ID A0A0C1R815_9CYAN Unreviewed; 430 AA.
AC A0A0C1R815;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 18-JUN-2025, entry version 40.
DE RecName: Full=Proton extrusion protein PxcA {ECO:0000256|HAMAP-Rule:MF_01308};
GN Name=pxcA {ECO:0000256|HAMAP-Rule:MF_01308};
GN ORFNames=DA73_0227985 {ECO:0000313|EMBL:KIE08425.1}, DA73_0400039185
GN {ECO:0000313|EMBL:KAF3883755.1};
OS Tolypothrix bouteillei VB521301.
OC Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Nostocales;
OC Tolypothrichaceae; Tolypothrix.
OX NCBI_TaxID=1479485 {ECO:0000313|EMBL:KIE08425.1};
RN [1] {ECO:0000313|EMBL:KIE08425.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VB521301 {ECO:0000313|EMBL:KIE08425.1};
RX PubMed=25700407;
RA Chandrababunaidu M.M., Singh D., Sen D., Bhan S., Das S., Gupta A.,
RA Adhikary S.P., Tripathy S.;
RT "Draft Genome Sequence of Tolypothrix boutellei Strain VB521301.";
RL Genome Announc. 3:e00001-15(2015).
RN [2] {ECO:0000313|EMBL:KAF3883755.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VB521301 {ECO:0000313|EMBL:KAF3883755.1};
RA Sarangi A.N., Mukherjee M., Ghosh S., Singh D., Das A., Kant S., Prusty A.,
RA Tripathy S.;
RT "Improved Assembly of Tolypothrix boutellei genome.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for H(+) efflux immediately after light irradiation
CC to form a rapid H(+) concentration gradient across the thylakoid
CC membranes. Together with PxcL, contributes to transient H(+) uptake
CC following dark to light transition. {ECO:0000256|HAMAP-Rule:MF_01308}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_01308}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_01308}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CemA family. {ECO:0000256|HAMAP-
CC Rule:MF_01308}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIE08425.1}.
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DR EMBL; JHEG04000002; KAF3883755.1; -; Genomic_DNA.
DR EMBL; JHEG02000058; KIE08425.1; -; Genomic_DNA.
DR RefSeq; WP_038080833.1; NZ_JHEG04000002.1.
DR AlphaFoldDB; A0A0C1R815; -.
DR STRING; 1479485.DA73_0227985; -.
DR OrthoDB; 418298at2; -.
DR Proteomes; UP000029738; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01308; CemA_PxcA; 1.
DR InterPro; IPR004282; CemA.
DR PANTHER; PTHR33650:SF2; CHLOROPLAST ENVELOPE MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR33650; CHLOROPLAST ENVELOPE MEMBRANE PROTEIN-RELATED; 1.
DR Pfam; PF03040; CemA; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01308};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01308};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781, ECO:0000256|HAMAP-
KW Rule:MF_01308};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065, ECO:0000256|HAMAP-
KW Rule:MF_01308};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01308};
KW Reference proteome {ECO:0000313|Proteomes:UP000029738};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01308};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01308};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01308}.
FT TRANSMEM 206..223
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01308"
FT TRANSMEM 307..326
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01308"
FT TRANSMEM 352..371
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01308"
FT TRANSMEM 391..410
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01308"
SQ SEQUENCE 430 AA; 49007 MW; 7887C6974A2D305D CRC64;
MKNYITPSKS DKFLNKINHF LHESNQWFFN TSERALEQAY QIALKIKNIE LEHFGGDKVS
TQGGEYSQNV LDCFQTDVEK YLNTIKIRIA EFKISRFFLK NSNYAFLEKL KLIDEVLTRY
NEREVEISRS ASEDSPQKSI LSKLEYSQPL LKSSSQLSSS GIEPVTQKTG ILPRSIGKTI
RKITNDISRN SEEEVVRTFQ ASRKTTRLAI NFLGLLILIP LLTQEVSKHF LILPAVEHFR
SGESTSIFLN WEMKEEAFKQ LQSFEEELKF ERLLKHSPQI SSEAIEEKVS VKVMEIAEEF
KRKSNSAVAN VFADLLGLVA FAGVVLTNKR GVAAVKTLLN EIVYGLSDSA KAFIIILFTD
IFVGFHSPHG WEVILESIAT HLGIPADRNA IFLFIATFPV ILDTIFKYWV FRYLNQISPS
AVATLKNMNE
//
