ID A0A094IKA5_9BACT Unreviewed; 674 AA.
AC A0A094IKA5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 18-JUN-2025, entry version 41.
DE RecName: Full=Urocanate hydratase {ECO:0000256|NCBIfam:TIGR01228};
DE EC=4.2.1.49 {ECO:0000256|NCBIfam:TIGR01228};
GN Name=hutU {ECO:0000313|EMBL:KFZ27592.1};
GN ORFNames=KQ78_00129 {ECO:0000313|EMBL:KFZ27592.1};
OS Candidatus Izimaplasma bacterium HR2.
OC Bacteria; Bacillati; Mycoplasmatota; Candidatus Izimaplasma.
OX NCBI_TaxID=1541960 {ECO:0000313|EMBL:KFZ27592.1, ECO:0000313|Proteomes:UP000029254};
RN [1] {ECO:0000313|EMBL:KFZ27592.1, ECO:0000313|Proteomes:UP000029254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Skennerton C.T., Haroon M.F., Tyson G.W., Orphan V.J.;
RT "Phylogenomic Analysis of Candidatus Izimaplasma species: Representatives
RT from a Novel Mollicute Clade found in Ocean Sediments.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ27592.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JRFF01000007; KFZ27592.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094IKA5; -.
DR PATRIC; fig|1541960.3.peg.121; -.
DR eggNOG; COG2987; Bacteria.
DR UniPathway; UPA00379; UER00550.
DR Proteomes; UP000029254; Unassembled WGS sequence.
DR GO; GO:0016153; F:urocanate hydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019556; P:L-histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR GO; GO:0019557; P:L-histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.10730; Urocanase like domains; 1.
DR Gene3D; 3.40.1770.10; Urocanase superfamily; 2.
DR InterPro; IPR023637; Urocanase-like.
DR InterPro; IPR035401; Urocanase_C.
DR InterPro; IPR038364; Urocanase_central_sf.
DR InterPro; IPR023636; Urocanase_CS.
DR InterPro; IPR035400; Urocanase_N.
DR InterPro; IPR035085; Urocanase_Rossmann-like.
DR InterPro; IPR036190; Urocanase_sf.
DR NCBIfam; TIGR01228; hutU; 1.
DR NCBIfam; NF003820; PRK05414.1; 1.
DR PANTHER; PTHR12216; UROCANATE HYDRATASE; 1.
DR PANTHER; PTHR12216:SF3; UROCANATE HYDRATASE; 1.
DR Pfam; PF01175; Urocanase; 1.
DR Pfam; PF17392; Urocanase_C; 1.
DR Pfam; PF17391; Urocanase_N; 1.
DR PIRSF; PIRSF001423; Urocanate_hydrat; 1.
DR SUPFAM; SSF111326; Urocanase; 1.
DR PROSITE; PS01233; UROCANASE; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:KFZ27592.1};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000029254}.
FT DOMAIN 85..211
FT /note="Urocanase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17391"
FT DOMAIN 214..437
FT /note="Urocanase Rossmann-like"
FT /evidence="ECO:0000259|Pfam:PF01175"
FT DOMAIN 442..639
FT /note="Urocanase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17392"
SQ SEQUENCE 674 AA; 75415 MW; 294E01BC02CEF483 CRC64;
MNLELTFNIG DIFKELPEYP TFDTGFRRAP KREFNLSKDE TVLALKNALR YIPKEWHDVL
APEFLEELQT LGRIYGFRFR PVGRIYAKGI DEYKGNIVEG KAFQVMIDNN LDFEISLYPY
ELVTYGETGR VMQNWMQYHL VKKYLENLND NQTLVLMSGH PLGLFSAPKN APRVMITNGL
MIGAFNDIDN WNRAAELGVA SYGQMTAGGW MYIGPQGIVH GTYSTLLNAG RSKLGIPEKE
DLKGKLFVTS GLGGMSGAQG KAVEISGGVG IIAEVDKSRI ETRFSQGWVS YVANTPKEAF
DKAEEYMNKL LPLAIAYSGN IVDLLEYAVK ENKHIDLLSD QTSCHAVYSG GYCPASISFE
ERTELLKSDK EKFIKLVDEG LIRHYKAIKA ISSKGTYFFD YGNSFMKAIY DAGVIEICKN
KKNDLDGFIW PSYVEDIMGP ILFDYGYGPF RWVCLSGKDS DLDMTDNAAM EAIDKDRRFQ
DLDNYNWIKD AKKNKLVVGT RARILYQDAY GRLKIALKFN EMVRDGKVGP IMLGRDHHDT
GGTDSPFRET SNIKDGSNVM AEMATHVALG NASRGMSLVA LHNGGGVGIS KALNGGYGLV
LDGSYEKDEI LKTAMLFDVM GGVSRRAWAR NENALSTSKE YNKEDNNSYI TIPYLSDETM
LTKLVNDKYI KGGY
//
