ID   A0A093L2G6_FULGA        Unreviewed;       530 AA.
AC   A0A093L2G6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   08-OCT-2025, entry version 46.
DE   SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:KFW03606.1};
GN   ORFNames=N327_06994 {ECO:0000313|EMBL:KFW03606.1};
OS   Fulmarus glacialis (Northern fulmar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Neoaves; Aequornithes; Procellariiformes;
OC   Procellariidae; Fulmarus.
OX   NCBI_TaxID=30455 {ECO:0000313|EMBL:KFW03606.1, ECO:0000313|Proteomes:UP000053806};
RN   [1] {ECO:0000313|EMBL:KFW03606.1, ECO:0000313|Proteomes:UP000053806}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N327 {ECO:0000313|EMBL:KFW03606.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   EMBL; KK596534; KFW03606.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093L2G6; -.
DR   KEGG; fga:104075709; -.
DR   OrthoDB; 8820570at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000053806; Unassembled WGS sequence.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03739; SOCS_SOCS5; 1.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR037343; SOCS5_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053806};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          375..470
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          465..514
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
SQ   SEQUENCE   530 AA;  60665 MW;  000AB6325DCF9FD0 CRC64;
     MDKVGKMWNN FKYRCQNLFS HEGGSQNENV VVNSNSCSST KEKAIQITGL AQQQPSSPLR
     ENIALQLGLS PSKNSARRNQ NCVTEIPQIV EISIEKENDS CVTTGARLAR RDSYSRHAPC
     SCSTKTQSSL DTEKRFGRTR SGLQRRERRY GVSSVHDMDA VSNRTVGSRS LRQRLQDTVG
     LCFPMRTYSK QSKPLFSNKR KIHLSELMLE KCPFPAGSDL AQKWHLIKQH TAPVSPHSTF
     FDTFDPSLVS TEDEEDRLRE RRRLSIEEGV DPPPNAQIHT FEATAQVNPL YKLGPKLAPG
     MTELTGDKNI TPPGNCDSEE DTTTLCLQSR RQKQRQMSGE SHSHISRQGA WKVHTQIDYI
     HCLVPDLLQI TGNPCYWGVM DRYEAEALLE GKPEGTFLLR DSAQEDYLFS VSFRRYNRSL
     HARIEQWNHN FSFDAHDPCV FHSSTVTGLL EHYKDPSSCM FFEPLLTVSL NRTFPFSLQY
     ICRAVICRCT TYDGIDDLPL PSMLQDFLKE YHYKQKVRVR WLEREPIKTK
//