ID A0A0R1SB66_9LACO Unreviewed; 635 AA.
AC A0A0R1SB66;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 28-JAN-2026, entry version 41.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=FC27_GL000676 {ECO:0000313|EMBL:KRL66305.1};
OS Companilactobacillus versmoldensis DSM 14857 = KCTC 3814.
OC Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Companilactobacillus.
OX NCBI_TaxID=1423815 {ECO:0000313|EMBL:KRL66305.1, ECO:0000313|Proteomes:UP000051647};
RN [1] {ECO:0000313|EMBL:KRL66305.1, ECO:0000313|Proteomes:UP000051647}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14857 {ECO:0000313|EMBL:KRL66305.1,
RC ECO:0000313|Proteomes:UP000051647};
RX PubMed=26415554; DOI=10.1038/ncomms9322;
RA Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA Zhang H., O'Toole P.W.;
RT "Expanding the biotechnology potential of lactobacilli through comparative
RT genomics of 213 strains and associated genera.";
RL Genome Announc. 6:8322-8322(2015).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRL66305.1}.
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DR EMBL; AZFA01000016; KRL66305.1; -; Genomic_DNA.
DR RefSeq; WP_010624954.1; NZ_AZFA01000016.1.
DR AlphaFoldDB; A0A0R1SB66; -.
DR STRING; 1423815.FC27_GL000676; -.
DR PATRIC; fig|1423815.3.peg.685; -.
DR eggNOG; COG3276; Bacteria.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000051647; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:KRL66305.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000051647}.
FT DOMAIN 6..179
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 635 AA; 70965 MW; CCF9AC9ED13333B6 CRC64;
METVGQDQII IATAGHVDHG KTTLIRALTG IDTDTTAAEK KRGLTINLGF AFFDLPNHEQ
VGIVDVPGHQ RFLKNMIAGL SGIDLVLLVV DAGEGIMPQT KEHVEIMSLL GIDNYIVVLS
KIDTVDDEMK DLVTEDVKDF MKVHKIEAPI MPVDAVSGTG MDELIKVMDQ KVESIKKPKF
NGVPRINVDR SFSIKGFGTI ITGTLLEGSV ENGMTLEVFP SGKQAKIRNI QVHDEDVDKA
MPGTRTAINL ANLKTEEVRR GDVLTLPGNV KPTSMLDISF KLLPDKSAHL VNLWSRVRVY
LGAQEVIARV VPLGEEHVSA NGDNYLQLRL EEPVAVKKGD HYILRSYSPM TLIGGGTILD
PNPKKHRRYN EDVLEQLSIQ ASGNQEQIVL EFLMNQAELG VTVDGIADYL NISVDDTKEI
VNDLVEAKTA VKFGKIVINQ ERLASFEKEV IAALDAYHKK NRLQKGMNKE ELLSSFKDQV
DGKTMEKILE NMVTQKKVRI SGYIVADADF KVKFNKYQEK AYQEIIADLQ KKPLMPPSDT
DLTGDDKNKK EVLQSLEGQQ VVRLGEKNVM LKSVFDDVTK KVIKYLKENE TMTIAEFRDL
SGASRKYGMM ILEYMDKQGV TRRKENMRVL TRRES
//
