ID A0A0B1T7C1_OESDE Unreviewed; 288 AA.
AC A0A0B1T7C1;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 28-JAN-2026, entry version 31.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=OESDEN_08075 {ECO:0000313|EMBL:KHJ92046.1};
OS Oesophagostomum dentatum (Nodular worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Strongylidae; Oesophagostomum.
OX NCBI_TaxID=61180 {ECO:0000313|EMBL:KHJ92046.1, ECO:0000313|Proteomes:UP000053660};
RN [1] {ECO:0000313|EMBL:KHJ92046.1, ECO:0000313|Proteomes:UP000053660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OD-Hann {ECO:0000313|EMBL:KHJ92046.1,
RC ECO:0000313|Proteomes:UP000053660};
RA Mitreva M.;
RT "Draft genome of the hookworm Oesophagostomum dentatum.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; KN551609; KHJ92046.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B1T7C1; -.
DR OrthoDB; 428480at2759; -.
DR Proteomes; UP000053660; Unassembled WGS sequence.
DR GO; GO:0005764; C:lysosome; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006689; P:ganglioside catabolic process; IEA:TreeGrafter.
DR GO; GO:0030203; P:glycosaminoglycan metabolic process; IEA:TreeGrafter.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR017853; GH.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KHJ92046.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053660}.
FT DOMAIN 41..101
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 124..258
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
SQ SEQUENCE 288 AA; 32900 MW; 4C0FDAC761F29F9D CRC64;
MNRTLSPDNI SFDLGQKESC DVLQMNAEIY LTKWMFPFPV AMKRNADSFV VTVKVARDCP
EHVPRHGESE EYKLVVTMDG ATISAETVWG AIRGIDSLSQ LIFYDRSKSK YNIRTVEIHD
FPRFPVRGVM IDTSRHYLST KIIKRQLDIM AMNKMNVLHW HVVDSESFPF VSRKFPNLST
VGAYSPKHLY SPTDVQEIIE FARIRGIRVI PEFDLPGHTG SWRGQPGLLT ECYDKAGHPT
NLPNLVDPSN EDNFKFLEVS LHAYQQNCNI FCKIYFKGVS GRSDGNIC
//
