ID A0A091RCQ7_MERNU Unreviewed; 373 AA.
AC A0A091RCQ7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE RecName: Full=Peroxisomal membrane protein PEX13 {ECO:0000256|ARBA:ARBA00034535};
DE AltName: Full=Peroxin-13 {ECO:0000256|ARBA:ARBA00029693};
DE Flags: Fragment;
GN ORFNames=N331_10184 {ECO:0000313|EMBL:KFQ26447.1};
OS Merops nubicus (Northern carmine bee-eater).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Coraciimorphae;
OC Coraciiformes; Meropidae; Merops.
OX NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ26447.1, ECO:0000313|Proteomes:UP000052967};
RN [1] {ECO:0000313|EMBL:KFQ26447.1, ECO:0000313|Proteomes:UP000052967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ26447.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the PEX13-PEX14 docking complex, a translocon
CC channel that specifically mediates the import of peroxisomal cargo
CC proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms
CC a large import pore which can be opened to a diameter of about 9 nm.
CC Mechanistically, PEX5 receptor along with cargo proteins associates
CC with the PEX14 subunit of the PEX13-PEX14 docking complex in the
CC cytosol, leading to the insertion of the receptor into the organelle
CC membrane with the concomitant translocation of the cargo into the
CC peroxisome matrix. Involved in the import of PTS1- and PTS2-type
CC containing proteins. {ECO:0000256|ARBA:ARBA00056165}.
CC -!- SUBUNIT: Interacts (via SH3 domain) with PEX14 (via SH3-binding motif);
CC forming the PEX13-PEX14 docking complex. Interacts with PEX19.
CC {ECO:0000256|ARBA:ARBA00063917}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC {ECO:0000256|ARBA:ARBA00004585}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004585}.
CC -!- SIMILARITY: Belongs to the peroxin-13 family.
CC {ECO:0000256|ARBA:ARBA00006033}.
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DR EMBL; KK699664; KFQ26447.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091RCQ7; -.
DR Proteomes; UP000052967; Unassembled WGS sequence.
DR GO; GO:1990429; C:peroxisomal importomer complex; IEA:TreeGrafter.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016560; P:protein import into peroxisome matrix, docking; IEA:InterPro.
DR CDD; cd11864; SH3_PEX13_eumet; 1.
DR FunFam; 2.30.30.40:FF:000109; Peroxisomal biogenesis factor 13; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR007223; Peroxin-13_N.
DR InterPro; IPR035463; Pex13.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR19332; PEROXISOMAL MEMBRANE PROTEIN PEX13; 1.
DR PANTHER; PTHR19332:SF1; PEROXISOMAL MEMBRANE PROTEIN PEX13; 1.
DR Pfam; PF04088; Peroxin-13_N; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000052967};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 243..307
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ26447.1"
FT NON_TER 373
FT /evidence="ECO:0000313|EMBL:KFQ26447.1"
SQ SEQUENCE 373 AA; 41419 MW; 9B9C9F36FCE2D0EF CRC64;
RSADFGDNLL TRPAQPAVVR IPPPVLPRPS QQTRSSNLST FRPAYTSSFS PAYGSYGTSF
YGGYSPYSYG YGSLGYNRFR TDDIPPSRFV QQAEESSRGA FQSIESIVHA FASVSMMMDA
TFSAVYNSFR AVLDVANHFS RLKVHFTKVF SAFALVRTIR YLYQRLQRLL GLRKSSENED
LWAESEGTVA RIGLDDRAAT SAKSWPIFLF FAVILGGPYL IWKLLSTYSN EETVSSNWAS
GEDDHVVGRA EYDFSALSEE EISFRAGDML KLAPKEQQPK IRGWLLASYD GQTTGLVPAN
YIKILGKKKG RRTVDLQRIR EHRPARTSKS VGGSAATVTL EEQEAAFESA FAESNKVPVV
PNSTVVSGEK QEL
//
