ID A0A091W2N3_OPIHO Unreviewed; 148 AA.
AC A0A091W2N3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 05-FEB-2025, entry version 31.
DE RecName: Full=Gastric inhibitory polypeptide {ECO:0000256|ARBA:ARBA00013490};
DE AltName: Full=Glucose-dependent insulinotropic polypeptide {ECO:0000256|ARBA:ARBA00031537};
DE Flags: Fragment;
GN ORFNames=N306_12482 {ECO:0000313|EMBL:KFR09882.1};
OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Opisthocomiformes;
OC Opisthocomidae; Opisthocomus.
OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR09882.1, ECO:0000313|Proteomes:UP000053605};
RN [1] {ECO:0000313|EMBL:KFR09882.1, ECO:0000313|Proteomes:UP000053605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR09882.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potent stimulator of insulin secretion and relatively poor
CC inhibitor of gastric acid secretion. {ECO:0000256|ARBA:ARBA00002766}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR EMBL; KK734620; KFR09882.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091W2N3; -.
DR STRING; 30419.A0A091W2N3; -.
DR PhylomeDB; A0A091W2N3; -.
DR Proteomes; UP000053605; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0031769; F:glucagon receptor binding; IEA:TreeGrafter.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0042304; P:regulation of fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0050796; P:regulation of insulin secretion; IEA:InterPro.
DR GO; GO:0009749; P:response to glucose; IEA:InterPro.
DR GO; GO:0042594; P:response to starvation; IEA:TreeGrafter.
DR Gene3D; 6.10.250.590; -; 1.
DR InterPro; IPR039078; GIP.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR15211:SF0; GASTRIC INHIBITORY POLYPEPTIDE; 1.
DR PANTHER; PTHR15211; GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000053605};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..148
FT /note="Gastric inhibitory polypeptide"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001880977"
FT DOMAIN 40..66
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|SMART:SM00070"
FT NON_TER 148
FT /evidence="ECO:0000313|EMBL:KFR09882.1"
SQ SEQUENCE 148 AA; 16878 MW; A7829221E64F6AF0 CRC64;
MMSFKVLSLL LASLGFVLME ENVSGVSIRT PSARPVQRRY SEATLASDYS RAMDNMLKRN
FVEWLLARRE KKSDNTIEHY KREAEPQVAV ANGQRLDLGT QEAKDFSAWL LKAKKNQSFT
SLEGSEGLKD VLNQEFLTWL MSTDLCRP
//
