ID A0A074ZF07_AURSE Unreviewed; 1277 AA.
AC A0A074ZF07;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 28-JAN-2026, entry version 51.
DE RecName: Full=Antiviral helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AUEXF2481DRAFT_37741 {ECO:0000313|EMBL:KEQ97211.1};
OS Aureobasidium subglaciale (strain EXF-2481) (Aureobasidium pullulans var.
OS subglaciale).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043005 {ECO:0000313|EMBL:KEQ97211.1, ECO:0000313|Proteomes:UP000030641};
RN [1] {ECO:0000313|EMBL:KEQ97211.1, ECO:0000313|Proteomes:UP000030641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-2481 {ECO:0000313|EMBL:KEQ97211.1,
RC ECO:0000313|Proteomes:UP000030641};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
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DR EMBL; KL584754; KEQ97211.1; -; Genomic_DNA.
DR RefSeq; XP_013345851.1; XM_013490397.1.
DR AlphaFoldDB; A0A074ZF07; -.
DR FunCoup; A0A074ZF07; 921.
DR STRING; 1043005.A0A074ZF07; -.
DR GeneID; 25365924; -.
DR HOGENOM; CLU_002902_1_4_1; -.
DR InParanoid; A0A074ZF07; -.
DR OMA; DHVNIIM; -.
DR OrthoDB; 64767at2759; -.
DR Proteomes; UP000030641; Unassembled WGS sequence.
DR GO; GO:0055087; C:Ski complex; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IEA:TreeGrafter.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR FunFam; 3.40.50.300:FF:000354; ATP-dependent RNA helicase SKI2; 1.
DR FunFam; 3.40.50.300:FF:000987; DEAD/DEAH box RNA helicase; 1.
DR FunFam; 1.10.3380.30:FF:000001; Ski2 ATP-dependent RNA helicase; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.30.30.1160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR025696; Beta-barrel_MTR4.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR050699; RNA-DNA_Helicase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF1; ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030641};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 315..471
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 600..801
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 526..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..546
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..582
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1277 AA; 142840 MW; 6D190A5880F9A9F1 CRC64;
MDDLTPALER LRLADAPAGG IDAILDQQRP RKRTRRSPDK IRSSLEKDFL APSTSFSTPW
LDRLQQRWDC PTNYEELFEL APTQTRTIIR FTREGLEGRV TGYKEVTVPA NSATAKNSTS
ILRKPANRAD FVRGAAGFFP FAPGGLDAVE ATAAAEDQLL LGAQTNGTVK QSGLDKVINF
GADGALLELP PGFTRGLDLQ KKAPTDEATA QEVENVLEEE PQDPVAANGD VADEVKLADE
DEDEGEEEEL DALLPVEFPA LAARGQLGLS SNKRTGHEWA HMVDVNRPMT NFRDLVPEMA
REWPFEPDTF QKEAIYHLEN GDSVFVAAHT SAGKTVVAEY AIALAAKHMT KAIYTSPIKA
LSNQKFRDFR QEFDDVGILT GDVQIRPEAS CLIMTTEILR SMLYRGADII RDVEFVIFDE
VHYVNDLERG VVWEEVIIML PEHVTLILLS ATVPNTLEFA SWVGRTKKKN IYVISTPKRP
VPLEHYLWAG KEMYKIVNSD KQFIEKGWKD ANDVLSGKDK IKAAEEKQEA AAAAARGGGS
QRGGRGQSQR GGPQRGGAQR GGAQQRGRGA PAQRAQGNIA RTGRGGGRTT AAQDRNIWVH
LIQHLRKEDL LPACIFVFSK KRCEENAEAL SNLDYCTATE KSAIHMILEK SLARLKPEDR
QLPQIRRLRE LLSRGIAVHH GGMLPIVKEC VEILFAKTLV KVLFATETFA MGLNLPTRTV
VFSGYRKHDG RQFRDLLPGE YTQMAGRAGR RGLDPVGSVI IVAPGADEAP PAGRLRQMML
GDPTKLRSQF RLTYNMILNL LRVEALKIEE MIKRSFSENA TQALLPEHEQ KVKLSEADLA
KIKREQCDIC DKDLEACHTA AMRYQQLTAD LHLALLGSPI GRRMLHPKRL VVYKRDGIRT
VGVLLREGVS KGISPSLSVM EVVPSKSKRQ DADLLPYLPR YRRRFTPQPA DAEHLKLRLA
TVPYSELECL TASTLQFDVT GASSKMPEAM EQLKEQLLGA CSSWTSATWN EADYSRIKEI
GIRNIIDERN KAAYDAQEGK ESILCENLDR HFAMMHDEWL IKENINQLRA LMSDQNLQLL
PDYEQRIAVL KDLGFVDENS RVELKGKVAC EIHSADELVL TELVLENVLA DYEPEEIVAL
LSAFVFQEKT DQIPTMTPAL ERGQETIIKI SEKVNHYQTL HQVILSADDS NDFVSRPRFG
LVEVIYEWAR GMSFNRITDL TDVMEGTIVR VITRLDETCR EVKNAARIIG DPTLFTKMQT
CQEMIKRDIC ATASLYM
//
