ID A0A096LYJ2_POEFO Unreviewed; 911 AA.
AC A0A096LYJ2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 28-JAN-2026, entry version 49.
DE SubName: Full=Extracellular leucine rich repeat and fibronectin type III domain containing 2 {ECO:0000313|Ensembl:ENSPFOP00000024233.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000024233.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000024233.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSPFOP00000024233.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBUNIT: Interacts with PPP1CA. {ECO:0000256|ARBA:ARBA00065735}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; AYCK01003618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096LYJ2; -.
DR Ensembl; ENSPFOT00000022731.1; ENSPFOP00000024233.1; ENSPFOG00000013891.2.
DR GeneTree; ENSGT00940000159737; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-ARBA.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-ARBA.
DR GO; GO:0045184; P:establishment of protein localization; IEA:UniProtKB-ARBA.
DR GO; GO:0099560; P:synaptic membrane adhesion; IEA:UniProtKB-ARBA.
DR FunFam; 3.80.10.10:FF:000047; protein phosphatase 1 regulatory subunit 29; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR055106; ELFN_Fn3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR050541; LRR_TM_domain-containing.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF204; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 29-RELATED; 1.
DR Pfam; PF22986; Fn3_ELFN; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein phosphatase inhibitor {ECO:0000256|ARBA:ARBA00023272};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 401..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 194..241
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 466..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 911 AA; 98795 MW; DE90E7C5D403D05A CRC64;
TAALYLSSPC SPIPHPSPSA LLLSRPAAVT GDCWLIEGDK GYVWLAICSQ NQPPYETIPQ
HINSTVHDLR LNENKLKAVL FTSMYRFTNL TDLNLTKNEI SYIEDGAFAG QANLQVLQLG
YNKLTNLTEG MLRGLGRMQC LFLQHNLIEI IATNAFWECP NLSSLDLSSN KLARLDPSTF
TSLNRLMVCE LAANPFHCGC ELYSFLTWLE EFNNVTHTYD RLQCETPPEL TGYPLLGQAP
GQGRNARNIL LSACRDGVII PGMTSQMPDP DGSGMGLDNS DPGLYPQPTT ATADPNYVPQ
ISIKLESVSL YTASLLVQIP KPYTKMYILS QYNDTFATEI MSLTKKKEKI PIDKLKPHTN
YTYCVASGSK TQRYNHTCLS FTTRAVGPED LRSNPSTTTH YIMTILGCLF GMVIVLGFVY
YCLRRRRIQE EKEKAISVKK TILEMRYGPE AAAAVANDPG AIQRLQEQTH HHHSGGAGGK
LPPSASSSTG MLHGSANTSS SRLSTLPQVE KMASAFSEAM GSKSNYMDVR TTGMVGESRD
GVLVAGGVGG EVVVDMRGVA ENGTEAGEDS DDDGRGSASE ISTIAKEVDK VNQIINNCID
ALKLDASANI VSTADDGNSL SSSQPPCMAP LSRNLLPLST ASSGDQIMAS SPKPHPPSMA
PVPLVMPLSE RPGISGGGFL SPPYRDPPPA NAVRPLQRQQ SADTTAVKNR CGTPAAVSVK
NARVYSVDIP EQRSDPPKYP TEKGSPAVCG GMGGSGGHGG VGGCGNGKGN LNGGGQQHHL
EVQPDYHSSE HRHSFPALYY EDGNESPLPA QKASFLKPLG RTKREATATY SQLSPARHHN
YNSGYSSSPE YSSESTLRIW ERFRPYKKNP REEASYIAAG HALRKKVQFA KDEDLHDILD
YWKGVSAQQK L
//
