ID A0A068U4D3_COFCA Unreviewed; 661 AA.
AC A0A068U4D3;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 28-JAN-2026, entry version 48.
DE RecName: Full=Disease resistance protein RGA3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSCOC_T00015146001 {ECO:0000313|EMBL:CDP03415.1};
OS Coffea canephora (Robusta coffee).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Gentianales; Rubiaceae; Ixoroideae; Gardenieae complex;
OC Bertiereae - Coffeeae clade; Coffeeae; Coffea.
OX NCBI_TaxID=49390 {ECO:0000313|EMBL:CDP03415.1, ECO:0000313|Proteomes:UP000295252};
RN [1] {ECO:0000313|Proteomes:UP000295252}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DH200-94 {ECO:0000313|Proteomes:UP000295252};
RX PubMed=25190796; DOI=10.1126/science.1255274;
RA Denoeud F., Carretero-Paulet L., Dereeper A., Droc G., Guyot R.,
RA Pietrella M., Zheng C., Alberti A., Anthony F., Aprea G., Aury J.M.,
RA Bento P., Bernard M., Bocs S., Campa C., Cenci A., Combes M.C.,
RA Crouzillat D., Da Silva C., Daddiego L., De Bellis F., Dussert S.,
RA Garsmeur O., Gayraud T., Guignon V., Jahn K., Jamilloux V., Joet T.,
RA Labadie K., Lan T., Leclercq J., Lepelley M., Leroy T., Li L.T.,
RA Librado P., Lopez L., Munoz A., Noel B., Pallavicini A., Perrotta G.,
RA Poncet V., Pot D., Priyono X., Rigoreau M., Rouard M., Rozas J.,
RA Tranchant-Dubreuil C., VanBuren R., Zhang Q., Andrade A.C., Argout X.,
RA Bertrand B., de Kochko A., Graziosi G., Henry R.J., Jayarama X., Ming R.,
RA Nagai C., Rounsley S., Sankoff D., Giuliano G., Albert V.A., Wincker P.,
RA Lashermes P.;
RT "The coffee genome provides insight into the convergent evolution of
RT caffeine biosynthesis.";
RL Science 345:1181-1184(2014).
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; HG739094; CDP03415.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068U4D3; -.
DR Gramene; CDP03415; CDP03415; GSCOC_T00015146001.
DR InParanoid; A0A068U4D3; -.
DR PhylomeDB; A0A068U4D3; -.
DR Proteomes; UP000295252; Chromosome V.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-ARBA.
DR FunFam; 3.40.50.300:FF:001091; Probable disease resistance protein At1g61300; 1.
DR FunFam; 1.10.10.10:FF:000322; Probable disease resistance protein At1g63360; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR056789; LRR_R13L1-DRL21.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR058922; WHD_DRP.
DR PANTHER; PTHR36766:SF70; DISEASE RESISTANCE PROTEIN RGA4; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF25019; LRR_R13L1-DRL21; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR Pfam; PF23559; WHD_DRP; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000295252};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..103
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 144..316
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 402..475
FT /note="Disease resistance protein winged helix"
FT /evidence="ECO:0000259|Pfam:PF23559"
FT DOMAIN 555..616
FT /note="R13L1/DRL21-like LRR repeat region"
FT /evidence="ECO:0000259|Pfam:PF25019"
SQ SEQUENCE 661 AA; 75256 MW; 635F21A9E163A10B CRC64;
MAGALVDALL GSTTEVLVEK AINLASEQIG QFVGFKKDLE KLKDTLIGIQ AFLRDAEKEQ
VTKEFVKRWL ENLERVAFDA GNLLDDVNYE MIRRKVEIQN QMKRKVCLFF SLSNPIAFRL
EKNRKTTSLF VDQTFVGRDG DVLEIVGRLT APSNNENISV QPIVGMGGIG KTTLARQVFN
DPKIVNHFAK RIWVCVSDDF DVDRLFDFML ESLGGQKPGG GVRQLEAKVQ DLKNLLDDKK
FLLVLDDVWD KESTRWNWNE FLGSLRGTSQ AMGSWILVTT REQQVVDITR ISSPQGYSLK
QLSDDQCWHI LKENAFCGGE VPDGLQDIGL KIAQRCRGLP LAASVLGGML RNKEPDEWQS
LESGFQSLGG DENVDVTNTI LKLSFDHLPH PSLKKCFAYC SIFPKDFQME RNELIQLWAA
EGFLHSNPRN DMHMEEVGNR YFTILLDSNL FQDAEKDDYG NVLNCKMHDL VHDMVQSISN
SKTLRLTESG SVLMETSSIR YLALERSEKE MTFSSTESFK QLHSFLDLFD ALPPPHPYFP
FLSWLLLYGW PHWESLPEQL QHLSALTTLA LSDFGVKSLP DWFGKLSSLE ELELSNCRKL
ENLPSHQSMR SLTRLRKLWI THCPLLKERC DPESSSTDPN SERSKISHIP TIVIDWENIR
G
//
