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Database: UniProt
Entry: A0A0H1B3Y5_9EURO
LinkDB: A0A0H1B3Y5_9EURO
Original site: A0A0H1B3Y5_9EURO 
ID   A0A0H1B3Y5_9EURO        Unreviewed;      1743 AA.
AC   A0A0H1B3Y5;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   18-JUN-2025, entry version 42.
DE   RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE            EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN   ORFNames=EMPG_10422 {ECO:0000313|EMBL:KLJ06149.1};
OS   Blastomyces silverae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ06149.1, ECO:0000313|Proteomes:UP000053573};
RN   [1] {ECO:0000313|Proteomes:UP000053573}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       {ECO:0000256|RuleBase:RU004279}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) +
CC         diphosphate; Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00048552,
CC         ECO:0000256|RuleBase:RU004279};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC       {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KLJ06149.1}.
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DR   EMBL; LDEV01003278; KLJ06149.1; -; Genomic_DNA.
DR   STRING; 2060906.A0A0H1B3Y5; -.
DR   OrthoDB; 270392at2759; -.
DR   Proteomes; UP000053573; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0005665; C:RNA polymerase II, core complex; IEA:TreeGrafter.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd02584; RNAP_II_Rpb1_C; 1.
DR   CDD; cd02733; RNAP_II_RPB1_N; 1.
DR   FunFam; 2.40.40.20:FF:000019; DNA-directed RNA polymerase II subunit RPB1; 1.
DR   FunFam; 1.10.132.30:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR   FunFam; 1.10.150.390:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR   FunFam; 1.10.274.100:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR   FunFam; 3.30.1360.140:FF:000001; DNA-directed RNA polymerase subunit; 1.
DR   FunFam; 4.10.860.120:FF:000002; DNA-directed RNA polymerase subunit; 1.
DR   FunFam; 4.10.860.120:FF:000003; DNA-directed RNA polymerase subunit; 1.
DR   Gene3D; 1.10.132.30; -; 1.
DR   Gene3D; 1.10.150.390; -; 1.
DR   Gene3D; 2.40.40.20; -; 1.
DR   Gene3D; 3.30.1360.140; -; 1.
DR   Gene3D; 6.10.250.2940; -; 1.
DR   Gene3D; 6.20.50.80; -; 1.
DR   Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR   Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 2.
DR   Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR   InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR   InterPro; IPR000722; RNA_pol_asu.
DR   InterPro; IPR000684; RNA_pol_II_repeat_euk.
DR   InterPro; IPR006592; RNA_pol_N.
DR   InterPro; IPR007080; RNA_pol_Rpb1_1.
DR   InterPro; IPR007066; RNA_pol_Rpb1_3.
DR   InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR   InterPro; IPR007083; RNA_pol_Rpb1_4.
DR   InterPro; IPR007081; RNA_pol_Rpb1_5.
DR   InterPro; IPR007075; RNA_pol_Rpb1_6.
DR   InterPro; IPR007073; RNA_pol_Rpb1_7.
DR   InterPro; IPR038593; RNA_pol_Rpb1_7_sf.
DR   InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR   InterPro; IPR038120; Rpb1_funnel_sf.
DR   NCBIfam; NF006336; PRK08566.1; 1.
DR   PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR   PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR   Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR   Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR   Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR   Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR   Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR   Pfam; PF04992; RNA_pol_Rpb1_6; 1.
DR   Pfam; PF04990; RNA_pol_Rpb1_7; 1.
DR   Pfam; PF05001; RNA_pol_Rpb1_R; 12.
DR   SMART; SM00663; RPOLA_N; 1.
DR   SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
DR   PROSITE; PS00115; RNA_POL_II_REPEAT; 3.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW   ECO:0000256|RuleBase:RU004279}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053573};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004279};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          246..553
FT                   /note="RNA polymerase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00663"
FT   REGION          154..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1501..1743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1546..1555
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1566..1594
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1602..1676
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1687..1743
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1743 AA;  192922 MW;  F18EBCCD7B5F1124 CRC64;
     MASVKFPYSK AQLRTIKEIQ FGLLSPEEIK RMSVVHVEYP ETMDEQRQRP REKGLNDPRL
     GTIDRNWRCA TCEEGINDCP GHFGHIELST PVFHIGFLTK IKKLLETVCH NCGKIKANTT
     DQKYLEALRF RDPKRRFDAI WRLSKDVLIC EADPSPDDDD PFGKEPSKPV RSHGGCGNMQ
     PQIRKEGISL VGTWKPSKNR DMMDDMDVQQ PEKRQITPQM ALNIFKTISE EDVRLMGLSN
     DYARPEWMII TVLPVPPPPV RPSVLVGGSG SGQRGEDDLT YKLAEIVRAN QNVTRCEQEG
     SPEHVVREFE SLLQYHVATY MDNDIAGQPQ AMQKSNRPVK AIRGRLKGKE GRLRQNLMGK
     RVDFSARTVI TGDPNLSLDE VGVPLSIAQT LTYPEVVTPF NIAKLGELVD NGPDIHPGAR
     YVIRNTGERI DLRHHKGGGG RNFLQYGWRV ERHIVDGDVI LFNRQPSLHK ESMMGHRIRV
     MPYSTFRLNL SVTTPYNADF DGDEMNLHVP QSEEARAELS QLCMVPLQIV SPQRNGPLMG
     IVQDTLCGIY KICARDVFLT KEQVMNILLW VPDWDGVIPQ PAILKPRPRW TGKQVISMVL
     PAGLNLLRVD RDKAPLSEKF SPLNDGGLLV HSGELMYGMF SKKTVGATGG GVIHTIFNEY
     GPEMAMNFFN GAQTVVNYWL LHHGFSIGIG DTIPDLATIQ KIEEAVRVRK EEVDEITASA
     TDNTLEPLPG MNVRETFESK VSRALNNARD EAGTETEKSF KDLNNAVQMA RSGSKGSIIN
     ISQMTAVVGQ QSVEGKRIPF GFKYRTLPHF TKDDYSPESR GFVENSYLRG LTPTEFFFHA
     MAGREGLIDT AVKTAETGYI QRKLVKALEE VMVKYDGTVR NSLGDVVQFL YGEDGLDGAH
     IENQRVDIIK CSDERFRDRY RIDLMDPERT LSPNVLEQAT EIAGDIEVQK YLDEEWEQLL
     KDRAFMRSVA KEDDEMMQLP INVQRILESA KTIFRIREGA ISDLHPAEVI PQIRALLDRL
     IVVRGDDVIS REAQESATLL FKAQLRSRLA FRRLVVEYSL NRLAFQHVLG AIESRFSKAM
     ANPGEMVGVL AAQSIGEPAT QMTLNTFHFA GVSSKNVTLG VPRLKEILNV ATHIKTPSMT
     VYQDPSRAMD KESVKQLRSV VEHTSLRSVT EATEIYYDPD IQSTVIEADR DMVESYFIIP
     EDVADDSSRQ SKWLLRIILS RPKLLDKSLT VQDVAMKIKD AYPQDIAVIF SDNNADEQVI
     RIRQMQDSKQ DDDDDDTEYD VTLKKLESHL LDTLTLRGVA GIERAFINEK SRVRVLEDGS
     LHQSTEDPLC KEWVLETSGS ALGEVLTIPG VDTTRTYSNQ FIEILEVFGI EATRTALLRE
     LTQVLAFDGS YVNHRHLALL VDVMTSRGFL MAVTRHGINR ADTGALMRCS FEETVEILLD
     AAAFAELDDC RGVSENLILG QMAPAGTGEF DVYLDQDMLM GVVSSNAGLM TTDGKGLLGD
     GAATPYDSSS PLQDNMYIGT PDPDSNFSPI RQAGSETPAG FTEYQPSGFS GGFSPHGARS
     PGGGYSPTSP FNTSPTSPRY SPSSGYSPTS PGMSITSPRF MSSPGFSPAS PAFAPTSPAY
     SPTSPGYQQS PTSPSYSPTS PGFSPTSPSY SPTSPSFSPA SPAFSPTSPS YSPTSPALGI
     STGRHLSPTS PTSPKYTPTS PGWSPTSPET YSPTSPNFSG SPTSPGGPTS PGYSPTSPTF
     NPT
//
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