ID   A0A091KCC9_9AVES        Unreviewed;       530 AA.
AC   A0A091KCC9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-NOV-2024, entry version 41.
DE   SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:KFP38189.1};
GN   ORFNames=N324_11980 {ECO:0000313|EMBL:KFP38189.1};
OS   Chlamydotis macqueenii (Macqueen's bustard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Neoaves; Otidimorphae; Otidiformes;
OC   Otididae; Chlamydotis.
OX   NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP38189.1, ECO:0000313|Proteomes:UP000053330};
RN   [1] {ECO:0000313|EMBL:KFP38189.1, ECO:0000313|Proteomes:UP000053330}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP38189.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   EMBL; KK739296; KFP38189.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091KCC9; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000053330; Unassembled WGS sequence.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03739; SOCS_SOCS5; 1.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR037343; SOCS5_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053330};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          375..470
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          465..514
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
SQ   SEQUENCE   530 AA;  60768 MW;  4C31DFB8BBDE3DC8 CRC64;
     MDKVGKMWNN FKYRCQNLFS HEGGSQNENV VVNSNSCSST KEKAVQITDL AQQQPSSPLR
     ENIALQLGLS PSKNSARRNQ NCVTEIPQIV EISIEKENDS CVTTGARLAR RDSYSRHAPW
     ACSTKTQSSL DTEKRFGRTR SSLQRRERRY GVSSVHDMDA VSNRTVGSRS LRQRLQDTVG
     LCFPMRTYSK QSKPLFSNKR KIHLSELMLE KCPFPAGSDL AQKWHLIKQH TAPVSPHSTF
     FDTFDPSLVS TEDEEDRLRE RRRLSIEEGV DPPPNAQIHT FEATAQVNPL YKLGPKLAPG
     MTELTGDKNI TPPGSCDSEE DTTTLCLQSR RQKQRQMSGE SHGHISRQGA WKVHTQIDYI
     HCLVPDLLQI TGNPCYWGVM DRYEAEALLE GKPEGTFLLR DSAQEDYLFS VSFRRYNRSL
     HARIEQWNHN FSFDAHDPCV FHSSTVTGLL EHYKDPSSCM FFEPLLTVSL NRTFPFSLQY
     ICRAVICRCT TYDGIDDLPL PSMLQDFLKE YHYKQKVRVR WLEREPMKTK
//