ID A0A0B2VRT8_TOXCA Unreviewed; 1149 AA.
AC A0A0B2VRT8;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 28-JAN-2026, entry version 46.
DE SubName: Full=Collagen alpha-1(XVIII) chain {ECO:0000313|EMBL:KHN84383.1};
GN Name=COL18A1 {ECO:0000313|EMBL:KHN84383.1};
GN ORFNames=Tcan_12230 {ECO:0000313|EMBL:KHN84383.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN84383.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN84383.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN84383.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN84383.1}.
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DR EMBL; JPKZ01000987; KHN84383.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VRT8; -.
DR STRING; 6265.A0A0B2VRT8; -.
DR OMA; AREANFR; -.
DR OrthoDB; 5983381at2759; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050938; Collagen_Structural_Proteins.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR37456:SF6; COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2; 1.
DR PANTHER; PTHR37456; SI:CH211-266K2.1; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119, ECO:0000313|EMBL:KHN84383.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1149
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002077538"
FT DOMAIN 623..668
FT /note="Collagen type XV/XVIII trimerization"
FT /evidence="ECO:0000259|Pfam:PF20010"
FT DOMAIN 966..1131
FT /note="Collagenase NC10/endostatin"
FT /evidence="ECO:0000259|Pfam:PF06482"
FT REGION 151..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..299
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..426
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..439
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..472
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..583
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..600
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..610
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..831
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..859
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..947
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1149 AA; 127328 MW; 4D926BBA0BD9A84C CRC64;
MPPQRALLLA FVALAFVLVR NASAAVANPS SKQNDKSNAQ VQRDVEDLIV NEGFLLTTVK
QPQNQPKNVP TVQPKRPPFH GPVAFKPHIA SLNRTRLSLR RPKRTHRPKV HKTVRPHATT
PIRNLSRPSV LKSIKPLVKV APPVRVPTRL EQRLRRKANN EEEGSDSREP VPLDPIFVEQ
NGGNAQITVV APGGEGPTIA SSENQPTRDA PFQPHIVEEE ENVFPIAFEE VQVVEPEGGD
FSAEYDQEGE LDDGVATQTF LPEDHLGAFQ EMRISDDPND AAVSCDDENE GSGMEEEAEA
ISKVVEPEPA TPSGERPSYP QDGRKLQLIV SDHSDSLILP FYHLDTKAYK QHATSVSTNH
LPEYNEPDAK PGRGEKGEKG EKGDKGDKGD QGEPGPPGPV GPPGVCMAEC RDGRDGMPGP
RGEQGPMGPP GPPGPPGPPG QVIQQGMEDS GYPIQAIAGP PGPQGPPGPQ GPMGPRGDPG
VGIPGPPGPP GRYMGLTQED IDRIVSDPRL RAQQSECCTP ARQFPGTETG TDELPAYNPA
VHRFTMKGEK GERGEHGPMG APGPMGPQGP MGPMGPMGIQ GPVGPVGPAG PPGPPGPPGP
AGSAQPGSPS CPQTPPGATP GCVQVFQTSI ELFSSSGGIP LGSLSFSISS QQLFIRVNGG
WKEVRLEGFH PTLEQRPSLE INLDSQNENY IPYWLSDEAA VSVHAPCVRR SVPVEVSIQP
HPPQPQERPQ YVPESRPEYR PEHRPEYRPE YPPHRRPDYE VLRRPHPGPE HRPEPRPHYR
PGQRPEITIE RHPYHHHERP SESLPKQLQP HEWPEVLPEH HEHRPEPEEG RSPGYRPEQY
SGAQRQPEPI QQQSSQIPIR RPEIQPEQQV PHPEERAEQV AQEEHPEPQL EHRPELVSER
QRQIEGELRP IEHPAPTIYP PYPERPRYPE PERQPHYRER PTPEPHRPRY PPTRRPYTLG
EKDHVLHLIA LNTPMTGNMR GVRGADLACY QQARQAGFRT TFRAFLSSHV QDLNKVVHFG
DRETPVVNLR GERLFNSWSD IFRERPMFDA PLYSFNRRNV FDDNTWREKR VWHGSDASGT
RSESGYCNAW RSSDPSQVGS SSSIGPRLPL LDGCQNVDCS HEFVVLCVEN MSKYSVDKRL
GKKRMHYEE
//
