ID A0A093BXE0_TAUER Unreviewed; 207 AA.
AC A0A093BXE0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE RecName: Full=Metaxin-2 {ECO:0000256|ARBA:ARBA00072180};
DE AltName: Full=Mitochondrial outer membrane import complex protein 2 {ECO:0000256|ARBA:ARBA00076977};
DE Flags: Fragment;
GN ORFNames=N340_11055 {ECO:0000313|EMBL:KFV04637.1};
OS Tauraco erythrolophus (Red-crested turaco).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Otidimorphae; Musophagiformes;
OC Musophagidae; Tauraco.
OX NCBI_TaxID=121530 {ECO:0000313|EMBL:KFV04637.1, ECO:0000313|Proteomes:UP000053661};
RN [1] {ECO:0000313|EMBL:KFV04637.1, ECO:0000313|Proteomes:UP000053661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N340 {ECO:0000313|EMBL:KFV04637.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC {ECO:0000256|ARBA:ARBA00058396}.
CC -!- SUBUNIT: Interacts with MTX1/metaxin-1. Associates with the
CC mitochondrial contact site and cristae organizing system (MICOS)
CC complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19,
CC CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13.
CC This complex was also known under the names MINOS or MitOS complex. The
CC MICOS complex associates with mitochondrial outer membrane proteins
CC SAMM50, MTX1 and MTX2 (together described as components of the
CC mitochondrial outer membrane sorting assembly machinery (SAM) complex)
CC and DNAJC11, mitochondrial inner membrane protein TMEM11 and with
CC HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a
CC large protein complex spanning both membranes termed the mitochondrial
CC intermembrane space bridging (MIB) complex.
CC {ECO:0000256|ARBA:ARBA00063864}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004294}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|ARBA:ARBA00009170}.
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DR EMBL; KL449686; KFV04637.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093BXE0; -.
DR Proteomes; UP000053661; Unassembled WGS sequence.
DR GO; GO:0001401; C:SAM complex; IEA:InterPro.
DR GO; GO:0007005; P:mitochondrion organization; IEA:TreeGrafter.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd03211; GST_C_Metaxin2; 1.
DR FunFam; 1.20.1050.10:FF:000033; metaxin-2 isoform X1; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR050931; Mito_Protein_Transport_Metaxin.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF38; METAXIN-2; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000053661};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..92
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 118..180
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV04637.1"
FT NON_TER 207
FT /evidence="ECO:0000313|EMBL:KFV04637.1"
SQ SEQUENCE 207 AA; 23658 MW; FB5AE38EDD1229CF CRC64;
GKVPFIHVGN QVVSELGPIV QFVKAKGHSL SDGLDEVQKA EMKAYMELVN NMLLTAELYL
QWCDDVTVEE ITHPRYGSPY PWPLNRILSY QKQWEVRRKM KAIGWGGKTL EQVLEDVDQC
CQALSQRLGT QPYFFNKQPT ELDALVFGHL FTILTTQLTT DELSEKVKNY SNLTAFCRRI
EQQYFEGHDK DGSATVAARS AKRSLLR
//
