ID A0A0V0S305_9BILA Unreviewed; 450 AA.
AC A0A0V0S305;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 18-JUN-2025, entry version 28.
DE RecName: Full=Histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184, ECO:0000256|RuleBase:RU361211};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184, ECO:0000256|RuleBase:RU361211};
DE Flags: Fragment;
GN Name=KAT8 {ECO:0000313|EMBL:KRX21080.1};
GN ORFNames=T07_4130 {ECO:0000313|EMBL:KRX21080.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX21080.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX21080.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX21080.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein]
CC + CoA + H(+); Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-
CC COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000256|RuleBase:RU361211};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU361211}.
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107, ECO:0000256|RuleBase:RU361211}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX21080.1}.
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DR EMBL; JYDL01000042; KRX21079.1; -; Genomic_DNA.
DR EMBL; JYDL01000042; KRX21080.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0S305; -.
DR STRING; 6336.A0A0V0S305; -.
DR OrthoDB; 787137at2759; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0072487; C:MSL complex; IEA:TreeGrafter.
DR GO; GO:0044545; C:NSL complex; IEA:TreeGrafter.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046972; F:histone H4K16 acetyltransferase activity; IEA:TreeGrafter.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR050603; MYST_HAT.
DR InterPro; IPR025995; Tudor-knot.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR040706; Zf-MYST.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF82; HISTONE ACETYLTRANSFERASE KAT8; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR Pfam; PF17772; zf-MYST; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Nucleus {ECO:0000256|RuleBase:RU361211};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KRX21080.1}.
FT DOMAIN 167..439
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT ACT_SITE 341
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX21080.1"
SQ SEQUENCE 450 AA; 52489 MW; 0B412209F65F9B04 CRC64;
LFLFPMTADD QCDVDEKMET SDSNSDDAAE HNLKALEDEM IIDMPSEDVE PLLGEFYMVR
DSQNVWRRAE VIQKRTNLLK NGEVEYFVHF DGDERRMDKW ISRNDIDVSV CKTNECQHSP
VDSALESNLN VVQTRQQKRL NAEVPKADDG HLDPHTAQLE KQREINTRIK YIAEIQLGNF
RISTWYFSCY PDEFLRPLLF ICDRCMKYMK YVKTLKAHMK VCYSRPLPGR TVYRKNNLMV
IEVDGNESKL YCQFASLLGK LFIDHKTVCY LIGEFMFYVL YEVVDGEQHV AGFFSKEKRS
TENNLACIVI FPPYQRKGYG SFLIQMSYAM SKREGIIGGP ERPLSDIGRR AYRTYWAWEI
VKLFAKNIGV TMQISEIVEK TGIERHDVQD TLLEMNITYF YNGRRVVPVT MELVDRCINS
PGYRVPLTIF DENCLKWSPL VNATRKRNSI
//
