ID A0A0H1B3Y5_9EURO Unreviewed; 1743 AA.
AC A0A0H1B3Y5;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 18-JUN-2025, entry version 42.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=EMPG_10422 {ECO:0000313|EMBL:KLJ06149.1};
OS Blastomyces silverae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ06149.1, ECO:0000313|Proteomes:UP000053573};
RN [1] {ECO:0000313|Proteomes:UP000053573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) +
CC diphosphate; Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00048552,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLJ06149.1}.
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DR EMBL; LDEV01003278; KLJ06149.1; -; Genomic_DNA.
DR STRING; 2060906.A0A0H1B3Y5; -.
DR OrthoDB; 270392at2759; -.
DR Proteomes; UP000053573; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0005665; C:RNA polymerase II, core complex; IEA:TreeGrafter.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd02584; RNAP_II_Rpb1_C; 1.
DR CDD; cd02733; RNAP_II_RPB1_N; 1.
DR FunFam; 2.40.40.20:FF:000019; DNA-directed RNA polymerase II subunit RPB1; 1.
DR FunFam; 1.10.132.30:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR FunFam; 1.10.150.390:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR FunFam; 1.10.274.100:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR FunFam; 3.30.1360.140:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR FunFam; 4.10.860.120:FF:000002; DNA-directed RNA polymerase subunit; 1.
DR FunFam; 4.10.860.120:FF:000003; DNA-directed RNA polymerase subunit; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.1360.140; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 2.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR000684; RNA_pol_II_repeat_euk.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR007075; RNA_pol_Rpb1_6.
DR InterPro; IPR007073; RNA_pol_Rpb1_7.
DR InterPro; IPR038593; RNA_pol_Rpb1_7_sf.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR NCBIfam; NF006336; PRK08566.1; 1.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR Pfam; PF04992; RNA_pol_Rpb1_6; 1.
DR Pfam; PF04990; RNA_pol_Rpb1_7; 1.
DR Pfam; PF05001; RNA_pol_Rpb1_R; 12.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
DR PROSITE; PS00115; RNA_POL_II_REPEAT; 3.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053573};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 246..553
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 154..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1501..1743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1555
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1566..1594
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1602..1676
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1687..1743
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1743 AA; 192922 MW; F18EBCCD7B5F1124 CRC64;
MASVKFPYSK AQLRTIKEIQ FGLLSPEEIK RMSVVHVEYP ETMDEQRQRP REKGLNDPRL
GTIDRNWRCA TCEEGINDCP GHFGHIELST PVFHIGFLTK IKKLLETVCH NCGKIKANTT
DQKYLEALRF RDPKRRFDAI WRLSKDVLIC EADPSPDDDD PFGKEPSKPV RSHGGCGNMQ
PQIRKEGISL VGTWKPSKNR DMMDDMDVQQ PEKRQITPQM ALNIFKTISE EDVRLMGLSN
DYARPEWMII TVLPVPPPPV RPSVLVGGSG SGQRGEDDLT YKLAEIVRAN QNVTRCEQEG
SPEHVVREFE SLLQYHVATY MDNDIAGQPQ AMQKSNRPVK AIRGRLKGKE GRLRQNLMGK
RVDFSARTVI TGDPNLSLDE VGVPLSIAQT LTYPEVVTPF NIAKLGELVD NGPDIHPGAR
YVIRNTGERI DLRHHKGGGG RNFLQYGWRV ERHIVDGDVI LFNRQPSLHK ESMMGHRIRV
MPYSTFRLNL SVTTPYNADF DGDEMNLHVP QSEEARAELS QLCMVPLQIV SPQRNGPLMG
IVQDTLCGIY KICARDVFLT KEQVMNILLW VPDWDGVIPQ PAILKPRPRW TGKQVISMVL
PAGLNLLRVD RDKAPLSEKF SPLNDGGLLV HSGELMYGMF SKKTVGATGG GVIHTIFNEY
GPEMAMNFFN GAQTVVNYWL LHHGFSIGIG DTIPDLATIQ KIEEAVRVRK EEVDEITASA
TDNTLEPLPG MNVRETFESK VSRALNNARD EAGTETEKSF KDLNNAVQMA RSGSKGSIIN
ISQMTAVVGQ QSVEGKRIPF GFKYRTLPHF TKDDYSPESR GFVENSYLRG LTPTEFFFHA
MAGREGLIDT AVKTAETGYI QRKLVKALEE VMVKYDGTVR NSLGDVVQFL YGEDGLDGAH
IENQRVDIIK CSDERFRDRY RIDLMDPERT LSPNVLEQAT EIAGDIEVQK YLDEEWEQLL
KDRAFMRSVA KEDDEMMQLP INVQRILESA KTIFRIREGA ISDLHPAEVI PQIRALLDRL
IVVRGDDVIS REAQESATLL FKAQLRSRLA FRRLVVEYSL NRLAFQHVLG AIESRFSKAM
ANPGEMVGVL AAQSIGEPAT QMTLNTFHFA GVSSKNVTLG VPRLKEILNV ATHIKTPSMT
VYQDPSRAMD KESVKQLRSV VEHTSLRSVT EATEIYYDPD IQSTVIEADR DMVESYFIIP
EDVADDSSRQ SKWLLRIILS RPKLLDKSLT VQDVAMKIKD AYPQDIAVIF SDNNADEQVI
RIRQMQDSKQ DDDDDDTEYD VTLKKLESHL LDTLTLRGVA GIERAFINEK SRVRVLEDGS
LHQSTEDPLC KEWVLETSGS ALGEVLTIPG VDTTRTYSNQ FIEILEVFGI EATRTALLRE
LTQVLAFDGS YVNHRHLALL VDVMTSRGFL MAVTRHGINR ADTGALMRCS FEETVEILLD
AAAFAELDDC RGVSENLILG QMAPAGTGEF DVYLDQDMLM GVVSSNAGLM TTDGKGLLGD
GAATPYDSSS PLQDNMYIGT PDPDSNFSPI RQAGSETPAG FTEYQPSGFS GGFSPHGARS
PGGGYSPTSP FNTSPTSPRY SPSSGYSPTS PGMSITSPRF MSSPGFSPAS PAFAPTSPAY
SPTSPGYQQS PTSPSYSPTS PGFSPTSPSY SPTSPSFSPA SPAFSPTSPS YSPTSPALGI
STGRHLSPTS PTSPKYTPTS PGWSPTSPET YSPTSPNFSG SPTSPGGPTS PGYSPTSPTF
NPT
//