ID A0A090V8T5_PSEVU Unreviewed; 617 AA.
AC A0A090V8T5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 28-JAN-2026, entry version 47.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:GAL59694.1};
GN ORFNames=EV102420_22_00150 {ECO:0000313|EMBL:GAL59694.1};
OS Pseudescherichia vulneris NBRC 102420.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Enterobacterales; Enterobacteriaceae; Pseudescherichia.
OX NCBI_TaxID=1115515 {ECO:0000313|EMBL:GAL59694.1, ECO:0000313|Proteomes:UP000029462};
RN [1] {ECO:0000313|EMBL:GAL59694.1, ECO:0000313|Proteomes:UP000029462}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 102420 {ECO:0000313|EMBL:GAL59694.1,
RC ECO:0000313|Proteomes:UP000029462};
RA Yoshida Y., Hosoyama A., Tsuchikane K., Ohji S., Ichikawa N., Kimura A.,
RA Yamazoe A., Ezaki T., Fujita N.;
RT "Whole genome shotgun sequence of Escherichia vulneris NBRC 102420.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAL59694.1}.
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DR EMBL; BBMZ01000022; GAL59694.1; -; Genomic_DNA.
DR RefSeq; WP_042393949.1; NZ_BBMZ01000022.1.
DR AlphaFoldDB; A0A090V8T5; -.
DR STRING; 1115515.EV102420_22_00150; -.
DR eggNOG; COG3276; Bacteria.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000029462; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0035368; F:selenocysteine insertion sequence binding; IEA:TreeGrafter.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:TreeGrafter.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR GO; GO:0016259; P:selenocysteine metabolic process; IEA:TreeGrafter.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR FunFam; 1.10.10.10:FF:000350; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 2.40.30.10:FF:000080; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR050543; eIF2G.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048649; WHD_1st_3rd_SelB.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF21458; WHD_1st_3rd_SelB; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:GAL59694.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000029462}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 617 AA; 67790 MW; AB697FE7E466E053 CRC64;
MIIATAGHVD HGKTTLLEAL TGINADRLPE EKKRGMTIDL GYAYWPQPDG RVPGFIDVPG
HEKFLANMLA GVGGIDGALL VVACDDGVMA QTREHLAILQ LTGNPALTVA LTKADRVDEA
RIAEVEAEVR SVLAEYGYPQ ATLFTTAATQ GMGIEALRAH LLALPEREQT DERRFRLAID
RAFSVKGAGL VVTGTALSGS VKVGDTLWLT GVNRPMRVRG LHAQNQPVEQ AHAGQRIALN
IAGDAEKEAI SRGDWLLAEA PPEPVTRLIV ALHTHAPLGQ WQPLHIHHAA SHVTGRVSLL
EDNLAELVLD TPLWLADNDR LVLRDIAART TLAGARVVTL NPPRRGKRKP EYLAWIAALT
EASDDAGALA VHLTRGAVHL PSFAWERQLN AQGLAALTES PALIQAGDSL ISAAVAARWQ
RKILDTLATY HAQHRDEPGP GRERLRRMAL PMENEALVLT LIERMRESGD IHSHHGWLHL
PDHKAGFTAE QDTIWQKVAM LFADEPWWVR DLAREVGADE QIMRSVLHQA AQQGLITAIV
KDRYYRNDRI VAFANLIRAL DGERGSTCAA DFRDQLNVGR KLAIQILEYF DRIGFTRRRG
NDHLLRDALL FPANPQA
//
