ID A0A0D9S3K6_CHLSB Unreviewed; 209 AA.
AC A0A0D9S3K6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 28-JAN-2026, entry version 48.
DE RecName: Full=T-cell surface glycoprotein CD3 gamma chain {ECO:0000256|ARBA:ARBA00018021};
DE AltName: Full=T-cell receptor T3 gamma chain {ECO:0000256|ARBA:ARBA00030773};
GN Name=CD3G {ECO:0000313|Ensembl:ENSCSAP00000015445.1};
OS Chlorocebus sabaeus (Green monkey) (Simia sabaea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000015445.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000015445.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000015445.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSCSAP00000015445.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell
CC surface that plays an essential role in adaptive immune response. When
CC antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-
CC mediated signals are transmitted across the cell membrane by the CD3
CC chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor
CC tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.
CC Upon TCR engagement, these motifs become phosphorylated by Src family
CC protein tyrosine kinases LCK and FYN, resulting in the activation of
CC downstream signaling pathways. In addition to this role of signal
CC transduction in T-cell activation, CD3G plays an essential role in the
CC dynamic regulation of TCR expression at the cell surface. Indeed,
CC constitutive TCR cycling is dependent on the di-leucine-based (diL)
CC receptor-sorting motif present in CD3G.
CC {ECO:0000256|ARBA:ARBA00045637}.
CC -!- SUBUNIT: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E
CC heterodimers that preferentially associate with TCRalpha and TCRbeta,
CC respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers.
CC In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3
CC complex. Alternatively, TCRalpha and TCRbeta can be replaced by
CC TCRgamma and TCRdelta. {ECO:0000256|ARBA:ARBA00011588}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AQIB01091078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01091079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01091080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01091081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01091082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008019242.1; XM_008021051.3.
DR AlphaFoldDB; A0A0D9S3K6; -.
DR STRING; 60711.ENSCSAP00000015445; -.
DR Ensembl; ENSCSAT00000000616.1; ENSCSAP00000015445.1; ENSCSAG00000002599.1.
DR GeneID; 103248587; -.
DR KEGG; csab:103248587; -.
DR CTD; 917; -.
DR eggNOG; ENOG502S4XC; Eukaryota.
DR GeneTree; ENSGT00940000153312; -.
DR OMA; QYGHLQG; -.
DR OrthoDB; 8941324at2759; -.
DR BioGRID-ORCS; 103248587; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 1.
DR Bgee; ENSCSAG00000002599; Expressed in blood and 2 other cell types or tissues.
DR GO; GO:0042105; C:alpha-beta T cell receptor complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:TreeGrafter.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IEA:Ensembl.
DR GO; GO:0045059; P:positive thymic T cell selection; IEA:TreeGrafter.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0070228; P:regulation of lymphocyte apoptotic process; IEA:Ensembl.
DR FunFam; 2.60.40.10:FF:001337; T-cell surface glycoprotein CD3 gamma chain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR015484; CD3_esu/gsu/dsu.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032052; Ig_4.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR PANTHER; PTHR10570:SF8; T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN; 1.
DR PANTHER; PTHR10570; T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN / DELTA CHAIN; 1.
DR Pfam; PF16680; Ig_4; 1.
DR Pfam; PF02189; ITAM; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00077; ITAM; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS51055; ITAM_1; 1.
PE 4: Predicted;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 139..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..121
FT /note="Immunoglobulin subtype 2"
FT /evidence="ECO:0000259|SMART:SM00408"
SQ SEQUENCE 209 AA; 23437 MW; 793E2B13307ED24D CRC64;
MGGASLAAAQ AGWLLRAAPC FCQRTETDME QGKGLTGFTL AIILLQGSLA QSFEENRKLN
VYNQEDGSVL LTCHVKNTNI TWFKEGKMID ILTAHKNKWN LGSNTKDPRG VYQCKGSKDK
SKTLQVYYRM CQNCIELNAA TILGFVFAEI VSIFFLAVGV YFIAGQDGVR QSRASDKQTL
LPNDQLYQPL KDREDDQYSH LQGNQLRRN
//
