ID A0A059DW54_9PROT Unreviewed; 686 AA.
AC A0A059DW54;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 18-JUN-2025, entry version 42.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00044770};
DE EC=2.4.99.28 {ECO:0000256|ARBA:ARBA00044770};
GN ORFNames=HY17_02430 {ECO:0000313|EMBL:KCZ49984.1};
OS Hyphomonas sp. CY54-11-8.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Hyphomonadales; Hyphomonadaceae; Hyphomonas.
OX NCBI_TaxID=1280944 {ECO:0000313|EMBL:KCZ49984.1, ECO:0000313|Proteomes:UP000024460};
RN [1] {ECO:0000313|EMBL:KCZ49984.1, ECO:0000313|Proteomes:UP000024460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CY54-11-8 {ECO:0000313|EMBL:KCZ49984.1,
RC ECO:0000313|Proteomes:UP000024460};
RA Lai Q., Shao Z.;
RT "Hyphomonas sp. CY54-11-8 Genome Sequencing.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.99.28;
CC Evidence={ECO:0000256|ARBA:ARBA00049902};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the transpeptidase
CC family. {ECO:0000256|ARBA:ARBA00007090}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 51 family. {ECO:0000256|ARBA:ARBA00007739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KCZ49984.1}.
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DR EMBL; AWFD01000001; KCZ49984.1; -; Genomic_DNA.
DR RefSeq; WP_034761779.1; NZ_AWFD01000001.1.
DR AlphaFoldDB; A0A059DW54; -.
DR STRING; 1280944.HY17_02430; -.
DR PATRIC; fig|1280944.3.peg.483; -.
DR eggNOG; COG4953; Bacteria.
DR OrthoDB; 9766909at2; -.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000024460; Unassembled WGS sequence.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:TreeGrafter.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR050396; Glycosyltr_51/Transpeptidase.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000024460};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 45..220
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 296..539
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 597..679
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 686 AA; 74288 MW; 6029743BEB649D03 CRC64;
MLTARRIFVG VFALFLAVVI ADRLLPPPLE RAGGLSALVT DRDGKPLRAF ATPDGRWRFA
GDLDRIDPDF IDALIRVEDK RFYQHRGTDW MGLSRAALDS VFAGRIVSGG STLTMQTARM
LEPRDRNIGS KLIEIARAWQ LERRLTKDEI LSLYLSLTPY GGNLEGVRAA SWSYFGHEAD
KLSKDEIALL IALPQSPEVR RPDRHPENAE RARNWVAEKL QRYDVFTKGD VEDVATLSVP
GRRRDFPDRA WHGTAKALAE GPREDVRSTL DAGLQAEVER IALTRAEAEG EDVQVSVLVV
HVPTRAVRAV AGSASRDRPG GWLDLTAQAR SPGSTLKPFI YAMAFDDGTA APDTRVADLP
TRFASYQPEN FDRMFRGDVR VSDALQHSLN IPAVAMLDRV GPERFAAQLA SAGARPRISG
GAEHEAGLAI ALGGAGLTAR ELAVLYAALG DDGVAKPLVW RADEEAANYE ATGKRLVSGE
SAGEVLDILR KAPTPEGRMP GSLTAHAPQI AFKTGTSYGF RDAWAAGVSG QHAIIVWVGR
ADGAPRAGKT GHDTALPILF EVADRVAQHL QDEGEATMRL TSQKRLLKSH GAMKSLEDAG
PPQILFPPQA AELWAGPVNG RAARGFVLAG RGEGRLSWYI DGRPCDTDDA GAPVWKPERP
GFYTVTAVDS AGRASRVRVR VLTGPA
//
