ID   A0A0N0U5L4_9HYME        Unreviewed;       508 AA.
AC   A0A0N0U5L4;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   05-FEB-2025, entry version 26.
DE   RecName: Full=Gastric intrinsic factor {ECO:0008006|Google:ProtNLM};
GN   ORFNames=WN51_00499 {ECO:0000313|EMBL:KOX74544.1};
OS   Melipona quadrifasciata.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC   Anthophila; Apidae; Melipona.
OX   NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX74544.1, ECO:0000313|Proteomes:UP000053105};
RN   [1] {ECO:0000313|EMBL:KOX74544.1, ECO:0000313|Proteomes:UP000053105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0111107301 {ECO:0000313|EMBL:KOX74544.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KOX74544.1};
RA   Pan H., Kapheim K.;
RT   "The genome of Melipona quadrifasciata.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; KQ435784; KOX74544.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N0U5L4; -.
DR   STRING; 166423.A0A0N0U5L4; -.
DR   OrthoDB; 6343110at2759; -.
DR   Proteomes; UP000053105; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR   GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR   GO; GO:0015889; P:cobalamin transport; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.170.130.30; -; 1.
DR   InterPro; IPR002157; Cbl-bd_prot.
DR   InterPro; IPR051588; Cobalamin_Transport.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR10559:SF18; TRANSCOBALAMIN II; 1.
DR   PANTHER; PTHR10559; TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR; 1.
DR   Pfam; PF01122; Cobalamin_bind; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   4: Predicted;
KW   Cobalt {ECO:0000256|PIRSR:PIRSR602157-1};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR602157-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053105};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..508
FT                   /note="Gastric intrinsic factor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005859925"
FT   REGION          351..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         192
FT                   /ligand="cyanocob(III)alamin"
FT                   /ligand_id="ChEBI:CHEBI:17439"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602157-1"
FT   BINDING         236
FT                   /ligand="cyanocob(III)alamin"
FT                   /ligand_id="ChEBI:CHEBI:17439"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602157-1"
FT   DISULFID        165..203
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602157-2"
SQ   SEQUENCE   508 AA;  55470 MW;  C7BB4E2CF5B8E212 CRC64;
     MWGRASMAAV MVLLLTCCLC TLNVAYAKGS VADSTSSDTD AENILERATA WLWSQRNKDA
     GWGNDTHRVL LVLRLGNLSR EDNVAPAAPL ELQLSSKQME LEIVLLLWRH REVGFSPVRL
     ARYTLALNAM CTDPRQFHGH DLIGTLQHHE PPTDYEFALT TLAACNAQAH VRKRQIRRLL
     DIANAAQDHN VDTVAMVILA LKCIVQDHRH RNLHHFVRKP SIGLAQQQRL DGSFGDVRTT
     ALVMQALEEA ENEPADNWNR SAALAWLTSQ QRADGSFAGD VRATAEALLG VAPRGLASIR
     TLDCGQGLAE TLPPRFATNG NEPAAIPGNR NDSLSISVIS GTSVATNVTV GSSGTNGSNG
     HNGNIGNNGN NATNTLNASN TDGTIVTIAT PAMVNVSYTL WVGSNVNETY SLTMTAPKNE
     TFYEVMLLAA EMSPHFQFVA SEWPNGHYVH TIAGYKEEPM SYHYWLLYRL TTPPDPASPP
     GNQLVAPGGV DDLQISEGDH YLFWYKKL
//