ID A0A016U0T8_9BILA Unreviewed; 327 AA.
AC A0A016U0T8;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 05-FEB-2025, entry version 30.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EYC08715.1};
GN Name=Acey_s0064.g3494 {ECO:0000313|EMBL:EYC08715.1};
GN Synonyms=Acey-Y48C3A.3 {ECO:0000313|EMBL:EYC08715.1};
GN ORFNames=Y032_0064g3494 {ECO:0000313|EMBL:EYC08715.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC08715.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the FAX family. {ECO:0000256|ARBA:ARBA00006475}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC08715.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JARK01001400; EYC08715.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016U0T8; -.
DR OrthoDB; 5809458at2759; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd03193; GST_C_Metaxin; 1.
DR CDD; cd03080; GST_N_Metaxin_like; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR InterPro; IPR026928; FAX/IsoI-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR050931; Mito_Protein_Transport_Metaxin.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12289:SF41; FAILED AXON CONNECTIONS-RELATED; 1.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF17172; GST_N_4; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01200; SUF1.1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..158
FT /note="Thioredoxin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17172"
FT DOMAIN 219..281
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
SQ SEQUENCE 327 AA; 37861 MW; B37C0A776D569F7E CRC64;
MTSLEDLTKQ LQDLPNWGKA AVAGGLAIIL YIPYRWLTTA PRKSPIKEDW KSGVVYLYQF
PRTRILPSPS APCLKVETWL RMAEIQYENI PCLLSPRSKE GTLPFVEFEG VEYPDSSFII
RDLTRLLGVK LEDHLNDEQR ALSRAFEEMA HNSLLASHRL FRLENVSKFT ELLPQEHFGF
FYPILIYLFQ RKYVSTGASM LTWSGIGKHS REEQINIGSD DIRAISKYLG TKHYFTGFKP
TRIDATLFAV LAQIVYAPYD NEHLDVIKNE CPNIMEYVER IKNRYWPDWG EATTKYSMDS
NWKKRPKGYT SLNNSLNDTL PKKKSTD
//
