ID A0A089Q526_9ENTR Unreviewed; 612 AA.
AC A0A089Q526;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 28-JAN-2026, entry version 47.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=JT31_13280 {ECO:0000313|EMBL:AIR05549.1};
OS Cedecea neteri.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Enterobacterales; Enterobacteriaceae; Cedecea.
OX NCBI_TaxID=158822 {ECO:0000313|EMBL:AIR05549.1, ECO:0000313|Proteomes:UP000029481};
RN [1] {ECO:0000313|EMBL:AIR05549.1, ECO:0000313|Proteomes:UP000029481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSMD04 {ECO:0000313|EMBL:AIR05549.1,
RC ECO:0000313|Proteomes:UP000029481};
RA Tan J.-Y.;
RT "Cedecea neteri SSMD04 Genome Sequencing.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP009451; AIR05549.1; -; Genomic_DNA.
DR RefSeq; WP_038477712.1; NZ_CP009451.1.
DR AlphaFoldDB; A0A089Q526; -.
DR KEGG; cnt:JT31_13280; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000029481; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0035368; F:selenocysteine insertion sequence binding; IEA:TreeGrafter.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:TreeGrafter.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR GO; GO:0016259; P:selenocysteine metabolic process; IEA:TreeGrafter.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR FunFam; 1.10.10.10:FF:000350; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 2.40.30.10:FF:000080; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR050543; eIF2G.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048649; WHD_1st_3rd_SelB.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF21458; WHD_1st_3rd_SelB; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000029481}.
FT DOMAIN 1..166
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 612 AA; 67303 MW; 133533A2CCB94E89 CRC64;
MIIATAGHVD HGKTTLLQAL TGVNADRLPE EKKRGMTIDL GYAYWPQPDG RVIGFIDVPG
HEKFLANMLA GVGGIDHALL VIACDDGVMA QTREHLAILQ LTGNPQVTVA LTKADRVSDS
RIAEVRDEVA ALLGDTLAAI FVTAATSGEG VEALQQHLIG LSERPHATSH RFRLAIDRAF
TVKGAGLVVT GTALSGEVNV GDSLWLTGAD KPMRVRGLHA QNQPVSSAMA GQRIALNISG
DAEKNDISRG DWLLSEKPLQ PIERVIVELQ TLQPLQQWQP LHIHHSARHV TGRVSLLEGN
LAELVLDVPL WLADNDRLVL RDISARTTLA GARAVLLNAP RRGKRQPAFL SWLADLAKGA
DDPQALEAHL ARGAVLLSEF SWARQLTAEG LQALLDQPGY LQAGNALLSP DVAALWQQKL
LDVLARYHQQ HDDQPGPGRE RLRRMALPAE DEGLVLSLIE RMRAEGLLIS RQGWLHLPGH
EPGFSATQQA VWDKVDARLG DEPWWVRDLA KETGEEEQAM RQLLRSAAQQ GLVTAILKDR
YYRNDRLQAF ADLIRELDQT HGATNAADFR DRLGVGRKLA IQILEYFDKT GFTRRRGNDH
LLRDKALFTP SR
//
