ID A0A0E3UP46_9GAMM Unreviewed; 503 AA.
AC A0A0E3UP46;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 28-JAN-2026, entry version 41.
DE RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN Name=nusA {ECO:0000256|HAMAP-Rule:MF_00945,
GN ECO:0000313|EMBL:AKC87736.1};
GN ORFNames=WQ53_14200 {ECO:0000313|EMBL:AKC87736.1};
OS Pseudoxanthomonas suwonensis.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Lysobacterales; Lysobacteraceae; Pseudoxanthomonas.
OX NCBI_TaxID=314722 {ECO:0000313|EMBL:AKC87736.1, ECO:0000313|Proteomes:UP000033067};
RN [1] {ECO:0000313|EMBL:AKC87736.1, ECO:0000313|Proteomes:UP000033067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J1 {ECO:0000313|EMBL:AKC87736.1,
RC ECO:0000313|Proteomes:UP000033067};
RX PubMed=26067962;
RA Hou L., Jiang J., Xu Z., Zhou Y., Leung F.C.;
RT "Complete Genome Sequence of Pseudoxanthomonas suwonensis Strain J1, a
RT Cellulose-Degrading Bacterium Isolated from Leaf- and Wood-Enriched Soil.";
RL Genome Announc. 3:e00614-15(2015).
CC -!- FUNCTION: Participates in both transcription termination and
CC antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
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DR EMBL; CP011144; AKC87736.1; -; Genomic_DNA.
DR RefSeq; WP_052633347.1; NZ_CP011144.1.
DR AlphaFoldDB; A0A0E3UP46; -.
DR KEGG; psuw:WQ53_14200; -.
DR PATRIC; fig|314722.6.peg.3075; -.
DR eggNOG; COG0195; Bacteria.
DR OrthoDB; 9807233at2; -.
DR Proteomes; UP000033067; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-UniRule.
DR GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR CDD; cd02134; KH-II_NusA_rpt1; 1.
DR CDD; cd22529; KH-II_NusA_rpt2; 1.
DR CDD; cd04455; S1_NusA; 1.
DR FunFam; 1.10.150.20:FF:000018; Transcription termination/antitermination protein NusA; 1.
DR FunFam; 2.40.50.140:FF:000058; Transcription termination/antitermination protein NusA; 1.
DR FunFam; 3.30.1480.10:FF:000001; Transcription termination/antitermination protein NusA; 1.
DR FunFam; 3.30.300.20:FF:000002; Transcription termination/antitermination protein NusA; 1.
DR FunFam; 3.30.300.20:FF:000005; Transcription termination/antitermination protein NusA; 1.
DR Gene3D; 3.30.300.20; -; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.30.1480.10; NusA, N-terminal domain; 1.
DR HAMAP; MF_00945_B; NusA_B; 1.
DR InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR058582; KH_NusA_2nd.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR036555; NusA_N_sf.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR010213; TF_NusA.
DR InterPro; IPR030842; TF_NusA_bacterial.
DR InterPro; IPR025249; TF_NusA_KH_1st.
DR InterPro; IPR013735; TF_NusA_N.
DR InterPro; IPR010214; Tscrpt_termin_fac_NusA_C_rpt.
DR NCBIfam; TIGR01953; NusA; 1.
DR NCBIfam; TIGR01954; nusA_Cterm_rpt; 2.
DR PANTHER; PTHR22648; TRANSCRIPTION TERMINATION FACTOR NUSA; 1.
DR PANTHER; PTHR22648:SF0; TRANSCRIPTION TERMINATION_ANTITERMINATION PROTEIN NUSA; 1.
DR Pfam; PF14520; HHH_5; 2.
DR Pfam; PF13184; KH_NusA_1st; 1.
DR Pfam; PF26594; KH_NusA_2nd; 1.
DR Pfam; PF08529; NusA_N; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 2.
DR SUPFAM; SSF47794; Rad51 N-terminal domain-like; 2.
DR SUPFAM; SSF69705; Transcription factor NusA, N-terminal domain; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00945};
KW Elongation factor {ECO:0000313|EMBL:AKC87736.1};
KW Protein biosynthesis {ECO:0000313|EMBL:AKC87736.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033067};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription antitermination {ECO:0000256|ARBA:ARBA00022814,
KW ECO:0000256|HAMAP-Rule:MF_00945};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription termination {ECO:0000256|ARBA:ARBA00022472,
KW ECO:0000256|HAMAP-Rule:MF_00945}.
FT DOMAIN 139..204
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 503 AA; 55173 MW; 8B072A82028B8141 CRC64;
MSKELLLVVD AVANEKGVPR DVIFDALEAA LASAAKKRYV DQDVVTRVAI DRKDGSYETF
RRWEVVADDV VMESPDRQIR LMDAVDEADG VEVGDWIEEQ IENPEFGRIA AQAAKQVIVQ
RVREAERQQV VDAWTDRVGE LVTGVVKRAE RGNIYVDLGG NAEAFIPKDK GIPRDVLRTG
DRVRGYLYEV RSEPRGPQLF ISRGAPEFMI ELFKLEVPEV GQGLVEIKAC ARDPGDRAKI
AVIAHDTRTD PIGACIGMRG SRVQAVSNEL NGERVDIVLW NDNPANFVIN AMAPAEVQSI
IVDEDKHSMD LAVAEDRLAQ AIGKGGQNVR LASRLTGWQL NVMTQDQVAA KSEAEQAVAR
QLFMDKLEVD EEIAGILVAE GFSTVEEIAY VPVGELLAVE GFDEDIVEEL RSRARDALLN
EALAVEEELD EHQPAEDLLA LEGMDEETAF ALASHGVRTS EDLSDLAADE VAEFGIEGLD
EARAAALILA ARAEEIARLE RGA
//
