ID   A0A0V0RU11_9BILA        Unreviewed;       714 AA.
AC   A0A0V0RU11;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   18-JUN-2025, entry version 26.
DE   RecName: Full=E3 UFM1-protein ligase 1 homolog {ECO:0000256|ARBA:ARBA00014160};
DE   AltName: Full=E3 UFM1-protein transferase 1 homolog {ECO:0000256|ARBA:ARBA00030452};
GN   Name=UFL1 {ECO:0000313|EMBL:KRX17969.1};
GN   ORFNames=T07_8394 {ECO:0000313|EMBL:KRX17969.1};
OS   Trichinella nelsoni.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX17969.1, ECO:0000313|Proteomes:UP000054630};
RN   [1] {ECO:0000313|EMBL:KRX17969.1, ECO:0000313|Proteomes:UP000054630}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS37 {ECO:0000313|EMBL:KRX17969.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC       proteins. {ECO:0000256|ARBA:ARBA00003950}.
CC   -!- SIMILARITY: Belongs to the UFL1 family.
CC       {ECO:0000256|ARBA:ARBA00010789}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX17969.1}.
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DR   EMBL; JYDL01000079; KRX17969.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0RU11; -.
DR   OrthoDB; 10258297at2759; -.
DR   Proteomes; UP000054630; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:TreeGrafter.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; IEA:TreeGrafter.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:TreeGrafter.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:TreeGrafter.
DR   InterPro; IPR018611; Ufl1.
DR   InterPro; IPR056761; Ufl1-like_C.
DR   InterPro; IPR056580; Ufl1_dom.
DR   InterPro; IPR056579; Ufl1_N.
DR   PANTHER; PTHR31057; E3 UFM1-PROTEIN LIGASE 1; 1.
DR   PANTHER; PTHR31057:SF0; E3 UFM1-PROTEIN LIGASE 1; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
DR   Pfam; PF23659; UFL1; 1.
DR   Pfam; PF25041; UFL1_C; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000313|EMBL:KRX17969.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          6..284
FT                   /note="E3 UFM1-protein ligase 1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09743"
FT   DOMAIN          506..597
FT                   /note="E3 UFM1-protein ligase 1-like"
FT                   /evidence="ECO:0000259|Pfam:PF23659"
FT   DOMAIN          611..710
FT                   /note="E3 UFM1-protein ligase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF25041"
FT   REGION          402..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..429
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   714 AA;  80219 MW;  90D5AEF1610C01E4 CRC64;
     MASWDEIKSL AADLRRVQLG ESSKKLSQRN CIELITKLVE NGMLEVITSV NRKDYITPEY
     LLTQIKNEII ANEGRVSLAS LQQVLGVDFN IIEKQVNQLV ATDESLSLCL GQIISKDYMN
     KVCIEIDKLL AKQGKLSVGD LAKKYDFPTA FLAEEVYHQI GKAIHGFVDS ADSNIILTKA
     FVERQTAILR GVLSGCTRVI SVKKLVTEFN VEPSLFFSCF DELRSRGYIR GVLYGGNQVE
     RAVFMPEICV EKLKSHVLDF YRKNGYIELS YVKKFGVSDV SQFLTRLLIS ENGCEPYKNL
     KESLLSEKLW LEFESVAKEM MAQNLWLDVS TIAPEVLSDA DICCLADMLE KGNKKWNRLE
     DLYFFDESLA SSCLHLFDLL ILEKADKDAP LYKKSLQQQQ QHQKGACQSQ EKARGKKKAA
     AHVKGKKKKV GNDNDEDETS RSALSTFMTA EQIVTVLKDS VTLENCPDCI LEELSEMLVS
     PLNAKYRARL DAVFLIAYDS HRKTRTDLSE KMNRLYSTIT LSDLSLSVFD EKLAQQLRLH
     LLRGACTDLA NLALGDYADI PNPLEITKKV RDSAIQEMVS PAKEYFEALF ASLGEKVASS
     GDLTEMVNNR CNYLAEELKA CSEPATALLL SCLLLFTLTT NQLLLASGKF VPQLIAFLLD
     QLASDMKELL LQAQEAVVSF LKGEQNEESK NAAMEMVHLL REKILTDVEE KVKL
//