KEGG   Ursus maritimus (polar bear): 103674425
Entry
103674425         CDS       T03271                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr00562  Inositol phosphate metabolism
umr01100  Metabolic pathways
umr04015  Rap1 signaling pathway
umr04020  Calcium signaling pathway
umr04022  cGMP-PKG signaling pathway
umr04062  Chemokine signaling pathway
umr04070  Phosphatidylinositol signaling system
umr04071  Sphingolipid signaling pathway
umr04072  Phospholipase D signaling pathway
umr04081  Hormone signaling
umr04082  Neuroactive ligand signaling
umr04261  Adrenergic signaling in cardiomyocytes
umr04270  Vascular smooth muscle contraction
umr04310  Wnt signaling pathway
umr04371  Apelin signaling pathway
umr04540  Gap junction
umr04611  Platelet activation
umr04613  Neutrophil extracellular trap formation
umr04621  NOD-like receptor signaling pathway
umr04713  Circadian entrainment
umr04720  Long-term potentiation
umr04723  Retrograde endocannabinoid signaling
umr04724  Glutamatergic synapse
umr04725  Cholinergic synapse
umr04726  Serotonergic synapse
umr04728  Dopaminergic synapse
umr04730  Long-term depression
umr04742  Taste transduction
umr04750  Inflammatory mediator regulation of TRP channels
umr04911  Insulin secretion
umr04912  GnRH signaling pathway
umr04915  Estrogen signaling pathway
umr04916  Melanogenesis
umr04918  Thyroid hormone synthesis
umr04919  Thyroid hormone signaling pathway
umr04921  Oxytocin signaling pathway
umr04922  Glucagon signaling pathway
umr04924  Renin secretion
umr04925  Aldosterone synthesis and secretion
umr04926  Relaxin signaling pathway
umr04927  Cortisol synthesis and secretion
umr04928  Parathyroid hormone synthesis, secretion and action
umr04929  GnRH secretion
umr04933  AGE-RAGE signaling pathway in diabetic complications
umr04934  Cushing syndrome
umr04935  Growth hormone synthesis, secretion and action
umr04961  Endocrine and other factor-regulated calcium reabsorption
umr04970  Salivary secretion
umr04971  Gastric acid secretion
umr04972  Pancreatic secretion
umr04973  Carbohydrate digestion and absorption
umr05010  Alzheimer disease
umr05016  Huntington disease
umr05017  Spinocerebellar ataxia
umr05022  Pathways of neurodegeneration - multiple diseases
umr05142  Chagas disease
umr05143  African trypanosomiasis
umr05146  Amoebiasis
umr05163  Human cytomegalovirus infection
umr05200  Pathways in cancer
umr05415  Diabetic cardiomyopathy
umr05417  Lipid and atherosclerosis
Module
umr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:umr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103674425 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    103674425 (PLCB1)
   04310 Wnt signaling pathway
    103674425 (PLCB1)
   04371 Apelin signaling pathway
    103674425 (PLCB1)
   04020 Calcium signaling pathway
    103674425 (PLCB1)
   04070 Phosphatidylinositol signaling system
    103674425 (PLCB1)
   04072 Phospholipase D signaling pathway
    103674425 (PLCB1)
   04071 Sphingolipid signaling pathway
    103674425 (PLCB1)
   04022 cGMP-PKG signaling pathway
    103674425 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    103674425 (PLCB1)
   04081 Hormone signaling
    103674425 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    103674425 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103674425 (PLCB1)
   04613 Neutrophil extracellular trap formation
    103674425 (PLCB1)
   04621 NOD-like receptor signaling pathway
    103674425 (PLCB1)
   04062 Chemokine signaling pathway
    103674425 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    103674425 (PLCB1)
   04922 Glucagon signaling pathway
    103674425 (PLCB1)
   04929 GnRH secretion
    103674425 (PLCB1)
   04912 GnRH signaling pathway
    103674425 (PLCB1)
   04915 Estrogen signaling pathway
    103674425 (PLCB1)
   04921 Oxytocin signaling pathway
    103674425 (PLCB1)
   04926 Relaxin signaling pathway
    103674425 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    103674425 (PLCB1)
   04918 Thyroid hormone synthesis
    103674425 (PLCB1)
   04919 Thyroid hormone signaling pathway
    103674425 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    103674425 (PLCB1)
   04916 Melanogenesis
    103674425 (PLCB1)
   04924 Renin secretion
    103674425 (PLCB1)
   04925 Aldosterone synthesis and secretion
    103674425 (PLCB1)
   04927 Cortisol synthesis and secretion
    103674425 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    103674425 (PLCB1)
   04270 Vascular smooth muscle contraction
    103674425 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    103674425 (PLCB1)
   04971 Gastric acid secretion
    103674425 (PLCB1)
   04972 Pancreatic secretion
    103674425 (PLCB1)
   04973 Carbohydrate digestion and absorption
    103674425 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    103674425 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    103674425 (PLCB1)
   04725 Cholinergic synapse
    103674425 (PLCB1)
   04728 Dopaminergic synapse
    103674425 (PLCB1)
   04726 Serotonergic synapse
    103674425 (PLCB1)
   04720 Long-term potentiation
    103674425 (PLCB1)
   04730 Long-term depression
    103674425 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    103674425 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    103674425 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    103674425 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    103674425 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103674425 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    103674425 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103674425 (PLCB1)
   05142 Chagas disease
    103674425 (PLCB1)
   05143 African trypanosomiasis
    103674425 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103674425 (PLCB1)
   05016 Huntington disease
    103674425 (PLCB1)
   05017 Spinocerebellar ataxia
    103674425 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    103674425 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103674425 (PLCB1)
   05415 Diabetic cardiomyopathy
    103674425 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103674425 (PLCB1)
   04934 Cushing syndrome
    103674425 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:umr04131]
    103674425 (PLCB1)
Enzymes [BR:umr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     103674425 (PLCB1)
Membrane trafficking [BR:umr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    103674425 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    103674425 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 103674425
NCBI-ProteinID: XP_040493918
UniProt: A0A8M1GQN0
Position
Unknown
AA seq 1173 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSAIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIDELKQQKSFVKLQKKHYKEMKDLVKRHHRKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQMKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KGDGSSSFLSETCHEDPSVSPNFTPPNPQALKW
NT seq 3522 nt   +upstreamnt  +downstreamnt
atggccggggctcagcccggagtgcacgctttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactctgctattgtcactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaataaggag
acggagctgttagatctcagccttgtcaaggatgcgagatgtgggaagcatgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacattgggcacctggagcat
cgcatgataacagtggtgtatgggcctgacttggttaacatctcccacttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtcaagagatgcatttctggaaaaagcctatactaagcttaag
ctgcaagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaacgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctgaacaatctttgc
cctcgacctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccatacctt
accgtcgatcagatgatggactttatcaatcttaagcagagagatccccggctaaatgaa
atactttatccacctttaaagcaagaacaagtccaagtattgattgagaagtatgagccc
aacaatagcctcgccaaaaaaggacagatatcagtggatggctttatgcgctatctaagt
ggagaagaaaatggagtcgtttcgcctgagaaactggatttgaatgaagatatgtctcag
cccctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctggaaactcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagttggactgctggaagggacggactgctgaagaggaaccagtcatcacccatgggttc
accatgacaactgaaatatccttcaaggaagtgatagaagcaatcgctgagtgtgcattt
aagacatcaccttttccaattctgctttcatttgagaaccacgtagattctccaaagcag
caagccaagatggcggagtattgccgactgatctttggagatgctcttctcatggaacca
ctggaaaaatacccactggaatctggagttcctcttccaagtcctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcgcacaagtcatcagaaggaagtggcaaaaag
aagctctcggaacaagcctccaacacgtacagtgactcctccagcgtgtttgaaccctcg
tctccaggagccggggaagctgataccgagagtgatgatgatgatgatgatgatgactgt
aaaaaatcttcaatggatgaggggactgctgggagtgaggccatggccaccgaagagatg
tctaacctggtgaactatattcagccagtcaagtttgagtcatttgaaatttcaaaaaag
agaaatagaagttttgaaatgtcttccttcgtggaaaccaaaggtctcgagcagctgacg
aaatcgccagtggaatttgtagaatacaacaaaatgcagcttagcaggatatatccaaaa
ggaacccgtgtggattcatctaactacatgcctcagctcttctggaatgcgggttgccaa
atggttgcacttaattttcaaactgtggacctggctatgcagataaatatggggatgtac
gaatacaatgggaaaagtggctacagattaaagccagagttcatgaggagacctgacaag
cattttgatccattcaccgaaggcatcgtggatgggatagtggccaacactttatctgtc
aagattatttcaggtcagtttctttctgataagaaagttgggacttacgtggaagtggat
atgtttggtttgcctgtggacacgaggaggaaggcgtttaagaccaaaacatcacaagga
aatgctgtaaatcctgtctgggaagaggagcccattgtgttcaaaaaggtggttcttcct
tcgctggcctgtttgaggatagcagtttatgaagaagggggtaaatttatcggtcaccgg
atcttgccagtacaggcgattcggccaggctatcactacatctgtctgaggaatgagagg
aaccagcctctgacgctcccagctgtctttgtctacatagaggtgaaagactatgtccca
gatacatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatg
gagcaaagagctaaacagttggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggccgatcctggggaaacaccgtcagaagctccaagtgaagccaggacaacgccagca
gaaaatggagtgaatcacactacgtccctggcacccaaaccaccttcccaggctctccac
agccaaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtggaagcccagaccatcgacgagctaaagcagcagaaatcgtttgtg
aaacttcaaaagaaacactacaaagaaatgaaagacctggttaaaagacaccacaggaaa
accactgaccttatcaaggagcacactacaaaatataatgaaattcagaatgattacttg
aggaggagggcagctttggagaagacagccaaaaaggacagtaagaaaaaatcagatcct
agcagtcctgaccatggttcgtcaacgattgagcaagatcttgctgccctagatgccgaa
atgacccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcga
caagagcagtattacagtgaaaaataccagaagcgagagcatattaaactgcttattcaa
aagttgacggatgttgctgaagaatgtcagaacaatcagatgaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaagatggacaaaaaaaggcaggagaagata
acagaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccgg
tcatacatccaggaggtggtgcagtacatcaagaggttagaagaggcccaaagtaaacgg
caagaaaaacttgtagagaaacacaaggagatacgtcagcagatcctggacgaaaagccc
aagggggacggttcctcctcattcttgtcggaaacttgccatgaggatccctctgtttcc
cccaactttactccccccaaccctcaagctctcaagtggtga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (8)   
   RefSeq(nuc) (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (6)   
   Pfam (6)   
All databases (22)   

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