ID A0A0N4WWC3_HAEPC Unreviewed; 677 AA.
AC A0A0N4WWC3;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 28-JAN-2026, entry version 37.
DE SubName: Full=Cadherin domain-containing protein {ECO:0000313|WBParaSite:HPLM_0001604701-mRNA-1};
GN ORFNames=HPLM_LOCUS16039 {ECO:0000313|EMBL:VDO58638.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|WBParaSite:HPLM_0001604701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0001604701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO58638.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO58638.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; UZAF01019243; VDO58638.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4WWC3; -.
DR STRING; 6290.A0A0N4WWC3; -.
DR WBParaSite; HPLM_0001604701-mRNA-1; HPLM_0001604701-mRNA-1; HPLM_0001604701.
DR OMA; REVQSHH; -.
DR OrthoDB; 26203at2759; -.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007411; P:axon guidance; IEA:UniProtKB-ARBA.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR FunFam; 2.60.40.60:FF:000104; cadherin-23 isoform X1; 1.
DR FunFam; 2.60.40.60:FF:000020; Dachsous cadherin-related 1b; 1.
DR FunFam; 2.60.40.60:FF:000080; FAT atypical cadherin 1; 1.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR055928; Fmi-1_DUF7505.
DR InterPro; IPR050174; Protocadherin/Cadherin-CA.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF263; CADHERIN-RELATED FAMILY MEMBER 1; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF24337; DUF7505; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..677
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5043124184"
FT DOMAIN 139..243
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 244..348
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 349..451
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 452..553
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 554..654
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 677 AA; 74775 MW; 8E11698C6879D1DC CRC64;
MHLNMALIFL FLPQFISASA ISAECHSCLP HPTNIYWISR SRPPCLHPGQ PIFDWPGKDC
PHSPGIHSDQ ISVDKSGLVF AKQRLCFYFA FEIIDYTYDC DGKRLDAKFR IGHPVFSKQR
RFKRWLRRRN PDPNTIHFQQ ESYVKELAES AAPGTLVVTV KAVHVADQPL YYSLAAPQDS
RSQNIFTLDT ISGEIRLAKS LDREILDKHV LKVTAYERLD PTVSSSVTVT VDVLDVQDNS
PIFERDSYFA DIREDAPIGT TVLSVFARDL DAGANGEILY SLAEGEGHDL LSINTKSGVI
QTAAPLDRET QSLIRLDVIA TDNGDPPRKS SALVEIGITD VNDNAPIFEQ EIYNISVMEN
ATLPATIARL KATDKDSGIN GKVHYSIVPT SQVPITVDYN TGEVVLRERL DARNSPFAVL
ARAKDGAQPA LSTTVSLLIY VVDINDHAPT FIASQKKVFL EENVAVGDEV GRVYAIDEDS
GDNGIIRYSL NGSSDFSIDP ESGIIRTTTS LDRERTAQYI LQVSATDRGD PPLSSSTEIM
VIVKDVNDNA PEFPKAEYNL SLSEETPRGS QIIVLKAEDK DAEQKIVYRI EHMDKDVVAL
IDLGEQGALL TLSGQLHSTD HLIGLEISAT DQGGLQGRCR VNIIVEDVNS PPYFTDQLFA
VRIPEDSPIG FHVITIK
//
