ID A0A075R8B3_BRELA Unreviewed; 529 AA.
AC A0A075R8B3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 18-JUN-2025, entry version 44.
DE RecName: Full=ATP-dependent RNA helicase CshA {ECO:0000256|ARBA:ARBA00067932};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=cshA_3 {ECO:0000313|EMBL:AIG27528.1};
GN ORFNames=BRLA_c032160 {ECO:0000313|EMBL:AIG27528.1};
OS Brevibacillus laterosporus LMG 15441.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
OC Brevibacillus.
OX NCBI_TaxID=1042163 {ECO:0000313|EMBL:AIG27528.1, ECO:0000313|Proteomes:UP000005850};
RN [1] {ECO:0000313|EMBL:AIG27528.1, ECO:0000313|Proteomes:UP000005850}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 15441 {ECO:0000313|EMBL:AIG27528.1,
RC ECO:0000313|Proteomes:UP000005850};
RX PubMed=21914864; DOI=10.1128/JB.05696-11;
RA Djukic M., Poehlein A., Thurmer A., Daniel R.;
RT "Genome sequence of Brevibacillus laterosporus LMG 15441, a pathogen of
RT invertebrates.";
RL J. Bacteriol. 193:5535-5536(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00047984};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family.
CC {ECO:0000256|ARBA:ARBA00038437, ECO:0000256|RuleBase:RU000492}.
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DR EMBL; CP007806; AIG27528.1; -; Genomic_DNA.
DR RefSeq; WP_003337006.1; NZ_CP007806.1.
DR AlphaFoldDB; A0A075R8B3; -.
DR STRING; 1042163.BRLA_c032160; -.
DR KEGG; blr:BRLA_c032160; -.
DR eggNOG; COG0513; Bacteria.
DR HOGENOM; CLU_003041_21_0_9; -.
DR Proteomes; UP000005850; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005840; C:ribosome; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0033592; F:RNA strand annealing activity; IEA:TreeGrafter.
DR GO; GO:0009409; P:response to cold; IEA:TreeGrafter.
DR CDD; cd00268; DEADc; 1.
DR CDD; cd12252; RRM_DbpA; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR FunFam; 3.40.50.300:FF:000108; ATP-dependent RNA helicase RhlE; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR005580; DbpA/CsdA_RNA-bd_dom.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR050547; DEAD_box_RNA_helicases.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47963; DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL; 1.
DR PANTHER; PTHR47963:SF5; DEAD-BOX ATP-DEPENDENT RNA HELICASE CSHA; 1.
DR Pfam; PF03880; DbpA; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF25399; DeaD_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000492};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU000492};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000492};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000492};
KW Reference proteome {ECO:0000313|Proteomes:UP000005850}.
FT DOMAIN 2..30
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 33..203
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 214..375
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT MOTIF 2..30
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
SQ SEQUENCE 529 AA; 59302 MW; 75914F3AAEF20AC2 CRC64;
MTIFSDLALH KNVLQAIHDM GFEEPSPIQA ACIPKILEGG DLIGQAQTGT GKTAAFGIPL
AEVLNPTNNR IQAIVLTPTR ELAIQVAGEL VRICKYKKIR TLPIYGGQSI SHQIRALRQG
VHVVIGTPGR VLDHLRRKTL HLENVKMLVL DEADEMLDMG FIEDIETILS HMKAERQTLL
FSATMPPEIK RLAHRYMKNP ETVAVSREEV TAPSIEQVYY KVFERNKRES LCRILDSQDV
ELGIIFCRTK RGVDELSEAL QARGYMADGL HGDLSQAQRD KVMKAFREGT IEFLIATDVA
ARGIDVGNVS HVINYDIPQD PESYVHRIGR TGRAGRKGIA MTLVTPREMR QLMVIQKQTK
ASLITRTVPT LEEIAERKRT QLREQLRSLI ESESVNGMYQ EIVNELMQEH DPAKVAAAAL
HLAFHTDPSG NDEEEGYNFG ETGAARGMVR FFLNVGRNVN MKPQDLVREI SESVGIPGKS
VGRIDIFENF TFVEVPEDVA PFVYEALRQT RINGKRINLE PAKPRTRKS
//
