ID A0A0J9VK48_FUSO4 Unreviewed; 1099 AA.
AC A0A0J9VK48;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 28-JAN-2026, entry version 40.
DE SubName: Full=Ubiquitin conjugation factor E4 B {ECO:0000313|EMBL:KNB11121.1};
GN ORFNames=FOXG_11140 {ECO:0000313|EMBL:KNB11121.1};
OS Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935
OS / NRRL 34936) (Fusarium vascular wilt of tomato).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=426428 {ECO:0000313|EMBL:KNB11121.1, ECO:0000313|Proteomes:UP000009097};
RN [1] {ECO:0000313|EMBL:KNB11121.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=4287 {ECO:0000313|EMBL:KNB11121.1};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Ma L.-J., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Young S., LaButti K., DeCaprio D.,
RA Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C.,
RA Larson L., White J., O'Leary S., Kodira C., Zeng Q., Yandava C.,
RA Alvarado L., Kistler C., Shim W.-B., Kang S., Woloshuk C.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KNB11121.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4287 {ECO:0000313|EMBL:KNB11121.1};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ubiquitin conjugation factor E4 family.
CC {ECO:0000256|ARBA:ARBA00007434}.
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DR EMBL; DS231709; KNB11121.1; -; Genomic_DNA.
DR RefSeq; XP_018249166.1; XM_018390656.1.
DR AlphaFoldDB; A0A0J9VK48; -.
DR GeneID; 28952565; -.
DR KEGG; fox:FOXG_11140; -.
DR VEuPathDB; FungiDB:FOXG_11140; -.
DR OrthoDB; 20295at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000009097; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0034450; F:ubiquitin-ubiquitin ligase activity; IEA:InterPro.
DR GO; GO:0036503; P:ERAD pathway; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:TreeGrafter.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR FunFam; 3.30.40.10:FF:000055; Ubiquitin conjugation factor e4 a; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR019474; Ub_conjug_fac_E4_core.
DR InterPro; IPR045132; UBE4.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13931:SF2; UBIQUITIN CONJUGATION FACTOR E4 B; 1.
DR PANTHER; PTHR13931; UBIQUITINATION FACTOR E4; 1.
DR Pfam; PF04564; U-box; 1.
DR Pfam; PF10408; Ufd2P_core; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51698; U_BOX; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Isomerase {ECO:0000256|ARBA:ARBA00023110};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Rotamase {ECO:0000256|ARBA:ARBA00023110};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 1011..1084
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 545..572
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..90
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1099 AA; 124801 MW; ECDC9F3A7367D9AD CRC64;
MDPNEQPSWA GGDAPDKEKM EQIRARRLAK LGTSTPVSAK SDENKAPDSE SSNPSRTSTP
KPQPQPQPAS AESRPKINVT SAAPPASSSP NPFDKLGVKA EPSSSTGTSS MNRKRLASEI
DDVVPADRPS PKPSTTQPES DESYADRTLS QIFRITVDPH NMVNSSGQRL TFLPNLNEEL
NESGEPLKLS VNTLDQALME AASSYPHDKP LMNYFLPCWK RAVKASLQFK GTEGPKFEVH
EEAKRLCMSG CLFALSMPDL YGRSPNPKHD TLMPYLLKGV QDENGLCFNF IQEAIKRFDD
DEAFPALFND AMVQISSKLG TISMDQDYKP YIQAMLTYTR FPPLIVNLAK HPTFTMAQSA
AGIEKHTLLG PFFRISPLQN EVIKSYFPGA RGLDKGRIAN SQDALRMVLR THQDDLFAIT
NAFIRAGQET RSRTLDWFAY IMNSNHKRRA LQVDPREVAS NGFMINVTTI LDRFCEPFMD
MDFSKVNKID DNYFRKQPRI NISDETKLNA DQSYADSFYA NKIPGETNFI SEAFFLTLAA
HHYGSEACNS QLKNLDRDIK YLEKRVKIME ADRIKFVNNP VQLQQYDKAV QRHVDALEKS
IAVKLSIEGV LLDERMQSTS LRFMRIVAVW LLRLVTRSEY KPGQESKEIQ LPLPAEKSDV
FSCLPEYTLQ NIVDNFKFIF RWLPKILPSA VGDEMIALCV TFLRSTEYIK NPYLKSSLVS
LLFSATWPLM HLKRGVLGDQ LVGSQFANDH LLKGLMKFYI ECESTGADSA FYDKFNIRYE
IFQVIKCVWV NDHYKRQLTR ESRVNKQFFV QFVNMLLNDA TYVLDEALTK FPKIRAIEKE
LEDPSIPQED RQKKEEEMQQ LANQATSFMQ LANETLEMMK LFTEAMSEAF TMPEIVSRLA
SMLNYNLETL AGKKAAAELS VSNRDKYHFR PIQIISDIVD IYLNLGNSPV FIDAVAADGR
SYKPEVLERV SRILISKHQK DPADVARWDK LRVKFVDAKT LLDQAELDLG DIPAEFEDPI
MGDLMKDPVL LPSKHIVDRS TIVQHLLSDP KDPFTRQAMT IDDAIPQTEL KERIEQWREE
RVQAAKDKLK SDVMDTTEG
//
