ID A0A0H2V4L3_ECOL6 Unreviewed; 1376 AA.
AC A0A0H2V4L3;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 18-JUN-2025, entry version 42.
DE SubName: Full=Haemoglobin protease {ECO:0000313|EMBL:AAN78874.1};
GN OrderedLocusNames=c0393 {ECO:0000313|EMBL:AAN78874.1};
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Enterobacterales; Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310 {ECO:0000313|EMBL:AAN78874.1, ECO:0000313|Proteomes:UP000001410};
RN [1] {ECO:0000313|EMBL:AAN78874.1, ECO:0000313|Proteomes:UP000001410}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC
RC {ECO:0000313|Proteomes:UP000001410};
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G.III., Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004571}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004571}. Cell surface
CC {ECO:0000256|ARBA:ARBA00004241}. Periplasm
CC {ECO:0000256|ARBA:ARBA00004418}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AE014075; AAN78874.1; -; Genomic_DNA.
DR SMR; A0A0H2V4L3; -.
DR STRING; 199310.c0393; -.
DR KEGG; ecc:c0393; -.
DR eggNOG; COG3210; Bacteria.
DR eggNOG; COG3468; Bacteria.
DR HOGENOM; CLU_000723_0_0_6; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd01343; PL1_Passenger_AT; 1.
DR Gene3D; 2.160.20.20; -; 1.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 3.30.160.280; -; 1.
DR Gene3D; 2.40.128.130; Autotransporter beta-domain; 1.
DR InterPro; IPR005546; Autotransporte_beta.
DR InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR InterPro; IPR012332; Autotransporter_pectin_lyase_C.
DR InterPro; IPR024973; ESPR.
DR InterPro; IPR006315; OM_autotransptr_brl_dom.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR000710; Peptidase_S6.
DR InterPro; IPR030396; Peptidase_S6_dom.
DR NCBIfam; TIGR01414; autotrans_barl; 1.
DR Pfam; PF03797; Autotransporter; 1.
DR Pfam; PF24078; Beta-sol_PIC_HAP1_IgA0_2nd; 1.
DR Pfam; PF13018; ESPR; 1.
DR Pfam; PF02395; Peptidase_S6; 1.
DR PRINTS; PR00921; IGASERPTASE.
DR SMART; SM00869; Autotransporter; 1.
DR SUPFAM; SSF103515; Autotransporter; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 2.
DR PROSITE; PS51208; AUTOTRANSPORTER; 1.
DR PROSITE; PS51691; PEPTIDASE_S6; 1.
PE 4: Predicted;
KW Cell outer membrane {ECO:0000256|ARBA:ARBA00023237};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00022452};
KW Periplasm {ECO:0000256|ARBA:ARBA00022764};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:AAN78874.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001410};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022452};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Virulence {ECO:0000256|ARBA:ARBA00023026};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 56..301
FT /note="Peptidase S6"
FT /evidence="ECO:0000259|PROSITE:PS51691"
FT DOMAIN 1110..1376
FT /note="Autotransporter"
FT /evidence="ECO:0000259|PROSITE:PS51208"
SQ SEQUENCE 1376 AA; 148019 MW; 69E23CEB9E5130B8 CRC64;
MNKIYALKYC YITNTVKVVS ELARRVCKGS TRRGKRLSVL TSLALSALLP TVAGASTVGG
NNPYQTYRDF AENKGQFQAG ATNIPIFNNK GELVGHLDKA PMVDFSSVNV SSNPGVATLI
NPQYIASVKH NKGYQSVSFG DGQNSYHIVD RNEHSSSDLH TPRLDKLVTE VAPATVTSSS
TADILNPSKY SAFYRAGSGS QYIQDSQGKR HWVTGGYGYL TGGILPTSFF YHGSDGIQLY
MGGNIHDHSI LPSFGEAGDS GSPLFGWNTA KGQWELVGVY SGVGGGTNLI YSLIPQSFLS
QIYSEDNDAP VFFNASSGAP LQWKFDSSTG TGSLKQGSDE YAMHGQKGSD LNAGKNLTFL
GHNGQIDLEN SVTQGAGSLT FTDDYTVTTS NGSTWTGAGI IVDKDASVNW QVNGVKGDNL
HKIGEGTLVV QGTGVNEGGL KVGDGTVVLN QQADSSGHVQ AFSSVNIASG RPTVVLADNQ
QVNPDNISWG YRGGVLDVNG NDLTFHKLNA ADYGATLGNS SDKTANITLD YQTRPADVKV
NEWSSSNRGT VGSLYIYNNP YTHTVDYFIL KTSSYGWFPT GQVSNEHWEY VGHDQNSAQA
LLANRINNKG YLYHGKLLGN INFSNKATPG TTGALVMDGS ANMSGTFTQE NGRLTIQGHP
VIHASTSQSI ANTVSSLGDN SVLTQPTSFT QDDWENRTFS FGSLVLKDTD FGLGRNATLN
TTIQADNSSV TLGDSRVFID KKDGQGTAFT LEEGTSVATK DADKSVFNGT VNLDNQSVLN
INEIFNGGIQ ANNSTVNISS DSAVLENSTL TSTALNLNKG ANVLASQSFV SDGPVNISDA
TLSLNSRPDE VSHTLLPVYD YAGSWNLKGD DARLNVGPYS MLSGNINVQD KGTVTLGGEG
ELSPDLTLQN QMLYSLFNGY RNTWSGSLNA PDATVSMTDT QWSMNGNSTA GNMKLNRTIV
GFNGGTSSFT TLTTDNLDAV QSAFVMRTDL NKADKLVINK SATGHDNSIW VNFLKKPSDK
DTLDIPLVSA PEATADNLFR ASTRVVGFSD VTPTLSVRKE DGKKEWVLDG YQVARNDGQG
KAAATFMHIS YNNFITEVNN LNKRMGDLRD INGEAGTWVR LLNGSGSADG GFTDHYTLLQ
MGADRKHELG SMDLFTGVMA TYTDTDASAG LYSGKTKSWG GGFYASGLFR SGAYFDLIAK
YIHNENKYDL NFAGAGKQNF RSHSLYAGAE VGYRYHLTDT TFVEPQAELV WGRLQGQTFN
WNDSGMDVSM RRNSVNPLVG RTGVVSGKTF SGKDWSLTAR AGLHYEFDLT DSADVHLKDA
AGEHQINGRK DGRMLYGVGL NARFGDNTRL GLEVERSAFG KYNTDDAINA NIRYSF
//
