ID A0A0N5CQX5_THECL Unreviewed; 198 AA.
AC A0A0N5CQX5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 28-JAN-2026, entry version 30.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog {ECO:0000256|ARBA:ARBA00070663};
GN ORFNames=TCLT_LOCUS2626 {ECO:0000313|EMBL:VDM98689.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|WBParaSite:TCLT_0000262501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000262501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM98689.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function as a proteasomal ubiquitin receptor. May promote
CC the deubiquitinating activity associated with the 26S proteasome.
CC {ECO:0000256|ARBA:ARBA00054744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR EMBL; UYYF01000596; VDM98689.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N5CQX5; -.
DR STRING; 103827.A0A0N5CQX5; -.
DR WBParaSite; TCLT_0000262501-mRNA-1; TCLT_0000262501-mRNA-1; TCLT_0000262501.
DR OMA; RVNECTD; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT DOMAIN 29..148
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
SQ SEQUENCE 198 AA; 23070 MW; 8D0F7D6785CD21C2 CRC64;
MLAGFEYYKR ICPISDMSVM FANSRASQAN NGYLVEFKAG RSNLQPGSTV DRRKVVAEKT
KGLIFIKQSS DQLMHFCWKN RETGAIVDDL IIFPGDTEFL RVNECTDGRV YMLKFKSTDE
RRLFWMQDGK ADKDEENCKK VCSRLQRRQF FCMALIYKSY QYSRNFRCVT SIESIFSSSK
NIEPKLYLCV LMKLLLSL
//
