ID A0A0P6WA00_9HYPH Unreviewed; 684 AA.
AC A0A0P6WA00;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 18-JUN-2025, entry version 37.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00044770};
DE EC=2.4.99.28 {ECO:0000256|ARBA:ARBA00044770};
GN ORFNames=ABB55_23225 {ECO:0000313|EMBL:KPL56083.1};
OS Prosthecomicrobium hirschii.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Hyphomicrobiales; Kaistiaceae; Prosthecomicrobium.
OX NCBI_TaxID=665126 {ECO:0000313|EMBL:KPL56083.1, ECO:0000313|Proteomes:UP000048984};
RN [1] {ECO:0000313|EMBL:KPL56083.1, ECO:0000313|Proteomes:UP000048984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16 {ECO:0000313|EMBL:KPL56083.1,
RC ECO:0000313|Proteomes:UP000048984};
RA Jackson K.R., Lunt B.L., Fisher J.N.B., Gardner A.V., Bailey M.E.,
RA Deus L.M., Earl A.S., Gibby P.D., Hartmann K.A., Liu J.E., Manci A.M.,
RA Nielsen D.A., Solomon M.B., Breakwell D.P., Burnett S.H., Grose J.H.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KPL56083.1, ECO:0000313|Proteomes:UP000048984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16 {ECO:0000313|EMBL:KPL56083.1,
RC ECO:0000313|Proteomes:UP000048984};
RA Daniel J., Givan S.A., Brun Y.V., Brown P.J.;
RT "Draft Genome Sequence of Prosthecomicrobium hirschii ATCC 27832.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.99.28;
CC Evidence={ECO:0000256|ARBA:ARBA00049902};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the transpeptidase
CC family. {ECO:0000256|ARBA:ARBA00007090}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 51 family. {ECO:0000256|ARBA:ARBA00007739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPL56083.1}.
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DR EMBL; LJYW01000001; KPL56083.1; -; Genomic_DNA.
DR RefSeq; WP_054362250.1; NZ_LJYW01000001.1.
DR AlphaFoldDB; A0A0P6WA00; -.
DR STRING; 665126.ABB55_23225; -.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000048984; Unassembled WGS sequence.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:TreeGrafter.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR050396; Glycosyltr_51/Transpeptidase.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000048984};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 51..217
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 295..527
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 592..681
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 684 AA; 73416 MW; 44FF439769EE98EE CRC64;
MVGIAAVGGA LSGARAFMDG LGPLDLAAAE HRSTIVVDRD GRLLRPFVTV DGRWRLPLDP
SEVDTDYLKL LYAYEDDRFR QHGGVDWRAM GRAVVQFATS GRVVSGASTL TMQVARLIEP
RDERNVAAKL RQIARAAELE RRFTKDQILA IYLRLAPEGG NIEGIRAASY AYFGKEPRRL
SHAEAALLVA LPQSPELRRP DRRPDLARRA RDRVLDRALA KGVLNAAEVA RAKAEAVPTG
RQPFPVHAPH LSEQLVAERP EERVHRTTVD ARLQTSLEAL AGARVQGLGP KVSVAILVVD
NATGEVHAHV GGADYFATER AGSVDLARAF RSPGSALKPF IYALAFENGI AHPETVLEDR
PARYGAWAPE NFDQSFHGTV TARRALQNSL NVPAVELLGA VGPARLIARL KAAGAEIEMP
REAAPGLAVG LGGLGIRLVD AARLYTAFAR GGETISLTWR RDEPGSETDR HRFVDAVSAW
YVADILKGAP PPTNGAQGLI AFKTGTSYGY RDAWAVGFDK RWTIAVWVGR PDGAPVVGLV
GRLVAAPILF DAYARIGTPP ETVPQPRDTL VATSTTLPPP LRHLRRDIPK TVSAATEAAL
AISFPPDGAR IDLGLARFGP EVAGPLALKA LGGVPPLVWM VNGVPVTTAG SRRTAFWQPD
GAGYSQVSVI DARGSTASVR VRLD
//
