcacaagtcatcagaaggaagtggcaaaaag
aagctctcggaacaagcctccaacacgtacagtgactcctccagcgtgtttgaaccctcg
tctccaggagccggggaagctgataccgagagtgatgatgatgatgatgatgatgactgt
aaaaaatcttcaatggatgaggggactgccgggagtgaggccatggccaccgaagagatg
tctaacctggtgaactatattcagccagtcaagtttgagtcatttgaaatttcaaaaaag
agaaatagaagttttgaaatgtcttccttcgtggaaaccaaaggtctcgagcagctgacg
aaatcgccagtggaatttgtagaatacaacaaaatgcagcttagcaggatatatccaaaa
ggaacccgtgtggattcatctaactacatgcctcagctcttctggaatgcgggttgccaa
atggttgcacttaattttcaaactgtggacctggctatgcaaataaatatggggatgtac
gaatacaatgggaaaagtggctacagattaaagccagagttcatgaggagacctgacaag
cattttgatccattcaccgaaggcatcgtggatgggatagtggccaacactttatctgtc
aagattatttcaggtcagtttctttctgataagaaagttgggacttacgtggaagtggat
atgtttggtttgcctgtggacacgaggaggaaggcatttaagaccaaaacatcacaagga
aatgctgtaaatcctgtctgggaagaggagcccattgtgttcaaaaaggtggttcttcct
tcgctggcctgtttgaggatagcagtttatgaagaagggggtaaatttattggtcaccgg
atcttgccagtacaggcgattcggccaggctatcactacatctgtctgaggaatgagagg
aaccagcctctgacgctcccagctgtctttgtctacatagaggtgaaagactatgtccca
gatacatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatg
gagcaaagagctaaacagttggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggccgatcctggggaaacaccgtcagaagctccaagtgaagccaggacaacgccagca
gaaaatggagtgaatcacactacgtccctggcacccaaaccaccttcccaggctctccac
agccaaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtggaagcccagaccatcgacgagctaaagcagcagaaatcgtttgtg
aaacttcaaaagaaacactacaaagaaatgaaagacctggttaaaagacaccacaggaaa
accactgaccttatcaaggagcacactacaaaatataatgaaattcagaatgattacttg
aggaggagggcagctttggagaagacagccaaaaaggacagtaagaaaaaatcagatcct
agcagtcctgaccatggttcgtcaacgattgagcaagatcttgctgccctagatgccgaa
atgacccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcga
caagagcagtattacagtgaaaaataccagaagcgagagcatattaaactgcttattcaa
aagttgacggatgttgctgaagaatgtcagaacaatcagctgaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaagatggacaaaaaaaggcaggagaagata
acagaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccgg
tcatacatccaggaggtggtgcagtacatcaagaggttagaagaggcccaaagtaaacgg
caagaaaaacttgtagagaaacacaaggagatacgtcagcagatcctggacgaaaagccc
aagctgcagacggacctggagcaagagtaccaagacaagttcaaaagactgcccctggag
atcctggagttcgtgcaggaagccatgaaagggaagatcagcgaagacagcaatcacagt
tctgcgcctccctccctggcctcagagcctggaaaaatgaaccacaagcctccctccagt
gaggagctagaaggagacaacccaggaaaagagttcgatactcctctgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (6)   
   Pfam (6)   
All databases (16)   

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