ID A0A0F5JUV3_9BURK Unreviewed; 644 AA.
AC A0A0F5JUV3;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 02-APR-2025, entry version 33.
DE SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:KKB61082.1};
GN ORFNames=WM40_25295 {ECO:0000313|EMBL:KKB61082.1};
OS Robbsia andropogonis.
OC Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC Burkholderiales; Burkholderiaceae; Robbsia.
OX NCBI_TaxID=28092 {ECO:0000313|EMBL:KKB61082.1, ECO:0000313|Proteomes:UP000033618};
RN [1] {ECO:0000313|EMBL:KKB61082.1, ECO:0000313|Proteomes:UP000033618}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICMP2807 {ECO:0000313|EMBL:KKB61082.1,
RC ECO:0000313|Proteomes:UP000033618};
RA Lopes-Santos L., Castro D.B., Ottoboni L.M., Park D., Weirc B.S.,
RA Destefano S.A.;
RT "Draft Genome Sequence of Burkholderia andropogonis type strain ICMP2807,
RT isolated from Sorghum bicolor.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKB61082.1}.
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DR EMBL; LAQU01000076; KKB61082.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F5JUV3; -.
DR STRING; 28092.WM40_25295; -.
DR PATRIC; fig|28092.6.peg.5972; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000033618; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000033618};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 11..298
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 312..631
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 644 AA; 71795 MW; 85F7E80A6D5B3B2A CRC64;
MDPQALHHAV DTATERLISD QRADGHWLYE LEADATIPSE YVLMVHYLGE TPDLTLEAKI
GRYLRRIQGY HGGWPLYHEG PLDISASVKA YFALKMIGDP VDAPHMQRAR EAILAAGGIA
KVNVFTRILL ALYGVVSWRA VPMMPIEIML LPSWFPFHLS KVSYWARTVI VPLLVLQQER
PRARNPRGIR LDELFTGPAV NVGLNDRAPQ QSAGWFRTFR GIDAVLRVTE WIIPRRLHAR
ATQAAISFVS SHLNGEDGLG AIFPAMVNTV MMYDVLGFPP THPERAIARR SVDKLLVVDP
SEDGEAYCQP CLSPVWDTAL ASHALLESGT PQATAAALRG AEWLRPLQII DVIGDWSSRR
PTVRPGGWAF QYRNDYYPDV DDTAVVALMM DRLSGQADFT KSIARAREWV VGMQSGDGGW
GAFEPENTHE YLNNIPFADH GALLDPPTVD VSARCLSMLT QLGASRDDPS VAHATDYILM
HQESDGSWYG RWGMNYIYGT WAALCALNGV GIDAHQSPLI QKAVDWLFSI QNADGGWGED
GDSYRLHYDG YRRATSTASQ TAWALLGLMS AGVVDDPRVA RGITYLMTHQ AGDGFWDEPL
FTATGFPRVF YLRYHGYSKY FPLWALARYR NLARDGKRHV TLGL
//
