ID A0A091FUE1_CORBR Unreviewed; 161 AA.
AC A0A091FUE1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-OCT-2025, entry version 46.
DE RecName: Full=Transcription factor HES-5 {ECO:0000256|ARBA:ARBA00072975};
DE AltName: Full=Hairy and enhancer of split 5 {ECO:0000256|ARBA:ARBA00081413};
GN ORFNames=N302_14301 {ECO:0000313|EMBL:KFO64845.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Corvoidea; Corvidae; Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO64845.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO64845.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO64845.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor of genes that require a bHLH
CC protein for their transcription. Plays an important role as
CC neurogenesis negative regulator. {ECO:0000256|ARBA:ARBA00060201}.
CC -!- SUBUNIT: Transcription repression requires formation of a complex with
CC a corepressor protein of the Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00023791}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KK719670; KFO64845.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091FUE1; -.
DR STRING; 85066.A0A091FUE1; -.
DR KEGG; cbrc:103622271; -.
DR OrthoDB; 6085656at2759; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProtKB-ARBA.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:UniProtKB-ARBA.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:UniProtKB-ARBA.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11461; bHLH-O_HES5; 1.
DR FunFam; 4.10.280.10:FF:000033; Transcription factor HES-5; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR050370; HES_HEY.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 19..75
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 94..126
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 125..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 161 AA; 18660 MW; F99E824FA75FE64C CRC64;
MAPSTVFLEP DNLLTPKEKN KLRKPVVEKM RRDRINSSIE QLKLLLEKEF QRHQPNSKLE
KADILEMTVS YLKQQSQLQM KTAGSFHKSS QFDFREGYSR CLQEAFHFLS LHKVRTETQT
KLLSHFQKSQ SSAPEVSFSP GNTGALKQVS PKDSSPLWRP W
//
