ID A0A0L0DTR7_THETB Unreviewed; 619 AA.
AC A0A0L0DTR7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 02-APR-2025, entry version 37.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=AMSG_01859 {ECO:0000313|EMBL:KNC55592.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC55592.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC55592.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC55592.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR EMBL; GL349439; KNC55592.1; -; Genomic_DNA.
DR RefSeq; XP_013761365.1; XM_013905911.1.
DR AlphaFoldDB; A0A0L0DTR7; -.
DR STRING; 461836.A0A0L0DTR7; -.
DR EnsemblProtists; KNC55592; KNC55592; AMSG_01859.
DR GeneID; 25561582; -.
DR eggNOG; KOG1815; Eukaryota.
DR OMA; PYAYYMD; -.
DR OrthoDB; 10009520at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd16773; RING-HC_RBR_TRIAD1; 1.
DR FunFam; 3.30.40.10:FF:000019; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:KNC55592.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 231..438
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 235..279
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 619 AA; 66898 MW; FCEF101ADD91DBE7 CRC64;
MAKVGHRTGS DEKLEAQVFN IDALFSDDSI SSSLDISDDD GSSSDQVNEA LSGVVVKPLE
LDPLYKRRNK GVKLSLQTVS WAPTAAGSGT ASDAPISTES EAIFVTDGVI FSPLLSGMSA
DSGPAFAFAD CGSDSDDSAH LDAEKGGVVM TPGSLAAEQQ AALDLVKSVL GLPELLARTL
LDHYGYDTSR MMEEFVDREA EVLAAIGWSE GENGAAASGT GDAGASDSAS ADAACAICFL
DDPAELAALS CGHPLCRDCW SSYLRIKITE NDVASIPCPA GECGVRADQA FVAKYVDAAV
FDKFQRFLLQ NFVTSNKNVV WCPAGGCENA VKVESALEAL CACGWRFCPS CNEECHVPVS
CAHMREWGKH LAEDNVNKAW ILNNTKDCPK CGVTIEKNMG CMHMSCGGHG TRVTGCGHEF
CWLCLGDWRT HSHCGRDETA GDRNSKRIGV VRQLHFTSRF EAHRDAHKLE LELRSRTVAN
IAAFRKAHPD SIVKLGYMLD AVEALLYCRK TLQFTYAYAF FLKPDSPEKN LFEYLQGELE
TSVETLSEAI DLPIDVEHRS KIKKLTRAAL RRLNHLLDGV EVGLTTDADD FKAVNVTTDE
AGASSGNRTT IRSLFSRRS
//
