ID A0A085U8N1_YERRU Unreviewed; 621 AA.
AC A0A085U8N1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 28-JAN-2026, entry version 65.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:SUQ00722.1};
GN ORFNames=CSF007_0415 {ECO:0000313|EMBL:CEK25878.1}, NCTC10476_02027
GN {ECO:0000313|EMBL:SUQ00722.1};
OS Yersinia ruckeri.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Enterobacterales; Yersiniaceae; Yersinia.
OX NCBI_TaxID=29486 {ECO:0000313|EMBL:CEK25878.1};
RN [1] {ECO:0000313|EMBL:CEK25878.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CSF007-82 {ECO:0000313|EMBL:CEK25878.1};
RA Nelson M.C., LaPatra S.E., Welch T.J., Graf J.;
RT "Complete Genome Sequence of Yersinia ruckeri Strain CSF007-82, Etiologic
RT Agent of Red Mouth Disease in Salmonid Fish.";
RL Genome Announc. 3:1-2(2015).
RN [2] {ECO:0000313|EMBL:SUQ00722.1, ECO:0000313|Proteomes:UP000255169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10476 {ECO:0000313|EMBL:SUQ00722.1,
RC ECO:0000313|Proteomes:UP000255169};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; LN681231; CEK25878.1; -; Genomic_DNA.
DR EMBL; UHJG01000001; SUQ00722.1; -; Genomic_DNA.
DR RefSeq; WP_038242138.1; NZ_CABIHT010000057.1.
DR AlphaFoldDB; A0A085U8N1; -.
DR STRING; 29486.UGYR_10560; -.
DR GeneID; 66877862; -.
DR PATRIC; fig|29486.44.peg.1067; -.
DR eggNOG; COG3276; Bacteria.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000255169; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0035368; F:selenocysteine insertion sequence binding; IEA:TreeGrafter.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:TreeGrafter.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR GO; GO:0016259; P:selenocysteine metabolic process; IEA:TreeGrafter.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR FunFam; 1.10.10.10:FF:000350; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 2.40.30.10:FF:000080; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR050543; eIF2G.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048649; WHD_1st_3rd_SelB.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF21458; WHD_1st_3rd_SelB; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:CEK25878.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000255169}.
FT DOMAIN 1..171
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 621 AA; 68885 MW; 3F3F1F037AE0EDDF CRC64;
MIIATAGHVD HGKTTLLQAI TGINADRLPE EKQRGMTIDL GYAYWPQPDG SSLGFIDVPG
HEKFLANMLA GMGGIDHALL VVACDDGVMA QTHEHLTILR LSGRPKLTVA LTKADRADEQ
QIAQVRQQVL AELVQQGWVA EQVSLFVTAA NSGTGIDELR THLAQLNRQQ SDAQRIQRRF
RLAIDRAFSL KGSGLVVTGT VLAGQVAVGE TLWLTGSDCP VRVRGIHAQN QSATQAQAGQ
RIALNITGDT SKQQISRGDW LLAQRPPETQ DRVLVEVTTD TPMHHWQSLH LHQGASHITG
RVSMLNGTET PMLAELLLDT PLYLAENDRF ILRDIGAKQT LGGARVIALT SPKRGKRQPA
FLAWLTALAQ ASSDIEIFNL HLTKGPLSIQ QFAWARQLSD KQVSELLADS HHLVAGDSVL
STEMAESVSQ SLRQVLSGYH QQHSDQLGLG RARLRRMALP TLDEGLVYRV IDELLACGQL
THTRGWLHLP EHRLAFTPEE EKEWLRARGY FGSDPWWVRD LAVAIEMDEE QMRGLLRKAA
RLGHITAIVA DRYYLNDLIY QFADLIRTLD TEKGSASAAD FRDHLGIGRK LAIQILEFFD
RSGFTRRLGN DHILRDRGMF S
//
