ID A0A0A2K1R9_PENEN Unreviewed; 613 AA.
AC A0A0A2K1R9;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 05-FEB-2025, entry version 35.
DE SubName: Full=Na dependent nucleoside transporter {ECO:0000313|EMBL:KGO50219.1};
GN ORFNames=PEX2_027840 {ECO:0000313|EMBL:KGO50219.1};
OS Penicillium expansum (Blue mold rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=27334 {ECO:0000313|EMBL:KGO50219.1, ECO:0000313|Proteomes:UP000030143};
RN [1] {ECO:0000313|EMBL:KGO50219.1, ECO:0000313|Proteomes:UP000030143}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MD-8 {ECO:0000313|EMBL:KGO50219.1,
RC ECO:0000313|Proteomes:UP000030143};
RX PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome, transcriptome, and functional analyses of Penicillium expansum
RT provide new insights into secondary metabolism and pathogenicity.";
RL Mol. Plant Microbe Interact. 28:232-248(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO50219.1}.
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DR EMBL; JQFZ01000345; KGO50219.1; -; Genomic_DNA.
DR RefSeq; XP_016593470.1; XM_016740059.1.
DR AlphaFoldDB; A0A0A2K1R9; -.
DR STRING; 27334.A0A0A2K1R9; -.
DR GeneID; 27675478; -.
DR VEuPathDB; FungiDB:PEXP_009030; -.
DR HOGENOM; CLU_016813_1_1_1; -.
DR OrthoDB; 6075923at2759; -.
DR PhylomeDB; A0A0A2K1R9; -.
DR Proteomes; UP000030143; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:TreeGrafter.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF4; SOLUTE CARRIER FAMILY 28 MEMBER 3; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030143};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..266
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 284..381
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 387..599
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
FT REGION 60..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 613 AA; 67823 MW; 4B645F6FB486DE9E CRC64;
MDKTQEANPV GSQVVHHVDP VLEPENQHHH SHQHHTAFAE EGRQDEVVYS KDAQFEKGIV
PEQSPLDHGS KNSKDEEAGE NFPAQRTWYR RVGKQWRHIA HAVVWLLFTG GWLIPFLLYL
AITLRIIFFY VPITIISRPM QWVWERTAHP FVRMIPEKIR VPSAAALCIG VILIGSFVSE
ESQDNTRANR AVSLFGMVVF IFGLWLTSRN RKKIIWHTVI VGMLAQFIIA LFVLRTTAGY
DIFNFISGLA TDLLGFAADG VIFLTSEDFY NFHDGFSPGS FFIVSVISAI IFFVSFVQLL
YYYNILQWFI GKFAVFFFWS MRVSGAEAVV AAASPFIGQG ESAMLIRPFI AHLTMAELHQ
VMCSGFATIA GSVLIAYISI GVNPQAMVSA CVMSIPASLA VSKLRWPEEE ETLTAGRVVV
PDDDEHRSAN ALHAFTSGTW LGLKIAAMIA STLLCIIALI GLINGLLTWW GRYLSINDPP
LTLELIVGYI CYPIAFLLGV SRDGDLLKVG KLIGTKLVTN EFVAYEALQN NAEYKDLSDR
SRLIVTYALC GFANIGSLGN QIGVLSQIAP GRSNDVSRVA FSAMVTGAIS TFTSATIAGL
LITNEKQYFG TST
//
