ID A0A0N5D5F0_THECL Unreviewed; 743 AA.
AC A0A0N5D5F0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 02-APR-2025, entry version 39.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=TCLT_LOCUS8219 {ECO:0000313|EMBL:VDN05755.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|WBParaSite:TCLT_0000823001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000823001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN05755.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR EMBL; UYYF01004601; VDN05755.1; -; Genomic_DNA.
DR STRING; 103827.A0A0N5D5F0; -.
DR WBParaSite; TCLT_0000823001-mRNA-1; TCLT_0000823001-mRNA-1; TCLT_0000823001.
DR OMA; CPLCFIR; -.
DR OrthoDB; 1431934at2759; -.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20338; BRcat_RBR_RNF19; 1.
DR CDD; cd16629; RING-HC_RBR_RNF19; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.20.25.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 1.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 337..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 111..336
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 115..163
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 592..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 81847 MW; 5E4CD56EEDC27C81 CRC64;
MNGTDNDQPL TNATAGSVPH LDSCFLRHSS ANVNCQSQCI SSKGDENCLL PFKRLEIFGT
VSRSGIDFEH AMQDINDQCS RSGTSGNSDN NSTQVVRQLV QHNDSFVSFR KCRECPLCFI
RQPLMNFPRI SCCNHRSCKS CLVQYLQVEI MESRVQLTCP ECSELLHPTD IYSLMEHCPE
LIEKYETFAL RRVLMMDPDA RWCPAPDCTY AVIATSCAAC PELRCERPGC GALFCYHCKG
PWHASQTCDE ARKARGEIYR RAAPQLMNSQ DNILKRGDIK ACPRCRTYIV KMNDGSCNHM
VCAMCNVQFC WLPTGCTFWG KKPWTRKKKL LCQIGTLIGA PVGIALIAGL AIPGIIFGVP
VFVGRKVNQR FAHLTKIRRR CLTVGSVVGS LVVSPVLAVM AVGVGVPIML AYVYGVVPLS
LCRNGGCGVS SSSSKLEQDN LDDYEIWHEV NNRSREKSPL LNDIERQDGT SVVTRMSLNS
GLSGVQAVHN RLQVQAELCR RRPSIESGIT SLGEKCNYEE ASTKAMAGSQ YNDDKSVQTL
CSGQEAISYC EEVASIVALA GSVVDAKSLT DSASGRVFVT QMYCRERDLS PSSQHAISCD
DPTKSGDERS CENQQQHRQE VAALMREDTV SYEDTSKRRG RAVSSVSAAN VGVTLLQVSH
GSCTNSRYGI VAANVASNLF HAVWSTHSSD SSNAKADRFH IRALFDTMKR IVSDDVAAEP
SRDYHRPVLR RSAQEDISPN SNG
//
