ID A0A091SGI5_PELCR Unreviewed; 102 AA.
AC A0A091SGI5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 05-FEB-2025, entry version 32.
DE RecName: Full=Somatoliberin {ECO:0000256|ARBA:ARBA00040782};
DE AltName: Full=Growth hormone-releasing factor {ECO:0000256|ARBA:ARBA00042164};
DE AltName: Full=Growth hormone-releasing hormone {ECO:0000256|ARBA:ARBA00041953};
DE Flags: Fragment;
GN ORFNames=N334_11852 {ECO:0000313|EMBL:KFQ57130.1};
OS Pelecanus crispus (Dalmatian pelican).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Aequornithes; Pelecaniformes;
OC Pelecanidae; Pelecanus.
OX NCBI_TaxID=36300 {ECO:0000313|EMBL:KFQ57130.1, ECO:0000313|Proteomes:UP000054150};
RN [1] {ECO:0000313|EMBL:KFQ57130.1, ECO:0000313|Proteomes:UP000054150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N334 {ECO:0000313|EMBL:KFQ57130.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC adenohypophyse to stimulate the secretion of growth hormone.
CC {ECO:0000256|ARBA:ARBA00037623}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR EMBL; KK470191; KFQ57130.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091SGI5; -.
DR Proteomes; UP000054150; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0043204; C:perikaryon; IEA:TreeGrafter.
DR GO; GO:0043195; C:terminal bouton; IEA:TreeGrafter.
DR GO; GO:0016608; F:growth hormone-releasing hormone activity; IEA:TreeGrafter.
DR GO; GO:0031770; F:growth hormone-releasing hormone receptor binding; IEA:TreeGrafter.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0051428; F:peptide hormone receptor binding; IEA:TreeGrafter.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0030252; P:growth hormone secretion; IEA:TreeGrafter.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0032880; P:regulation of protein localization; IEA:TreeGrafter.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR046963; VIP/GHRH-like.
DR PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1.
DR PANTHER; PTHR11213:SF6; SOMATOLIBERIN; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Neuropeptide {ECO:0000313|EMBL:KFQ57130.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054150};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 5..27
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFQ57130.1"
FT NON_TER 102
FT /evidence="ECO:0000313|EMBL:KFQ57130.1"
SQ SEQUENCE 102 AA; 11701 MW; CE703CA761318819 CRC64;
RMQRHADAIF TDNYRKFLGQ ISARKFLQTI IGKRLGSSEN SPGEGVHQFL TRRQSDSILM
DSRYHQQMVL RDFLGAILQN QRPQDINSSG LEGFPSTLAK FM
//
