ID A0A0P7W8L2_SCLFO Unreviewed; 387 AA.
AC A0A0P7W8L2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 28-JAN-2026, entry version 48.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|EMBL:KPP57220.1, ECO:0000313|Ensembl:ENSSFOP00015015366.1};
GN Name=socs4 {ECO:0000313|Ensembl:ENSSFOP00015015366.1};
GN ORFNames=Z043_125079 {ECO:0000313|EMBL:KPP57220.1};
OS Scleropages formosus (Asian bonytongue) (Osteoglossum formosum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP57220.1, ECO:0000313|Proteomes:UP000034805};
RN [1] {ECO:0000313|EMBL:KPP57220.1, ECO:0000313|Proteomes:UP000034805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP57220.1};
RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT "The genome of the Asian arowana (Scleropages formosus).";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSFOP00015015366.1, ECO:0000313|Proteomes:UP000694397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Wellcome Sanger Institute Data Sharing;
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSSFOP00015015366.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; JARO02017177; KPP57220.1; -; Genomic_DNA.
DR RefSeq; XP_018583027.1; XM_018727511.2.
DR AlphaFoldDB; A0A0P7W8L2; -.
DR STRING; 113540.ENSSFOP00015015366; -.
DR Ensembl; ENSSFOT00015015548.2; ENSSFOP00015015366.1; ENSSFOG00015009925.2.
DR GeneID; 108919519; -.
DR KEGG; sfm:108919519; -.
DR CTD; 122809; -.
DR GeneTree; ENSGT00940000166202; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000034805; Unassembled WGS sequence.
DR Proteomes; UP000694397; Chromosome 15.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694397};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 241..336
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 331..380
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 43503 MW; 8082F15C2D12299B CRC64;
MDSGEAGVSE KKKKSDARPK CVRSWSADSY VWSSKKGANR SKTGVRHAEG DRAEDSGARS
ASCPRRRRER KCSCTSLSEA NSEPPCQKAL SRRSLRQKFQ EAVGQCFPIR THHHCHHQSG
TSHPFSVLLW SKRKIHVSDL SQEKCHFSTT SELVHCWHLI KKQSSPNGNT ARVESSHRAK
GFSSSSSTSS PPFASWEEIS CRGGQSPGNW DSSFPHEAED PCSHADYVLV PDLLQINNSP
CYWGVLDRFE AEELLEGQPE GTFLLRDSAQ DEFLFSVSFR RYSRSLHARI EQNGKRFSFD
GSDPCVYRDP SVTGLLKHYS NPATCLFFEP LLSRPLPRNF PFSLQHLSRA VICSCTTYQG
IEALPLPPAL RDYLRQYHFK CNGACAV
//
