ID   A0A087VKW4_BALRE        Unreviewed;       529 AA.
AC   A0A087VKW4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-NOV-2024, entry version 40.
DE   SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:KFO13256.1};
GN   ORFNames=N312_11915 {ECO:0000313|EMBL:KFO13256.1};
OS   Balearica regulorum gibbericeps (East African grey crowned-crane).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Neoaves; Gruiformes; Gruidae; Balearica.
OX   NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO13256.1, ECO:0000313|Proteomes:UP000053309};
RN   [1] {ECO:0000313|EMBL:KFO13256.1, ECO:0000313|Proteomes:UP000053309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO13256.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KL497097; KFO13256.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087VKW4; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000053309; Unassembled WGS sequence.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03739; SOCS_SOCS5; 1.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR037343; SOCS5_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          374..469
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          464..513
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
SQ   SEQUENCE   529 AA;  60584 MW;  55C7083A29C6B456 CRC64;
     MDKVGKMWNN FKYRCQNLFS HEGGSQNENV VVTSNSCASA KEKAIQITDL AQQQPNSPLR
     ENIALQLGLS PSKNPARRNQ NCVTEIPQIV EISIEKENDS CVTTGARLAR RDSYSRHAPC
     CSTKTQSSLD TEKRFGRTRS GLQRRERRYG VSSVHDMDAV SNRTVGSRSL RQRLQDTVGL
     CFPMRTYSKQ SKPLFSNKRK IHLSELMLEK CPFPAGSDLA QKWHLIKQHT APVSPHSTFF
     DTFDPSLVST EDEEDRLRER RRLSIEEGVD PPPNAQIHTF EATAQVNPLY KLGPKLAPGM
     TELTGDKNIT PPGNCDSEED TTTLCLQSRR QKQRQMSGES HGHISRQGAW KVHTQIDYIH
     CLVPDLLQIT GNPCYWGVMD RYEAEALLEG KPEGTFLLRD SAQEDYLFSV SFRRYNRSLH
     ARIEQWNHNF SFDAHDPCVF HSSTVTGLLE HYKDPSSCMF FEPLLTVSLN RTFPFSLQYI
     CRAVICRCTT YDGIDDLPLP SMLQDFLKEY HYKQKVRVRW LEREPIKTK
//